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All Journal Journal of Agromedicine and Medical Sciences
Jauhar Firdaus
Faculty of Medicine, University of Jember, Jember, Indonesia
Health Professions

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The Effect of Neem (Azadirachta indica) Gum Administration to Malondialdehyde Level of Wistar Rats’ Kidney Induced by Diazinon Jauhar Firdaus; Radinta Maharani Putri; Erfan Efendi; Yuli Hermansyah; Elly Nurus Sakinah
Journal of Agromedicine and Medical Sciences Vol 9 No 1 (2023)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v9i1.35312

Abstract

Diazinon is the most commonly used pesticide in Indonesia. It may increase the production of free radicals that triggers the lipid peroxidation process which will produce the final product, MDA, which can damage cells and tissues, especially the kidneys. Neem gum with its high polysaccharide is a good antioxidant agent to neutralize free radicals. The purpose of this study was to determine the effect of neem gum administration to prevent the increase in kidney MDA levels of wistar rats induced by diazinon. Thirty wistar rats were divided into 6 groups, K0 (given cornoil), K1 (induced DZN 40 mg/kgBW), groups P1, P2, P3, and P4, administered with neem gum as a drinking water at a dose 3.75 g/kgBW, 7.5 g/kgBW, 15 g/kgBW, and 30 g/kgBW and induced by DZN 40 mg/kgBW. The treatment was carried out for 8 days, in which diazinon induction and neem gum solution were administered simultaneously. The average renal MDA levels are K0=20.85±1.10; K1=26.98±5.87; P1=26.84±3.75; P2=21.43±3.44; P3=20.23±3.27; P4=21.99±1.70. One Way ANOVA test showed a significant difference (p<0.05). The LSD posthoc test showed a significant difference in the treatment groups P2, P3, and P4 compared to the K1 group (p<0.05). This shows that the neem gum solution at a dose of 7.5 g/kgBW, 15 g/kgBW, and 30 g/kgBW can prevent the increase of kidney MDA level in wistar rats induced by diazinon. Keywords: Pesticide, oxidative stress, Antioxidant, Neem gum
Diet Reduce Apnea Hypopnea Index (Ahi) Score in Obstructive Sleep Apnea Patient: Systematic Review and Meta-analysis Adella Bintang Saputri; Nindya Shinta Rumastika; Muhammad Afiful Jauhani; Wiwien Sugih Utami; Jauhar Firdaus
Journal of Agromedicine and Medical Sciences Vol 10 No 2 (2024)
Publisher : Faculty of Medicine, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v10i2.38538

Abstract

Obstructive sleep apnea (OSA) is a breathing disorder during sleep that can cause obstruction to the flow of breathing with characteristics such as collapse of the upper airway which can cause breathing to stop, either completely (apnea) or partial (hypopnea). Based on a study of taxi drivers in Jakarta, it was found that 52,5% of the sample had OSA. One of the main factors for OSA is obesity. Based on The American Academy of Sleep Medicine (AASM) recommends weight loss through lifestyle modifications (eg applying diet) as a treatment option for AHI improvement in OSA. The purpose of writing this article is to prove that adopting a diet can reduce the apnea hypopnea index (AHI) of OSA. The method in this study is a systematic review and meta-analysis using secondary data derived from PubMed, Science Direct, and Springer databases published from 2019 to 2022.. A total of six randomized controlled trial (RCT) articles were investigated by meta-analysis The weighted mean difference in AHI (-6,77 event/d with 95% CI: -13,42 to -0,1) significantly favoured diet over control arms. Based on the results of a systematic review and meta-analysis of six articles, the application of a diet is proven to reduce AHI scores in OSA patients. Keywords: Obstructive sleep apnea, Apnea hypopnea index, Diet
Co-Authors Adella Bintang Saputri Elly Nurus Sakinah Erfan Efendi Muhammad Afiful Jauhani Nindya Shinta Rumastika Radinta Maharani Putri Wiwien Sugih Utami Yuli Hermansyah