Garuda - Garba Rujukan Digital

Pengaruh Ekstrak Etanol Daun Sirsak terhadap Histologi Tumor Payudara Tikus Putih Betina Sprague Dawley Teguh Rinjaya; Muhammad In’am Ilmiawan; Mardhia Mardhia
Cermin Dunia Kedokteran Vol. 49 No. 9 (2022): Neurologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v49i9.292

Kanker payudara merupakan kasus kanker tertinggi pada wanita di seluruh dunia dan penyebab kematian terbesar akibat kanker. Salah satu tanaman yang diketahui dapat bersifat sebagai anti-kanker adalah daun sirsak. Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak etanol daun sirsak terhadap histologi sel tumor payudara pada tikus betina galur Sprague Dawley. Penelitian eksperimental dengan desain post-test only control group. Proses induksi tumor payudara dengan pemberian 7,12 dimetilbenz(α)antracene (DMBA) dan estrogen. Total subjek penelitian adalah 30 ekor tikus betina galur Sprague Dawley yang dibagi menjadi 6 kelompok, yaitu normal, kontrol negatif (DMSO 5%), kontrol positif (tamoxifen per oral 50 mg/kgBB/hari), perlakuan I (ekstrak daun sirsak per oral 75 mg/kg/hari), perlakuan II (ekstrak daun sirsak per oral 150 mg/kgBB/hari), dan perlakuan III (ekstrak daun sirsak per oral 300 mg/kgBB/hari); perlakuan diberikan selama 9 hari. Uji statistik Fischer exact test menunjukkan tidak terdapat perbedaan gambaran jaringan histologi secara bermakna antar kelompok perlakuan. Ekstrak etanol daun sirsak dosis 300 mg/kgBB/hari tidak memengaruhi histologi tumor payudara. Breast cancer is the most frequent cancer and cause of cancer death in women worldwide. Soursop leaf has been known to have anti-cancer properties. This study aimed to determine the effect of soursop leaf ethanol extract on the histology of breast tumor in female Sprague Dawley rats. This is an experimental study with a post-test only control group design. Breast tumor was induced by 7,12 dimethylbenz(α)anthracene (DMBA) and estrogen injection. The total subjects were 30 female rats Sprague Dawley divided into 6 groups: normal, negative control (DMSO 5%), positive control (tamoxifen oral 50 mg/kgBW/day), treatment I (soursop leaf extract oral 75 mg/kgBW/day, treatment II (soursop leaf extract oral 150 mg/kgBW/day), and treatment III (soursop leaf extract oral 300 mg/kgBW/day). Each treatment was for 9 days. Analysis with Fischer exact test resulted in no significant difference in histological characteritics among the treatment groups. Ethanol extract of soursop leaves at a dose of 300 mg/kgBW/day did not affect the histology of breast tumor.

Hubungan Usia Onset dengan Fungsi Kognitif Pasien Epilepsi di RSUD dr. Soedarso Kota Pontianak, Indonesia Ariesta Nurtria Khansa; Dyan Roshinta Laksmi Dewi; Muhammad In’am Ilmiawan
Cermin Dunia Kedokteran Vol. 49 No. 11 (2022): Neurologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v49i11.313

Latar Belakang: Epilepsi adalah gangguan susunan saraf pusat yang ditandai bangkitan spontan berulang. Salah satu faktor yang dapat memengaruhi fungsi kognitif pasien epilepsi adalah usia saat onset. Tujuan: Mengetahui hubungan antara usia saat onset dan fungsi kognitif pasien epilepsi di Poliklinik Saraf RSUD dr.Soedarso Pontianak. Metode: Penelitian analitik observasional cross-sectional. Subjek penelitian berjumlah 36 orang. Variabel bebas penelitian adalah usia pasien saat didiagnosis epilepsi, sedangkan variabel terikat adalah fungsi kognitif pasien epilepsi. Hasil: Distribusi pasien epilepsi terbanyak pada golongan usia dewasa muda (usia 18-25 tahun; 30,5%), laki-laki (55,6%), tingkat pendidikan terakhir SMA (44,4%), tidak bekerja (50%), dan belum menikah (52,8%). Kebanyakan onset epilepsi pada usia 19-60 tahun (58,3%), dengan frekuensi bangkitan tidak sering (75%). Sebagian besar pasien teratur minum obat anti-epilepsi (77,8%) dan telah didiagnosis epilepsi selama 15-30 tahun (44,4%). Sebanyak 9 (25%) pasien epilepsi mengalami penurunan fungsi kognitif yang nyata dan 17 orang (47,2%) kemungkinan (probable) mengalami penurunan fungsi kognitif. Uji korelasi Kendal tau menghasilkan adanya hubungan antara usia saat onset dan fungsi kognitif (p<0,004). Simpulan: Terdapat hubungan antara usia onset dan fungsi kognitif pada pasien epilepsi di Poliklinik Saraf RSUD dr. Soedarso kota Pontianak. Background: Epilepsy is a central nervous system disorder characterized by spontaneous recurrent seizures. Age at onset is one of the factors that may influence cognitive function in epilepsy patients. Aim: To search the relationship between the age at onset and cognitive function among epilepsy patients in the Neurology Polyclinic, dr. Soedarso Regional Hospital, Pontianak City, Indonesia. Methods: An analytic observational study with a cross-sectional method. The total subjects were 36 patients. The independent variable was the age of patients at diagnosis, and the dependent variable was cognitive function. Results: Most epilepsy patients were in young adult age (18-25 years; 30.5%), male (55.6%), with high school as the highest level of education (44.4%), unemployed (50%), and not married (52.8%). The onset of epilepsy is mostly at 19 to 60 years old (58.3%), with infrequent seizure frequency (75%). Most patients are regularly taking anti-epileptic drugs (77.8%), and have been diagnosed for 15-30 years (44.4%). A total of 9 (25%) patients experienced a marked decline in cognitive function, and 17 people (47.2%) experienced a probable decline in cognitive function. Kendal tau correlation test resulted in a relationship between the age at onset and cognitive function (p<0.004). Conclusion: There is a relation between the age at onset and cognitive function among epilepsy patients in dr. Soedarso Regional Hospital of Pontianak City.

Pengaruh Ekstrak Etanol Daun Sirsak terhadap Histologi Tumor Payudara Tikus Putih Betina Sprague Dawley Teguh Rinjaya; Muhammad In’am Ilmiawan; Mardhia Mardhia
Cermin Dunia Kedokteran Vol 49 No 9 (2022): Neurologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v49i9.292

Kanker payudara merupakan kasus kanker tertinggi pada wanita di seluruh dunia dan penyebab kematian terbesar akibat kanker. Salah satu tanaman yang diketahui dapat bersifat sebagai anti-kanker adalah daun sirsak. Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak etanol daun sirsak terhadap histologi sel tumor payudara pada tikus betina galur Sprague Dawley. Penelitian eksperimental dengan desain post-test only control group. Proses induksi tumor payudara dengan pemberian 7,12 dimetilbenz(α)antracene (DMBA) dan estrogen. Total subjek penelitian adalah 30 ekor tikus betina galur Sprague Dawley yang dibagi menjadi 6 kelompok, yaitu normal, kontrol negatif (DMSO 5%), kontrol positif (tamoxifen per oral 50 mg/kgBB/hari), perlakuan I (ekstrak daun sirsak per oral 75 mg/kg/hari), perlakuan II (ekstrak daun sirsak per oral 150 mg/kgBB/hari), dan perlakuan III (ekstrak daun sirsak per oral 300 mg/kgBB/hari); perlakuan diberikan selama 9 hari. Uji statistik Fischer exact test menunjukkan tidak terdapat perbedaan gambaran jaringan histologi secara bermakna antar kelompok perlakuan. Ekstrak etanol daun sirsak dosis 300 mg/kgBB/hari tidak memengaruhi histologi tumor payudara. Breast cancer is the most frequent cancer and cause of cancer death in women worldwide. Soursop leaf has been known to have anti-cancer properties. This study aimed to determine the effect of soursop leaf ethanol extract on the histology of breast tumor in female Sprague Dawley rats. This is an experimental study with a post-test only control group design. Breast tumor was induced by 7,12 dimethylbenz(α)anthracene (DMBA) and estrogen injection. The total subjects were 30 female rats Sprague Dawley divided into 6 groups: normal, negative control (DMSO 5%), positive control (tamoxifen oral 50 mg/kgBW/day), treatment I (soursop leaf extract oral 75 mg/kgBW/day, treatment II (soursop leaf extract oral 150 mg/kgBW/day), and treatment III (soursop leaf extract oral 300 mg/kgBW/day). Each treatment was for 9 days. Analysis with Fischer exact test resulted in no significant difference in histological characteritics among the treatment groups. Ethanol extract of soursop leaves at a dose of 300 mg/kgBW/day did not affect the histology of breast tumor.

Hubungan Usia Onset dengan Fungsi Kognitif Pasien Epilepsi di RSUD dr. Soedarso Kota Pontianak, Indonesia Ariesta Nurtria Khansa; Dyan Roshinta Laksmi Dewi; Muhammad In’am Ilmiawan
Cermin Dunia Kedokteran Vol 49 No 11 (2022): Neurologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v49i11.313

Latar Belakang: Epilepsi adalah gangguan susunan saraf pusat yang ditandai bangkitan spontan berulang. Salah satu faktor yang dapat memengaruhi fungsi kognitif pasien epilepsi adalah usia saat onset. Tujuan: Mengetahui hubungan antara usia saat onset dan fungsi kognitif pasien epilepsi di Poliklinik Saraf RSUD dr.Soedarso Pontianak. Metode: Penelitian analitik observasional cross-sectional. Subjek penelitian berjumlah 36 orang. Variabel bebas penelitian adalah usia pasien saat didiagnosis epilepsi, sedangkan variabel terikat adalah fungsi kognitif pasien epilepsi. Hasil: Distribusi pasien epilepsi terbanyak pada golongan usia dewasa muda (usia 18-25 tahun; 30,5%), laki-laki (55,6%), tingkat pendidikan terakhir SMA (44,4%), tidak bekerja (50%), dan belum menikah (52,8%). Kebanyakan onset epilepsi pada usia 19-60 tahun (58,3%), dengan frekuensi bangkitan tidak sering (75%). Sebagian besar pasien teratur minum obat anti-epilepsi (77,8%) dan telah didiagnosis epilepsi selama 15-30 tahun (44,4%). Sebanyak 9 (25%) pasien epilepsi mengalami penurunan fungsi kognitif yang nyata dan 17 orang (47,2%) kemungkinan (probable) mengalami penurunan fungsi kognitif. Uji korelasi Kendal tau menghasilkan adanya hubungan antara usia saat onset dan fungsi kognitif (p<0,004). Simpulan: Terdapat hubungan antara usia onset dan fungsi kognitif pada pasien epilepsi di Poliklinik Saraf RSUD dr. Soedarso kota Pontianak. Background: Epilepsy is a central nervous system disorder characterized by spontaneous recurrent seizures. Age at onset is one of the factors that may influence cognitive function in epilepsy patients. Aim: To search the relationship between the age at onset and cognitive function among epilepsy patients in the Neurology Polyclinic, dr. Soedarso Regional Hospital, Pontianak City, Indonesia. Methods: An analytic observational study with a cross-sectional method. The total subjects were 36 patients. The independent variable was the age of patients at diagnosis, and the dependent variable was cognitive function. Results: Most epilepsy patients were in young adult age (18-25 years; 30.5%), male (55.6%), with high school as the highest level of education (44.4%), unemployed (50%), and not married (52.8%). The onset of epilepsy is mostly at 19 to 60 years old (58.3%), with infrequent seizure frequency (75%). Most patients are regularly taking anti-epileptic drugs (77.8%), and have been diagnosed for 15-30 years (44.4%). A total of 9 (25%) patients experienced a marked decline in cognitive function, and 17 people (47.2%) experienced a probable decline in cognitive function. Kendal tau correlation test resulted in a relationship between the age at onset and cognitive function (p<0.004). Conclusion: There is a relation between the age at onset and cognitive function among epilepsy patients in dr. Soedarso Regional Hospital of Pontianak City.

Title

Found 4 Documents
Search

Abstract

Abstract

Abstract

Abstract

Title Search

Found 4 Documents Search

Abstract

Abstract

Abstract

Abstract

Title

Found 4 Documents
Search