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All Journal Viva Medika: Jurnal Kesehatan, Kebidanan dan Keperawatan Pharmacy Genius Jurnal Farmasi Ikifa JIFTK (Jurnal Ilmu Farmasi Terapan dan Kesehatan)
Sunarti
Universitas Harapan Bangsa
Chemistry Health Professions Medicine & Pharmacology Nursing Public Health

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Formulasi Dan Evaluasi Gel Antijerawat Ekstrak Etanol Kulit Pisang Ambon Lumut (Musa Acuminata Colla ) Dengan Variasi Konsentrasi Cmc- Na Sebagai Gelling Agent Nur Rifka Zaneta; Rani Prabandari; Sunarti
Pharmacogenius Journal Vol 1 No 1 (2022): Pharmacy Genius
Publisher : Yayasan Inspirasi El Burhani

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (646.746 KB) | DOI: 10.56359/pharmgen.v1i01.148

Abstract

ABSTRAK Pendahuluan: Ekstrak etanol kulit pisang ambon lumut memiliki kandungan flavonoid, saponin dan tanin yang berperan sebagai antibakteri. Jerawat sangatlah mengganggu penampilan seseorang sehingga mulai banyak yang memilih pengobatan sintetik karena efek samping yang ditimbulkan lebih ringan. Sediaan yang cocok untuk mengobati kulit berjerawat yaitu gel. Tujuan: Tujuan penelitian ini untuk mengetahui sifat fisik dan daya hambat gel antijerawat ekstrak etanol kulit pisang ambon lumut terhadap pertumbuhan bakteri Staphylococcus aureus ATCC 25923. Metode: Penelitian ini dilaksanakan dengan metode eksperimental. Kegiatan yang dilakukan adalah pembuatan ekstrak etanol kulit pisang ambon lumut secara maserasi, pembuatan sediaan gel dengan konsentrasi ekstrak etanol kulit pisang ambon lumut 16 % b/b dan variasi CMC-Na FI (3%), F II (4%) dan FIII (5%), dilakukan uji sifat fisik yang meliputi uji organoleptik, uji homogenitas,uji pH, uji daya sebar, dan uji viskositas. Formula optimum diuji zona hambatnya menggunakan metode kertas cakram. Kemudian dianalisis menggunakan SPSS. Hasil: Formula optimum yang memenuhi semua parameter sediaan gel baik sebelum stabilitas maupun sesudah stabilitas yaitu formula I dengan konsentrasi CMC-Na 3% karena memenuhi perameter uji homogeitas, uji organoleptis, uji pH, uji daya lekat, uji daya sebar dan uji viskositas. Hasil daya hambat formula optimum FI sebesar 4,47 mm termasuk respon hambatan lemah. Hasil analisis SPSS berdasarkan uji one way anova pada nilai ph p>0,05. Sedangkan pada nilai daya lekat, daya sebar dan p<0,05.
Formulasi Tablet Kunyah Asetosal Dengan Variasi Konsentrasi Gelatin Sebagai Bahan Pengikat Terhadap Uji Fisik Tablet Kinanthi Dwi Utami; Rani Prabandari; Sunarti
Jurnal Farmasi IKIFA Vol. 2 No. 2 (2023): JURNAL FARMASI IKIFA VOL.2 NO.2 OKTOBER TAHUN 2023
Publisher : Sekolah Tinggi Ilmu Kesehatan IKIFA

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Abstract

Acetosal, a nonsteroidal anti-inflammatory drug that is included in the category of drugs with a dose of 80 mg. In patients with coronary heart disease and severe hypertension, this drug is used as antiplatelet therapy with the aim of preventing stroke. Acetosals are included in the BCS class II category, so efforts are needed to develop formulations that can increase the speed of dissolution and provide a fast effect. This study aims to determine the variation in gelatin concentration as a binding agent to physical properties and determine the best gelatin concentration that meets the dissolution test of acetosal chewable tablets. The method used to make acetosal chewable tablets is direct felt. Acetosal chewable tablets are made into 3 formulas with variations in the concentration of gelatin binders of 2%, 6%, and 10%. The data obtained is then analyzed with one-way ANOVA. The results showed variations in gelatin concentrations of 2%, 6%, and 10% resulting in good physical properties of acetosal chewable tablets. The gelatin concentration of 2% in formula 1 showed the best results with an average test value of uniformity of weight 220.6 ± 1.42 mg, uniformity of diameter size 0.838 ± 0.01 cm, and thickness 0.436 ± 0.01 cm, hardness 4.3 ±0.15 kg, brittleness 0.49 ± 0.32%, crushing time 31 ± 3.0 seconds and dissolution 95.81%. A significant difference in values was found in the hardness test results (p = 0.001) and the time of destruction (p = 0.000). The best percent dissolution is found in Formula 1 with a dissolution value of 95.81%.
STUDI TOKSISITAS AKUT EKSTRAK ETANOL BUNGA TELANG (Clitoria ternatea L.) PADA TIKUS PUTIH Vinda Merlani; Dina Febrina; Sunarti
Jurnal Ilmu Farmasi Terapan dan Kesehatan Vol. 2 No. 1 (2024): Jurnal Ilmu Farmasi Terapan dan Kesehatan Vol.2 No.1 2024
Publisher : Sekolah Tinggi Ilmu Kesehatan IKIFA

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Abstract

Sejak zaman dahulu bahan alami atau obat tradisional, terutama yang diperoleh dari tumbuhan, telah dimanfaatkan secara turun-temurun sebagai sumber pengobatan dan pencegahan penyakit. Salah satu contoh obat tradisional yang berasal dari tumbuhan adalah bunga telang, yang memiliki potensi efek farmakologis yang signifikan untuk mengobati berbagai jenis penyakit. Suatu senyawa tanaman dapat dianggap aman jika lolos uji toksisitas pada hewan coba dan secara klinis aman untuk dikonsumsi, oleh karena itu, sangat penting untuk mengetahui LD50 dan spektrum efek toksik. Metode penelitian yang dilakukan secara eksperimental meliputi pembuatan ekstrak, uji toksisitas akut ekstrak bunga telang dengan metode fixed dose. Berdasarkan hasil penelitian, uji pemberian ekstrak etanol dari bunga telang tidak menunjukkan adanya bukti toksisitas, berdasarkan kriteria masuk kategori 5/unclassified dan ekstrak etanol bunga telang termasuk kategori toksik sedang karena mempunyai nilai LD50 >2000 mg/KgBB.
Analysis of Antidiabetic Drug Utilization at Cilacap Regional General Hospital in 2022 Using ATC/DDD and DU90% Methods Irma Nur Oktavina; Sunarti; Galih Samodra
Viva Medika Vol 17 No 1 (2024)
Publisher : LPPM Universitas Harapan Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35960/vm.v17i1.1349

Abstract

Diabetes mellitus is a chronic disease caused by metabolic disorders characterized by elevated blood glucose levels or hyperglycemia. The aim of diabetes mellitus treatment is to control blood glucose levels within the normal range, eliminate accompanying clinical symptoms, and reduce the risk of acute complications. To achieve therapeutic goals, pharmacological therapy can be administered using antidiabetic drugs. This research is an observational study involving retrospective data collection of outpatients with type 2 diabetes mellitus who used antidiabetic drugs. The prescribed antidiabetic drugs were then analyzed using the Anatomical Therapeutic Chemical (ATC) and Defined Daily Dose (DDD) methods. Data on antidiabetic drugs were collected and entered into the Microsoft Excel program to calculate the DDD/1000 KPRJ value and the 90% Du segment. The results showed that there were 7 antidiabetic drugs used, namely glimepiride, gliquidone, gliclazide, metformin, acarbose, vildagliptin, and pioglitazone, with glimepiride having the highest DDD value of 445.92 DDD/1000 KPRJ and gliquidone having the lowest DDD value of 128.70 DDD/1000 KPRJ. Meanwhile, glimepiride and metformin were the antidiabetic drugs included in the 90% Du segment.
Drug Utilization Analysis in Stroke Patients at Cilacap Regional Public Hospital Using the ATC/DDD Method and DU 90% Argi Asih; Sunarti; Khamdiyah Indah Kurniasih
Viva Medika Vol 17 No 1 (2024)
Publisher : LPPM Universitas Harapan Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35960/vm.v17i1.1353

Abstract

Stroke is a serious medical condition in which the blood supply to the brain is disrupted, leading to the death of brain cells. The use of stroke medications aims to prevent and treat thromboembolism, and the increased use of stroke medications reflects the high global morbidity and mortality rates. This study aims to describe the utilization of drugs for stroke in patients treated at Cilacap Regional Public Hospital in 2022. The research method used was a descriptive study with a retrospective approach, referring to medical record data. A total of 167 samples were taken by purposive sampling, and the samples were evaluated using the ATC/DDD method and DU 90%. The results showed that the highest DDD/100 bed days value was for oral Acetylsalicylic Acid at 128124.19, and the lowest DDD/100 bed days value was for intravenous Phytomenadione at 6.73. The stroke medication included in the DU 90% was the ischemic stroke drug, oral Acetylsalicylic Acid, with a DU% value of 97.61%. The stroke medications in the 10% segment were the ischemic stroke drugs, namely oral Clopidogrel, oral Cilostazol, and oral Warfarin, as well as the hemorrhagic stroke drugs, intravenous Tranexamic Acid and intravenous Phytomenadione. The DDD per 100 bed days value for stroke medications exceeded the WHO's appropriateness criteria.
Activity Test of 96% Ethanol Extract of Water Guava Leaf (Syzygium aqueum) on LDL and HDL Values with Propylthiouracil Induction in Rats Siti Setianingsih; Sunarti; Muhammad Maulana
Viva Medika Vol 17 No 2 (2024)
Publisher : LPPM Universitas Harapan Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35960/vm.v17i2.1472

Abstract

One of the plants that can be thought to have antihyperlipidemic potential is water guava leaves (Syzygium aqueum) because they contain chemical compounds, one of which is flavonoids. The aim of this research is to determine the activity of 96% ethanol extract of water guava leaves (EEDJA) as an antihyperlipidemic agent. Male Wistar rats were induced using propylthiouracil (PTU) for 2 weeks (14 days). Hyperlipidemic mice were divided into 5 test groups, CMC-Na group, simvastatin group, EEDJA group (100, 200 and 400) mg/BW. The solution was given to mice routinely once a day for 2 weeks (14 days) orally. The results of the study showed that there were differences before and after administration of EEDJA (100, 200 and 400) mg/BW in LDL and HDL levels with a significance value of 0.000 (<0.005). The conclusion from this study is that EEDJA has potential as an antihyperlipidemic agent in male white Wistar rats
Co-Authors Argi Asih dina febrina Galih Samodra Irma Nur Oktavina Khamdiyah Indah Kurniasih Kinanthi Dwi Utami Muhammad Maulana Nur Rifka Zaneta Rani Prabandari Siti Setianingsih Vinda Merlani