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BS Muddukrishna
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Medicine & Pharmacology

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FUNCTIONALITY EVALUATION OF EXCIPIENTS MANUFACTURED BY DIFFERENT MANUFACTURERS BS Muddukrishna
Journal of Global Pharma Technology Volume 08 Issue 10: (2016) October 2016
Publisher : Journal of Global Pharma Technology

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Abstract

Purpose: The main aim of this article is to develop an alternate source for excipients manufactured bydifferent manufacturers. Methods: Four different excipients were selected for this study and evaluated based on theirfunctional characteristics. Results: From the results obtained, the both vendors of the materials were showingequivalent each other when we compared with the monograph specifications, analytical results and functionalitycharacteristics. Conclusion: Functionality evaluation of excipients were determined based on the specificationcomparison, analytical results comparison and finally with functionality characteristics of excipients and their impacton formulation.
RP-HPLC Method Development and Validation for the Estimation of Methylcobalamin in Bulk BS Muddukrishna
Journal of Global Pharma Technology Volume 09 Issue 03
Publisher : Journal of Global Pharma Technology

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The subsequent artefact entail of extremely subtle and informal Reversed phase HPLC (RP-HPLC) technique for approximation ofMethylcobalamin in large quantity. Shimadzu LC-20-AD(Kyoto, Japan), with auto sampler and (PDA/UV) detector was used for the separation of Methylcobalamin.C18 Hypersil BDS (5.0 micron,150 x 4.6mm) column was aimed at the separation and mobile phase(MP) comprising of(55:45 v/v) Methanol:o-phosphoric acid 0.02%v/v pH 2.3 was cast-offby keeping the rate offlow1 ml/minalong the effluents supervised on 223nm. linearity is undeviating having line equationf(x) =4.87512e-006*x-0.702284 with correlation coefficient(R2) of 0.997. Theprocessremained precise with 0.5% RSD(intra-day precision)&(Inter-day precision) is 0.43%. The LOD & LOQ was0.1499μg/ml and 0.4542μg/ml respectively.The establishedprocess wasvalidated forlinearity,system suitability,precision, and robustness; henceforthverifies in order that this one is exceedinglyrelevantto approximate Methylcobalamin in routine analysis.Methods name: Estimation of Methylcobalaminby HPLC.Keywords: Methylcobalamin, Reverse phase hplc (RP-HPLC), Validation and chromatography.
METHOD DEVELOPMENT AND VALIDATION FOR THE ESTIMATION OF TICARGRELOR IN BULK AND COMPARISON WITH OTHER PUBLISHED METHODS BS Muddukrishna
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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The following article consist of highly sensitive and easy RP-HPLC method to estimate Ticagrelor in bulk. Ticagrelor was separated using Shimadzu LC-20-AD with auto sampler and PDA/UV detector. The separation was achieved using a C18 Vydac Monomeric 120A (5.0 micron, 250 x 4.6mm) column. Acetonitrile: Water Milli Q (60:40 v/v) at a flow rate of 1.0 ml/min was used as the mobile phase. The method was linear having line equation f(x)=1.90442e-005*x-0.302059 with correlation coefficient (R2) of 0.997. The method was precise having  RSD as 0.27% (intraday precision). The LOD & LOQ were 0.083μg/mL and 0.25μg/mL respectively. The developed method was validated for precision, linearity, system suitability and robustness; hence proves that it is highly applicable to estimate Ticagrelor in day to day analysis.
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