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All Journal Jurnal Kesehatan Bakti Tunas Husada Pharmacology and Clinical Pharmacy Research Pharmacy Reports
Muharam Priatna, Muharam
Program Studi S1 Farmasi STIKes Bakti Tunas Husada, Tasikmalaya
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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PENGARUH REBUSAN AKAR BAYAM DURI ( Amaranthus spinosus L.) TERHADAP DIARE PADA MENCIT JANTAN GALUR SWISS WEBSTER DENGAN METODE TRANSIT INTESTINAL Priatna, Muharam
Jurnal Kesehatan Bakti Tunas Husada: Jurnal Ilmu-ilmu Keperawatan, Analis Kesehatan dan Farmasi Vol 16, No 1 (2016): Agustus 2016
Publisher : STIKes BTH Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (217.562 KB) | DOI: 10.36465/jkbth.v16i1.166

Abstract

Telah dilakukan uji aktivitas antidiare dari akar bayam duri (Amaranthus spinosus L) pada mencit jantan galur Swiss Webster. Metode yang digunakan adalah metode transit intestinal. Dosis yang digunakan adalah dosis uji I sebesar 0,039 gram/20 gram BB mencit, dosis uji II 0,078 garm/20 gram BB mencit, dan dosis uji III sebesar 0,156 gram/20 gram BB mencit. Sebagai pembanding digunakan loperamid sebesar 0,78 mgram loperamid. Pemberian seluruh dosis dilakukan secara oral. Hasil penelitian menunjukan bahwa seluruh dosis uji memiliki aktivitas antidiare. Dosis uji II merupakan dosis yang paling baik dibandingkan dosis uji yang lain, meskipun aktivitasnya masih dibawah altivitas loperamid sebagai pembanding. Dosis ini sesuai dengan dosis empiris 30 gram akar bayam duri, semestara dosis empiris yang dianjurkan adalah 30-60 gram.
Off-Label Drug Use in Acute Respiration Infection Patient at Pangandaran Hospital, Pangandaran District, West Java - Indonesia Rahayuningsih, Nur; Priatna, Muharam; Sulistiani, Dewi A.
Pharmacology and Clinical Pharmacy Research Vol 8, No 3 (2023)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v8i3.48103

Abstract

Acute respiratory infections (ARIs) are infectious diseases of the upper or lower respiratory tract that cause a spectrum of illnesses from mild to severe infections. ARI is one of the leading causes of death in children in developing countries. The high incidence of ARI in children results in the use of off-label drugs. Off-label medicine is the use of drugs outside the provisions of the license relating to dose, age, route of administration, contraindications. This study aims to determine the use of off-label drugs in children with a diagnosis of ARI at Pandega Pangandaran Hospital, Pangandaran District, West Java - Indonesia. This study was an observational study with a cross sectional design and data collection was done retrospectively using Chi-square data analysis with a significance level of 0.05. Of the 84 patients who fit the inclusion criteria, there was an off-label drug use of 16.01% with the categories of off-label age (11.16%), off-label dose (4.37%), and off-label indication (0.48%) while in the category of route of administration and contraindications no off-label drug use was found. The most common type of off-label drug used was cetirizine antihistamine.  Based on the results, pharmacist’s supervision related to the risk of drug use is strongly recommended.
Utility analysis of outpatient hypertensive patients with and without comorbidities using the EQ-5D-5L instrument: A study at UPTD Puskesmas Pagerageung, Tasikmalaya Regency, West Java Priatna, Muharam; Maulida, Putri Salma; Alifiar, Ilham
Pharmacy Reports Vol. 4 No. 1 (2024): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.81

Abstract

Hypertension is a chronic condition often requiring lifelong treatment, which can impact patients’ quality of life (QoL) in physical, psychological, and social domains. The presence of comorbid conditions alongside hypertension can further deteriorate QoL. Health utility measurement, particularly in hypertensive patients with comorbidities, is crucial for understanding these compounded effects. This study aims to evaluate and compare the quality of life utility in hypertensive patients with and without comorbidities using the EQ-5D-5L instrument, focusing on how comorbid conditions influence overall QoL. A descriptive observational study with a cross-sectional design was conducted among 100 hypertensive patients treated at UPTD Puskesmas Pagerageung, Tasikmalaya, from January to March 2024. Participants were selected through purposive sampling. The EQ-5D-5L questionnaire was used to assess utility scores, which were calculated using an Indonesian-specific value set. Chi-square and Post Hoc LSD analyses were applied to explore relationships between utility scores and demographic factors such as age, gender, and occupation. The average utility score for hypertensive patients without comorbidities was 0.669, higher than that of patients with comorbid conditions. Specifically, patients with diabetes mellitus, osteoarthritis, gastric conditions, heart disease, and severe comorbidities (e.g., kidney disease, cataracts, stroke) had average scores of 0.578, 0.640, 0.651, 0.537, and 0.148, respectively. Age was significantly associated with utility scores (p = 0.014), whereas gender and occupation showed no significant impact. Hypertensive patients without comorbidities had a better quality of life utility than those with additional health issues. Targeted management of comorbidities is essential to improve the quality of life among hypertensive patients, especially in those facing compounded health challenges.
Co-Authors Dea Yunitasari, Dea Ilham Alifiar, Ilham Maulida, Putri Salma Nur Rahayuningsih, Nur Sulistiani, Dewi A.