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Aamer. M. Ali
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Medicine & Pharmacology

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Evaluate Toxic Effect of Bisphenol A on Kidney of Male Mice and Mitigation Its Effect by Green Tea Extract Aamer. M. Ali
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Bisphenol A is a substance for the synthesis variety of plastics, primarily epoxy resins and polycarbonates. Bisphenol can have severe effects on the type and might contribute to gradual cumulative renal injury over a lifetime. This study object to estimate toxic effect of bisphenol A on type of male mice also mitigation toxic effect of bisphenol A by using extract green tea. Healthy adult male albino laboratory mice (Mus musculus) treated for two doses of bisphenol a (20 mg/kg and 40 mg/kg body weight per day) for thirty days and green tea extract was co-administration orally as antioxidant. Bio-chemical parameter of serum creatinine and blood urea was calculated as indicator of kidney function. groups treated with bisphenol A showed increased in serum creatinine and blood urea also histopathological of kidney showed significant damage in groups that treated with bisphenol A whereas groups that treated with bisphenol A and co-administration  green tea extract showed mitigation toxic effect of bisphenol  A due to role of green tea as anti-oxidant compound.Keywords:  Evaluate, Bisphenol A, Green Tea, Antioxidant compound.
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