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All Journal Cermin Dunia Kedokteran Neurona Cermin Dunia Kedokteran
Daniel Mahendrakrisna
RSUD Kota Surakarta, Surakarta, Indonesia
Health Professions Medicine & Pharmacology Neuroscience Public Health

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Keracunan Tanaman Kecubung Daniel Mahendrakrisna; Khadijah Nur Al Firdausi
Cermin Dunia Kedokteran Vol 47 No 9 (2020): Infeksi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v47i9.566

Abstract

Keracunan tanaman Datura stramonium atau yang dikenal sebagai tanaman Kecubung di Indonesia, merupakan tanaman yang sering digunakan sebagai pengobatan; tanaman ini dapat disalahgunakan sebagai zat psikotropika. Gejala klinis kasus ini adalah gejala peningkatan saraf parasimpatis berupa midriasis, kulit kering, dan takikardia. Tatalaksana keracunan tanaman Kecubung bersifat suportif, umumnya akanmembaik sendiri; jika berat dapat diberi reversible cholinesterase inhibitor seperti physostigmine. Datura stramonium, known as Kecubung flower in Indonesia, is a plant often used as a medicine; this plant is also often abused as psychotropics. The clinical symptoms in this case are increased parasympathetic activities such as mydriasis, dry skin, and tachycardia. Datura intoxication treatment is supportive, generally will get better on its own. In severe cases, reversible cholinesterase inhibitor such as physostigmine should be used.
Tatalaksana Epilepsi Refrakter Daniel Mahendrakrisna; Rizaldy Taslim Pinzon
Cermin Dunia Kedokteran Vol. 47 No. 7 (2020): Neurologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v47i7.595

Abstract

Epilepsi refrakter atau resisten obat didefinisikan sebagai kegagalan respons terhadap dua obat anti-epilepsi sesuai jadwal, dosis, dan rute pemberian, baik monoterapi maupun kombinasi, untuk tercapainya bebas serangan. Serangan epilepsi yang tidak terkontrol atau resisten obat umumnya berkaitan dengan prognosis buruk, dan mengganggu kualitas hidup. Beberapa pilihan terapi kasus epilepsi refrakter, yaitu diet ketogenik, deep brain stimulator (DBS), vagal nerve stimulator (VNS), transcranial magnetic stimulation (TMS), responsive cortical neuro-stimulator (RNS), dan pembedahan. Terapi lini pertama adalah pembedahan reseksi. Refractory epilepsy is defined as epilepsy unresponsive to two or more anti epileptic drugs with proper schedule doses, and route of administration on monotherapy and combined therapy, to achieve seizures freedom. Refractory epilepsy was associated with poor prognostic and decreased quality of life. Several alternatives for refractory epilepsy are ketogenic diet, Deep Brain Stimulator (DBS), Vagal Nerve Stimulator (VNS), Transcranial Magnetic Stimulation (TMS), Responsive Cortical Neuro-Stimulator (RNS), and surgery. The first line therapy for refractory epilepsy is resection surgery.
KORELASI KADAR ASAM URAT DALAM DARAH TERHADAP LUARAN KLINIS STROKE ISKEMIK AKUT Daniel Mahendrakrisna; Aria Chandra Gunawan Triwibowo Soedomo
NEURONA Vol 38 No 1 (2020)
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Uric acid is an end metabolism product of purine. It has been known as an important antioxidant in the serum. Correlation between uric acid serum with stroke has been reported controversial finding. However, Uric acid has been proposed to be a stroke risk factor. Aim: To determine the correlation between uric acid serum levels and acute stroke ischemic outcome. Method: This was a cross-sectional study at Surakarta Hospital. All of first experience stroke ischemic patients proven by CT-Scan were included as subjects. Demographic data (age, sex, blood pressure, etc) and laboratory results such as uric acid 24 hours, blood glucose test (random glucose test and fasting glucose test), lipid profile (cholesterol, triglyceride) were obtained from medical records. Data was analysed by software and p<0.05 was statistically accepted. Results: Of 49 acute stroke ischemic patients were include to this study. The mean of uric acid level serum as 5.71±2.64 mg/dL. 30,6% subjects had hyperuricemia and 8,2% subjects had hypouricemia. There were no correlation between uric acids levels with stroke clinical outcome (r= 0.08, p>0.05). Conclusion: There was no correlation between uric acid serum levels and acute stroke ischemic outcome.. Keywords: Ischemic, Modified Rankin Scale,
Keracunan Tanaman Kecubung Daniel Mahendrakrisna; Khadijah Nur Al Firdausi
Cermin Dunia Kedokteran Vol 47 No 9 (2020): Infeksi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v47i9.566

Abstract

Keracunan tanaman Datura stramonium atau yang dikenal sebagai tanaman Kecubung di Indonesia, merupakan tanaman yang sering digunakan sebagai pengobatan; tanaman ini dapat disalahgunakan sebagai zat psikotropika. Gejala klinis kasus ini adalah gejala peningkatan saraf parasimpatis berupa midriasis, kulit kering, dan takikardia. Tatalaksana keracunan tanaman Kecubung bersifat suportif, umumnya akanmembaik sendiri; jika berat dapat diberi reversible cholinesterase inhibitor seperti physostigmine. Datura stramonium, known as Kecubung flower in Indonesia, is a plant often used as a medicine; this plant is also often abused as psychotropics. The clinical symptoms in this case are increased parasympathetic activities such as mydriasis, dry skin, and tachycardia. Datura intoxication treatment is supportive, generally will get better on its own. In severe cases, reversible cholinesterase inhibitor such as physostigmine should be used.
Tatalaksana Epilepsi Refrakter Daniel Mahendrakrisna; Rizaldy Taslim Pinzon
Cermin Dunia Kedokteran Vol 47 No 7 (2020): Neurologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v47i7.595

Abstract

Epilepsi refrakter atau resisten obat didefinisikan sebagai kegagalan respons terhadap dua obat anti-epilepsi sesuai jadwal, dosis, dan rute pemberian, baik monoterapi maupun kombinasi, untuk tercapainya bebas serangan. Serangan epilepsi yang tidak terkontrol atau resisten obat umumnya berkaitan dengan prognosis buruk, dan mengganggu kualitas hidup. Beberapa pilihan terapi kasus epilepsi refrakter, yaitu diet ketogenik, deep brain stimulator (DBS), vagal nerve stimulator (VNS), transcranial magnetic stimulation (TMS), responsive cortical neuro-stimulator (RNS), dan pembedahan. Terapi lini pertama adalah pembedahan reseksi. Refractory epilepsy is defined as epilepsy unresponsive to two or more anti epileptic drugs with proper schedule doses, and route of administration on monotherapy and combined therapy, to achieve seizures freedom. Refractory epilepsy was associated with poor prognostic and decreased quality of life. Several alternatives for refractory epilepsy are ketogenic diet, Deep Brain Stimulator (DBS), Vagal Nerve Stimulator (VNS), Transcranial Magnetic Stimulation (TMS), Responsive Cortical Neuro-Stimulator (RNS), and surgery. The first line therapy for refractory epilepsy is resection surgery.
Co-Authors Aria Chandra Gunawan Triwibowo Soedomo Khadijah Nur Al Firdausi Rizaldy Taslim Pinzon