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All Journal Pharmacy Genius Pharmacon: Jurnal Farmasi Indonesia
Sunarti
Universitas Harapan Bangsa
Chemistry Health Professions Medicine & Pharmacology

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Formulasi Dan Evaluasi Gel Antijerawat Ekstrak Etanol Kulit Pisang Ambon Lumut (Musa Acuminata Colla ) Dengan Variasi Konsentrasi Cmc- Na Sebagai Gelling Agent Nur Rifka Zaneta; Rani Prabandari; Sunarti
Pharmacogenius Journal Vol 1 No 1 (2022): Pharmacy Genius
Publisher : Yayasan Inspirasi El Burhani

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (646.746 KB) | DOI: 10.56359/pharmgen.v1i01.148

Abstract

ABSTRAK Pendahuluan: Ekstrak etanol kulit pisang ambon lumut memiliki kandungan flavonoid, saponin dan tanin yang berperan sebagai antibakteri. Jerawat sangatlah mengganggu penampilan seseorang sehingga mulai banyak yang memilih pengobatan sintetik karena efek samping yang ditimbulkan lebih ringan. Sediaan yang cocok untuk mengobati kulit berjerawat yaitu gel. Tujuan: Tujuan penelitian ini untuk mengetahui sifat fisik dan daya hambat gel antijerawat ekstrak etanol kulit pisang ambon lumut terhadap pertumbuhan bakteri Staphylococcus aureus ATCC 25923. Metode: Penelitian ini dilaksanakan dengan metode eksperimental. Kegiatan yang dilakukan adalah pembuatan ekstrak etanol kulit pisang ambon lumut secara maserasi, pembuatan sediaan gel dengan konsentrasi ekstrak etanol kulit pisang ambon lumut 16 % b/b dan variasi CMC-Na FI (3%), F II (4%) dan FIII (5%), dilakukan uji sifat fisik yang meliputi uji organoleptik, uji homogenitas,uji pH, uji daya sebar, dan uji viskositas. Formula optimum diuji zona hambatnya menggunakan metode kertas cakram. Kemudian dianalisis menggunakan SPSS. Hasil: Formula optimum yang memenuhi semua parameter sediaan gel baik sebelum stabilitas maupun sesudah stabilitas yaitu formula I dengan konsentrasi CMC-Na 3% karena memenuhi perameter uji homogeitas, uji organoleptis, uji pH, uji daya lekat, uji daya sebar dan uji viskositas. Hasil daya hambat formula optimum FI sebesar 4,47 mm termasuk respon hambatan lemah. Hasil analisis SPSS berdasarkan uji one way anova pada nilai ph p>0,05. Sedangkan pada nilai daya lekat, daya sebar dan p<0,05.
Anti-Inflammatory Activity Test fo Ethanol Extract of Kluwih Leaves (Artocarpus camansi Blanco) on Male Wistar White Rats (Rattus norvegicus) Laela Suci Nofiyanti; Sunarti; Galih Samodra
Pharmacon: Jurnal Farmasi Indonesia Vol. 21 No. 1 (2024)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v21i1.2920

Abstract

Inflammation occurs when the body reacts to infection, irritation, or other damage. Some compounds in kluwih leaves are believed to have anti-inflammatory potential, one of which is flavonoids. The aim of this study was to find out the activity and effective dosage of the ethanol extract from kluwih leaves as an anti-inflammatory in male white Wistar rats. The experimental animals were divided into five groups: the negative control group (0.5% Na-CMC), the positive control group (Na-diclofenac), and the three treatment groups were given ethanol extract from kluwih leaves at doses of 175, 350, and 700 mg/KgBW orally. After 30 minutes, the soles of the rats' feet were induced with 0.1 ml of 1% carrageenan subplantarly. Edema volume was assessed every 1 hour for 6 hours using a plethysmometer. The data was statistically analyzed using One-Way ANOVA with LSD post hoc test. The research data shows that the ethanol extract of kluwih leaves at doses 175, 350, and 700 mg/KgBW has anti-inflammatory activity. The effective dose of kluwih leaf ethanol extract was 700 mg/KgBW (28.68%) with the second highest percentage of anti-inflammatory power value after the positive control group (31.75%). The LSD (Least Significant Difference) results indicate that the ethanol extract of kluwih leaf at a dose of 700 mg/KgBW does not show a significant difference in its anti-inflammatory effect with the positive control (0.442>0.05).
Co-Authors Galih Samodra Laela Suci Nofiyanti Nur Rifka Zaneta Rani Prabandari