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All Journal BALI MEDICAL JOURNAL (BMJ)
D. T. Pardamean, D. T.
Department of Surgery, Neurosurgery Division, Prof. Dr. R. D. Kandou Hospital/School of Medicine, University of Sam Ratulangi, Manado-Indonesia
Medicine & Pharmacology

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THERAPEUTIC MILD HYPOTHERMIA TOWARDS BLOOD LACTATE LEVELS AND GLASGOW COMA SCORE IN SEVERE TRAUMATIC BRAIN INJURY Pardamean, D. T.; Prasetyo, E.; Oley, M.
BALI MEDICAL JOURNAL Vol 4 No 2 (2015)
Publisher : BALI MEDICAL JOURNAL

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Abstract

Background: Raised body temperature is a common occurrence after severe traumatic brain injury (TBI). TBI is accompanied by regional alterations of brain metabolism, reduction in metabolic rates and possible energy crisis. This metabolic disturbance reflected by increase and accumulation of the brain lactate levels. The study aimed to evaluate the effect of therapeutic mild hypotermia (TMH) on lactate levels and GCS (Glasgow Coma Score) of severe TBI. Methods: Fourthy patients with TBI were randomly divided into normothermia (n=20) and mild hypothermia (n=20) group. Body temperature of hypothermia group was maintained at 35°C for 72 hours. Blood lactate level and GCS were determined before and after hypothermia therapy ( on 3th and 7th day). Results: The mean lactate {5.370 vs 4.025 mmol/L, p
Co-Authors E. Prasetyo M. Oley, M.