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All Journal Jurnal Syntax Transformation Cermin Dunia Kedokteran Cermin Dunia Kedokteran
Diana Wijayati
Departement Of Dermatology And Venereology, Cibabat Hospital Cimahi West Java, Indonesia
Humanities Education Environmental Science Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences

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Diagnostic Approach to Keratoacanthoma : Differentiating with Squamous Cell Carcinoma Firda Fakhrena; A.A Ayu Adisti Nina Yuniandari; Rafdi Ahmed; Diana Wijayati
Jurnal Syntax Transformation Vol 3 No 11 (2022): Jurnal Syntax Transformatin
Publisher : CV. Syntax Corporation Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/jst.v3i11.644

Abstract

Keratoacanthoma (KA) is a cutaneous neoplasms from the pilosebaseous unit, characterized as a rapidly growing tumor and usually show spontaneous regression. A major difficulty in dealing with these neoplasms is to differentiating them from squamous cell carcinoma, clinically and histologically. However, the change for regression has led keratoacanthoma as benign tumors with different pathophysiological mechanism from cutaneous squamous cell carcinoma (cSCC). The similarities between keratoacanthoma and cSCC, especially the well-differentiated variant cSCC, has led to the general recommendation for surgical excision of keratoacanthoma to make sure that a potentially malignant cSCC is not left untreated. Differentiating KA with cSCC would change management strategies to the less invasive treatment modalities, prevent surgical morbidity, and reduce healthcare costs. Methods : We searched for relevant journal articles in PubMed with a systematic search using PICO, with the keyword “Keratoacanthoma“ or “Squamous cell carcinoma“ and “Diagnostic“ or “History, physical examination, histology“. We got 825 publications and we filtered by the last five years and we generated 12 publications from 2017-2022 after we checked from the title and abstract for relevancy. Conclusion : The review revealed that keratoacanthoma can be distinguished from squamous cell carcinoma from the biological differences of spontaneous regression, very rapid growth and the absence of malignant features. It can also be distinguished by the histological and immunohistochemistry examination such as the presence of epithelial lips, neutrophilic microabscesses within the atypical epithelium, firm boundaries between tumor and stroma, ulceration, many mitotic cells and pleomorphic or anaplastic. The study also show that CD1a and Hsp60 can help distinguish between KA and SCC.
Generalized Pustular Psoriasis in a 4 Year-old Boy Rievanda; Ayu Natasya; Diana Wijayati
Cermin Dunia Kedokteran Vol 49 No 12 (2022): Dermatologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v49i12.326

Abstract

Background: Generalized pustular psoriasis (GPP) is a variant of psoriasis characterized by widespread erythematous skin studded with sterile pustules. In general, PPG is rare in children. Diagnosis is made from the clinical and histopathological examination. The rarity of GPP in children has resulted in a need for standardized guidelines. Case: A 4 year-old boy with a generalized pustular eruption and confluent scaly plaques on erythematous skin. Mild pruritus and general malaise were present. Histopathological examination confirmed diagnosis of GPP. Clinical improvement was achieved with a combination of topical corticosteroids, anti-histamine, and systemic corticosteroids for two weeks. Conclusion: A combination of topical corticosteroids, anti-histamine, and systemic corticosteroids can still achieve clinical improvement in children with GPP. Nevertheless, its adverse effects should always be considered, and strict monitoring is required. Latar Belakang: Psoriasis pustulosa generalisata (PPG) merupakan salah satu varian klinis psoriasis yang ditandai oleh kulit eritema disertai erupsi pustul steril yang tersebar luas. Pada umumnya, PPG jarang pada anak-anak. Diagnosis berdasarkan pemeriksaan klinis dan histopatologis. Jarangnya kasus PPG pada anak-anak menyebabkan kurangnya pedoman tata laksana terstandarisasi. Kasus: Seorang anak laki-laki berusia 4 tahun dengan kelainan kulit berupa erupsi pustulosa generalisata beserta kumpulan plak berskuama pada dasar kulit eritema. Keluhan disertai gatal ringan serta rasa lemah dan lesu. Pemeriksaan histopatologis memperkuat diagnosis PPG. Perbaikan klinis tercapai dengan tata laksana kombinasi corticosteroid topikal, anti-histamin, dan corticosteroid sistemik selama 2 minggu. Simpulan: Kombinasi corticosteroid topikal, anti-histamin, dan corticosteroid sistemik mampu menghasilkan perbaikan klinis pada anak-anak dengan PPG. Meskipun demikian, efek sampingnya harus selalu diperhitungkan dan membutuhkan pengawasan ketat.
Generalized Pustular Psoriasis in a 4 Year-old Boy Rievanda; Ayu Natasya; Diana Wijayati
Cermin Dunia Kedokteran Vol 49 No 12 (2022): Dermatologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v49i12.326

Abstract

Background: Generalized pustular psoriasis (GPP) is a variant of psoriasis characterized by widespread erythematous skin studded with sterile pustules. In general, PPG is rare in children. Diagnosis is made from the clinical and histopathological examination. The rarity of GPP in children has resulted in a need for standardized guidelines. Case: A 4 year-old boy with a generalized pustular eruption and confluent scaly plaques on erythematous skin. Mild pruritus and general malaise were present. Histopathological examination confirmed diagnosis of GPP. Clinical improvement was achieved with a combination of topical corticosteroids, anti-histamine, and systemic corticosteroids for two weeks. Conclusion: A combination of topical corticosteroids, anti-histamine, and systemic corticosteroids can still achieve clinical improvement in children with GPP. Nevertheless, its adverse effects should always be considered, and strict monitoring is required. Latar Belakang: Psoriasis pustulosa generalisata (PPG) merupakan salah satu varian klinis psoriasis yang ditandai oleh kulit eritema disertai erupsi pustul steril yang tersebar luas. Pada umumnya, PPG jarang pada anak-anak. Diagnosis berdasarkan pemeriksaan klinis dan histopatologis. Jarangnya kasus PPG pada anak-anak menyebabkan kurangnya pedoman tata laksana terstandarisasi. Kasus: Seorang anak laki-laki berusia 4 tahun dengan kelainan kulit berupa erupsi pustulosa generalisata beserta kumpulan plak berskuama pada dasar kulit eritema. Keluhan disertai gatal ringan serta rasa lemah dan lesu. Pemeriksaan histopatologis memperkuat diagnosis PPG. Perbaikan klinis tercapai dengan tata laksana kombinasi corticosteroid topikal, anti-histamin, dan corticosteroid sistemik selama 2 minggu. Simpulan: Kombinasi corticosteroid topikal, anti-histamin, dan corticosteroid sistemik mampu menghasilkan perbaikan klinis pada anak-anak dengan PPG. Meskipun demikian, efek sampingnya harus selalu diperhitungkan dan membutuhkan pengawasan ketat.
Co-Authors A.A Ayu Adisti Nina Yuniandari Ayu Natasya Boy Rievanda Firda Fakhrena Rafdi Ahmed