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All Journal Jurnal Ilmiah Farmasi Farmasyifa Journal SAGO Gizi dan Kesehatan Kieraha Medical Journal
Muhammad Fakhrur Rajih
Universitas Khairun
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Review artikel : Aktivitas farmakologi pala (Myristica fragrans Houtt.) Rajih, Muhamamad Fakhrur
Kieraha Medical Journal Vol 3, No 2 (2021): KIERAHA MEDICAL JOURNAL
Publisher : Fakultas Kedokteran, Universitas Khairun

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (21.741 KB) | DOI: 10.33387/kmj.v3i2.3797

Abstract

Myristica fragrans Houtt merupakan salah satu spesies tanaman yang berasal dari pulau banda. Ekstrak biji pala dan minyak atsiri penting dalam pengembangan obat dengan berbagai aktivitas farmakologi di Indonesia, India dan negara-negara tropis. Artikel review ini dibuat menggunakan penulusuran pustaka menggunakan data sekunder yang diperoleh dari data base literatur ilmiah PubMed dan Google Cendekia. Myristica fragrans Houtt baru-baru ini telah menunjukkan antikanker, analgesik, afrodisiak, antiinflamasi, antidiabetes, antibakteri, antialzheimer, antidepresan, antiplatelet, antioksidan, pestisida dan aktivitas antijamur. Aritikel ini menyajikan informasi tentang aspek farmakologi Myristica fragrans Houtt.
AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN JAMBU AIR [Eugenia aqueum (Burm. F) Alston] DENGAN MIKRODILUSI AGAR Lanny Mulqie; Suwendar Suwendar; Muhammad Fakhrur Rajih; Dieni Mardliyani; Imas Yumniati; Widiasari Widiasari; Zakiyyah Nurrosyidah
Jurnal Ilmiah Farmasi Farmasyifa Vol 5, No 1 (2022)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jiff.v5i1.7849

Abstract

Sumber daya alam yang dimiliki Indonesia cukup berlimpah. Tanaman merupakan sumber daya alam yang banyak dimanfaatkan sebagai obat. Salah satu tanaman obat yang dapat digunakan sebagai obat tradisional adalah jambu air. Tujuan penelitian ini yaitu untuk melihat aktivitas antibakteri ekstrak etanol daun jambu air terhadap S. aureus, dan E.coli dan penetapan nilai konsentrasi hambat minimum (KHM), serta pengujian konsentrasi bunuh minimum (KBM). Ekstraksi dilakukan secara maserasi dengan etanol 96%. Penetapan KHM dilakukan dengan metode mikrodilusi agar. Pengujian KBM dilakukan dengan menggoreskan sejumlah 5 µL alikuot dari sumur pelat mikro yang menunjukkan kejernihan diatas media MHA. Nilai KHM dan KBM ekstrak etanol daun jambu air terhadap S. aureus, dan E.coli yaitu 20.000 μg/mL dan 40.000 μg/mL.
AKTIVITAS ANTIJAMUR EKSTRAK ETANOL PALA (Myristica fragrans HOUTT.) TERHADAP Malassezia furfur DAN Tricophyton mentagrophytes Muhamamad Fakhrur Rajih; Nur Asma Somadayo
Jurnal Ilmiah Farmasi Farmasyifa Vol 6, No 1 (2023)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jiff.v6i1.10063

Abstract

Indonesia is a tropical country that has fair temperature and humidity supporting the growth of pathogenic fungi. Pathogenic fungi commonly encountered infecting humans in Indonesia are the species Malassezia furfur and Trichophyton mentagrophytes. Nutmeg (Myristica fragrans Houtt.) is one of the Indonesian plants known to have potential antifungal activity. The purpose of this study was to examine the antifungal activity of the nutmeg ethanol extract against Malassezia furfur and Trichophyton mentagrophytes, determining the Minimum Inhibitory Concentration (MIC) and Minimum Killing Concentration (MKC) as well as testing the comparative value of nutmeg ethanol extract with ketoconazole. The research method used in testing the antifungal activity and the comparative value of the ethanol extract of nutmeg was the diffusion method for the paper disc technique and the microdilution method for testing the determination of MIC and MKC values. The results of this study show that the nutmeg ethanol extract had antifungal activity against Malassezia furfur and Trichophyton mentagrophytes.The MIC and MKC values of the nutmeg ethanol extract were the same for Malassezia furfur and Trichophyton mentagrophytes, namely the MIC value of the ethanol extract was 2,5%. Meanwhile, MKC value for ethanol extract was 5%, .The comparative values of ketoconazole antifungal activity with ethanol extract of the nutmeg against Malassezia furfur were 1:34, whereas against Trichophyton mentagrophytes were 1:12
Efektivitas ekstrak daging buah pala (Myristica fragrans Houtt) terhadap histopatologi hati pada tikus hiperglikemia Amran Nur; Safitri Hasda Nur; Nur Asma S. Somadayo; Muhammad Fakhrur Rajih
Jurnal SAGO Gizi dan Kesehatan Vol 5, No 3B (2024): Nopember
Publisher : Poltekkes Kemenkes Aceh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30867/gikes.v5i3B.1927

Abstract

Background: Hyperglycemia can occur due to insulin resistance, which affects the metabolism of lipids, carbohydrates, proteins, and fatty acids in the liver, which will ultimately cause cirrhosis, steatohepatitis, liver cancer, and other liver disorders.Objectives: To determine the effect of administering nutmeg pulp extract (Myristica fragrans H.) on the histopathological picture of the liver of hyperglycemic mice induced by high carbohydrate feed.Methods: The research was carried out using an experimental method using 25 white rats (Rattus norvegicus) of the Wistar strain, which were divided into five groups, K- (NaCMC 1%), K+ (Metformin), P1-P3 respectively Nutmeg extract 100mg/kgBW, 200mg/kgBB, 300mg/kgBB). The entire group was given high carbohydrate feed for 30 days, then extract and Metformin for seven days. On the 36th day, the liver was removed, and histopathology preparations were made. The main research outcome parameters include initial blood sugar levels before induction (T0), final day blood sugar levels (T30), blood sugar levels on days 1, 3, 5, and 7 after sample administration, liver weight, and liver severity score. The data obtained were analyzed using Oneway-Anova with a significance of 0.05, and LSD as a further testResults: The K+, P1, and P3 groups showed a significant reduction in sugar compared to the control group (p<0.05), but all groups did not show an improvement in liver histopathology with damage scores in the mild to severe damage category.Conclusion: Nutmeg pulp extract at doses of 100mg/kgBB, 200mg/kgBB, and 300mg/kgBB showed effectiveness in reducing blood sugar in hyperglycemic white mice but could not show optimal improvement in liver cell damage.Keywords:Diabetes mellitus, Histopatology, Liver, Myristica fragrans, Nutmeg Flesh.
Co-Authors Amran Nur Dieni Mardliyani Imas Yumniati Lanny Mulqie Nur Asma S. Somadayo Nur Asma Somadayo Safitri Hasda Nur Suwendar Suwendar Widiasari Widiasari Zakiyyah Nurrosyidah