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All Journal International Journal of Public Health Science (IJPHS) Jurnal Sain Veteriner Jurnal Kesehatan Lingkungan indonesia e-Journal Pustaka Kesehatan Althea Medical Journal Majalah Geografi Indonesia Jurnal Kesehatan Jurnal Kesehatan Andalas Jurnal Berkala Epidemiologi Folia Medica Indonesiana Damianus Journal of Medicine Journal of Agromedicine and Medical Sciences Jurnal Media Gizi Indonesia (MGI) JURNAL KESEHATAN LINGKUNGAN (Journal of Environmental Health) The Indonesian Journal of Occupational Safety and Health UNEJ e-Proceeding Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Jurnal Gizi dan Dietetik Indonesia (Indonesian Journal of Nutrition and Dietetics) Jurnal Manajemen Kesehatan Yayasan RS.Dr. Soetomo Al-sihah: The Public Health Science Journal Jurnal Medik Veteriner Hearty : Jurnal Kesehatan Masyarakat J-Dinamika: Jurnal Pengabdian Kepada Masyarakat Journal of Health Sciences ARTERI : Jurnal Ilmu Kesehatan MAHESA : Malahayati Health Student Journal Solo Journal of Anesthesi, Pain and Critical Care JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Berita Kedokteran Masyarakat Jember Medical Journal (JMJ) Indonesian Journal of Biomedicine and Clinical Sciences Journal of Agropharmacy
Wiwien Sugih Utami
Department Of Parasitology, Faculty Of Medicine, Universitas Of Jember, Jember 68121, Indonesia
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Dentistry Earth & Planetary Sciences Education Electrical & Electronics Engineering Environmental Science Health Professions Immunology & microbiology Library & Information Science Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary Other

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Bioactivity of a Compound of Standardized Bangle (Zingiber cassumunar Roxb.) Extract Fraction as a Complimentary Therapy to Prevent Malaria Complications Hermansyah, Bagus; Utami, Wiwien Sugih
Journal of Agromedicine and Medical Sciences Vol 1, No 2 (2015)
Publisher : Medical Faculty of Jember University (Fakultas Kedokteran Universitas Jember)

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Abstract

Malaria is still a major problem in the international and national scale. World Health Organization (WHO) states that based on World malaria report, world cases of malaria reached 216 million and an estimated of 655 thousand people died, in 2010. Overproduction of pro-inflammatory cytokines by phagocytic cells and activated endothelial cells occurs In the severe malaria. Bangle (Zingiber cassumunar Roxb.) has the potential to be developed as a new complementary therapy that is expected to prevent fatal malaria complications. The research objective is to test in vivo, the activity of a compound of standardized Bangle (Zingiber cassumunar Roxb.) fraction extract as a complementary therapy along with standard anti-malarial drug, artemisin. This is a true experimental study using twenty-five mice Balb / C male which are divided into five groups; the negative control group, positive control group treated KI, II, and III stimulation with each of the compounds of standardized fraction extract of bangle ( FEBT-h, FEBT-dcm, FEBT-m) for 14 days. Oneway ANOVA test showed the result of p = 0.01 (p <0.05). Continued with LSD test that showed the most significant in lowering the degree of parasitaemia is the group of methanol (FEBT-m).Keywords: Zingiber cassumunar Roxb, fractionated extracts, complementary therapies, malaria
Kadar IL-10 Mencit Balb/C Terinfeksi Plasmodium berghei dengan Pemberian Fraksi Metanol Bangle (Zingiber cassumunar Roxb.) sebagai Terapi Komplementer (The IL-10 level of Plasmodium berghei-infected Balb/C Mice after Methanolic Fraction of Bangle (Zingib Asis Fitriana; Bagus Hermansyah; Muhammad Afiful Jauhani; Wiwien Sugih Utami
Pustaka Kesehatan Vol 6 No 1 (2018)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v6i1.6791

Abstract

Malaria is an infectious disease caused by Plasmodium spp. The cause of mortality in malaria is the parasite’s resistance to malaria drugs and immune system problem. Interleukin-10 is an anti-inflammatory cytokine during plasmodium infection. Bangle is a herbal remedy that contains high amount of curcumin showing immunostimulant activity. The purpose of this study was to determine the difference of IL-10 level in Plasmodium berghei-infected Balb/C mice given with methanolic fraction of bangle (Zingiber cassumunar Roxb.) as a complementary therapy. This study was a true experimental with posttest control group design using 25 mice Balb/c which divided into 5 groups (A, B, C, D and E). All groups except group A were infected with P. berghei. After positively infected, group B was not treated, C was treated with artemisinin, group D was given with artemisinin and methanolic fraction bangle 0,017 mg/gBW, group E was treated with methanolic fraction bangle 0,017 mg/gBW. The result showed that group D had the highest-level of IL-10 among the treatment groups. The Post Hoc LSD test showed p value ≥ 0,05. In conclusion, there was no significant difference of IL-10 serum level in P. berghei-infected Balb/C mice given with methanolic fraction of bangle (Z. cassumunar Roxb.) as complementary therapy. Keywords: Interleukin-10, Plasmodium berghei, Bangle (Zingiber cassumunar Roxb.)
Pengaruh Ekstrak Bangle (Zingiber cassumunar Roxb.) terhadap Kadar TNF-ɑ pada Mencit yang Diinfeksi Plasmodium berghei Pungky Setya Arini; Wiwien Sugih Utami; Erma Sulistyaningsih
Pustaka Kesehatan Vol 2 No 2 (2014)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Malaria is an infectious disease caused by Plasmodium spp. Death in malaria is resulting from the parasite’s resistance to malaria drugs and immune system problem. This study was conducted to determine the immunostimulant activity of bangle extract (Zingiber cassumunar Roxb.) in mice infected with Plasmodium berghei. Mice were divided into 5 groups; negative control group [K(-)], positive control group [K(+)] and 3 treatment groups (P1, P2, P3). All groups except K(-) were infected with P. berghei, P1 was treated with Bangle ethanolic extract 0,904 mg/gBW, P2 was given with Bangle ethanolic extract 0,904 mg/gBW and artemisinin 0,0364 mg/gBW, P3 was treated with artemisinin 0,0364 mg/gBW. After 4 days treatment, blood TNF-α from intracardial was measured. The result showed that TNF-α of P1, P2, P3, K(+) and K(-) were 77,46 ± 33,96 ρg/ml, 55,08 ± 15,19 ρg/ml, 85,56 ± 22,43 ρg/ml, 102,81 ± 61,76 ρg/ml, 41,29 ± 2,28 ρg/ml, respectively. The Mann-Whitney test showed p value ≥ 0,05. In conclusion, Zingiber cassumunar Roxb. extract had no effect on TNF-α of P. berghei-infected mice. Keywords: immunostimulant, Zingiber cassumunar Roxb, TNF-α
Peranan Ekstrak Bangle (Zingiber cassumunar Roxb.) terhadap Produksi Nitric Oxide dan Malondialdehyde pada Mencit yang Diinfeksi Plasmodium berghei Devita Prima Nurmasari; Wiwien Sugih Utami; Erma Sulistyaningsih
Pustaka Kesehatan Vol 2 No 3 (2014)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Isolasi rimpang Bangle menunjukkan bahwa terdapat kandungan bioaktif yaitu kurkumin dalam rimpang Bangle. Penelitian ini bertujuan untuk mengetahui peran ekstrak Bangle terhadap produksi Nitric Oxide dan Malondialdehyde pada mencit yang diinfeksi Plasmodium berghei. Jenis dari penelitian ini adalah quasy experimental, dengan post test only control group design. Sebanyak 30 ekor mencit dibagi ke dalam 5 kelompok, masing-masing terdiri dari 6 mencit. Pemberian ekstak Bangle diberikan selama 14 hari dengan tujuan sebagai imunostimulan. Kontrol negatif diberikan aquadest, kontrol positif diinfeksi dengan Plasmodium berghei. Kelompok perlakuan1(P1) distimulasi Bangle. Kelompok perlakuan2(P2) distimulasi Bangle diterapi Artemisinin sedangkan kelompok perlakuan3(P3) diterapi Artemisinin. Terapi diberikan selama 4 hari apabila Plasmodium telah ditemukan dalam darah. Data hasil penelitian ini menunjukkan bahwa terdapat perbedaan yang bermakna antara produksi NO serum P1 dan P2 dengan kontrol positif. Sedangkan produksi MDA serum tidak menunjukkan adanya perbedaan yang bermakna antarkelompok, sehingga dapat disimpulkan bahwa pemberian ekstrak Bangle mampu meningkatkan produksi NO serum namun tidak berperan terhadap produksi MDA serum.   Kata kunci: Bangle, imunostimulan, Nitric Oxide, Malondialdehyde, Plasmodium berghei
Faktor-faktor yang Berhubungan dengan Higienitas Pasien Skabies di Puskesmas Panti Tahun 2014 (Factors Related to Hygiene of Scabies Patients in Panti Primary Health Care 2014) Ika Sriwinarti; Wiwien Sugih Utami; Ida Srisurani Wiji Astuti
Pustaka Kesehatan Vol 3 No 3 (2015)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Scabies is one of the health problems in developing countries and developed countries. Scabies is easier to invest in people who have poor personal hygiene. Risk factors that may affect the hygiene of scabies consist of internal and eksternal factors. The purpose of this study was to analyze the factors which affect the hygiene of scabies patients. This study was a quantitative research with cross sectional approach. Sample was obtained by quota sampling from patients who visited Panti primary health care in 2014. The factors studied were age, gender, education, occupation, marital status and residence. Data analysis was performed by chi square test and logistic regression. Chi square test found significant factors related to the hygiene were age (p=0,002), education (p=0.015), occupation (p=0,029), marital status (p=0,029) and residence (p=0.015) while other factors did not significant. Results of logistic regression test for age p=0.019 OR=0.000, education p=0.045 OR=4.327, occupation p=1,000 OR=0,000, marital status p=0,999 OR=0,000 and residence p=1,000 OR=2,989. Based on this study, it can be concluded that education was the most affecting factor correlated to hygiene of scabies patients. Keywords: hygiene, scabies, Panti primary health care
Association between Personal Hygiene and Incidence of Soil-Transmitted Helminthiasis among Workers at Widodaren Plantation in Jember Regency Zulaikha Rizqina Rahmawati; Bagus Hermansyah; Erfan Efendi; Yunita Armiyanti; Yudha Nurdian; Wiwien Sugih Utami
Journal of Agromedicine and Medical Sciences Vol 6 No 1 (2020)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v6i1.9593

Abstract

Soil-Transmitted Helmithiasis is an infection caused by intestinal nematode worms which in the process of transmission requires soil as media to fullfil its life cycle from non-infective forms to infective forms. The number of infections is influenced by personal hygiene. Personal hygiene consists of the habit of washing hands, cutting nails, eating, defecating and ownership of latrines, and the use of personal protective equipment. This study used a cross sectional research design conducted at Widodaren Plantation with 68 people of samples. Stool examination was determined by kato-katz method, sedimentation, and floatation to detect the presence of Soil-Transmitted Helminth (STH) eggs, while personal hygiene was assessed using questionnaires. Questionnaire and stool examination datas were processed using SPSS data analysis with chi-square method. The results of this study found 26 respondents who were positive for soil-trasmitted helminthiasis infection. The most frequent worm species obtained in this study were Ascaris lumbricoides (57.7%), followed by multiple infections between Hookworm and A. lumbricoides (21.3%), and Hookworm (19.2%). In the chi-square analysis the results were significant between personal hygiene and soil-transmitted helminthiasis with p value of 0,000 (p <0.05). So, it can be concluded that a bad personal hygiene factor has a significant relationship to the incidence of Soil-Transmitted Helminthiasis at Widodaren Plantation. Keywords: Personal hygiene, STH, plantation
Bioactivity of a Compound of Standardized Bangle (Zingiber cassumunar Roxb.) Extract Fraction as a Complimentary Therapy to Prevent Malaria Complications Bagus Hermansyah; Wiwien Sugih Utami
Journal of Agromedicine and Medical Sciences Vol 1 No 2 (2015)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Malaria is still a major problem in the international and national scale. World Health Organization (WHO) states that based on World malaria report, world cases of malaria reached 216 million and an estimated of 655 thousand people died, in 2010. Overproduction of pro-inflammatory cytokines by phagocytic cells and activated endothelial cells occurs In the severe malaria. Bangle (Zingiber cassumunar Roxb.) has the potential to be developed as a new complementary therapy that is expected to prevent fatal malaria complications. The research objective is to test in vivo, the activity of a compound of standardized Bangle (Zingiber cassumunar Roxb.) fraction extract as a complementary therapy along with standard anti-malarial drug, artemisin. This is a true experimental study using twenty-five mice Balb / C male which are divided into five groups; the negative control group, positive control group treated KI, II, and III stimulation with each of the compounds of standardized fraction extract of bangle ( FEBT-h, FEBT-dcm, FEBT-m) for 14 days. Oneway ANOVA test showed the result of p = 0.01 (p <0.05). Continued with LSD test that showed the most significant in lowering the degree of parasitaemia is the group of methanol (FEBT-m).Keywords: Zingiber cassumunar Roxb, fractionated extracts, complementary therapies, malaria
Histopathological Changes in the Wistar Rats Liver Treated with Bangle (Zingiber cassumunar Roxb.) Rhizome Ethanol Extract during Acute Toxicity Test Kesy Sasta Handani; Wiwien Sugih Utami; Bagus Hermansyah; Rena Normasari
Journal of Agromedicine and Medical Sciences Vol 4 No 1 (2018)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v4i1.6327

Abstract

Malaria is still an infectious disease that can not be eradicated. The presence of antimalarial drug resistance case encourages the research on herbal plants that are expected to be a complementary therapy drug of malaria, one of them is bangle (Zingiber cassumunar Roxb.). This research aimed to investigate the effect of bangle (Zingiber cassumunar Roxb.) rhizome ethanol extract to the histopathological changes of Wistar rats liver during acute toxicity test. This research type was true experimental laboratories with posttest only control group design using four treatment groups (given dose 42,609 mg/200gBW + Tween 1%, 213,045 mg/200gBW + Tween 1%, 426,09 mg/200gBW + Tween 1%, and 852.18 mg/200gBW + Tween 1%) and one control group (given 1% Tween). Each treatment groups consisted of five male rats and five female rats. The final mean score of hepatocyte damage as the research data was analyzed by One-Way ANOVA test and showed that p=0,084. It indicated that there was no significant difference of liver histopathology results between groups. Keywords: malaria, bangle rhizome, acute toxicity test, liver histopathology
Pembinaan dan Pengelolaan Faktor Risiko Melalui Penyuluhan Kesehatan Calon Jemaah Haji Kabupaten Jember Ika Rahmawati Sutejo; Nur Hasyimiyyah; Wiwien Sugih Utami; Baskoro Adi Prayitno
J-Dinamika : Jurnal Pengabdian Masyarakat Vol 5 No 2 (2020): Desember
Publisher : Politeknik Negeri Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25047/j-dinamika.v5i2.1431

Abstract

Jumlah jemaah haji Indonesia mengalami peningkatan beberapa tahun terakhir, meski disertai pertambahan jumlah tenaga kesehatan, namun tidak sebanding dengan pelayanan kesehatan yang mereka butuhkan. Oleh karena itu, kegiatan pembinaan, pelayanan, dan perlindungan kesehatan jemaah haji tidak hanya dilaksanakan saat mereka di tanah suci, namun harus dimulai sejak awal saat jemaah haji masih di tanah air. Jumlah calon jemaah haji kabupaten Jember tahun 2018 sebanyak 1.981 orang. Separuh dari jumlah jemaah haji kabupaten Jember adalah lansia yang berusia lebih dari 60 tahun dengan kategori berisiko tinggi. Salah satu Kelompok Bimbingan Haji (KBIH) yang memiliki calon jemaah haji terbanyak di Jember adalah KBIH Al Ghazalie dengan jumlah jemaah 303 orang. Kegiatan pengabdian ini dilakukan melalui penyuluhan kesehatan dan pengumpulan data karakteristik jemaah. Target kegiatan pengabdian ini adalah calon jemaah haji KBIH Al Ghazaalie Jember. Luaran kegiatan ini selain meningkatkan pengetahuan dan kemandirian calon jemaah haji di bidang kesehatan, juga bertujuan mengungkap data karakteristik jemaah yang meliputi distribusi jenis kelamin, kelompok usia, dan jenis penyakit yang banyak diderita. Data ini menggambarkan kondisi riil kesehatan jemaah di lapangan, sehingga diharapkan menjadi fokus perhatian dalam pencegahan dan penanganan penyakit oleh tenaga kesehatan haji Indonesia. Penyuluhan kesehatan berisi materi mengenai penyakit-penyakit yang sering menyerang jemaah haji, status risiko kesehatan, penanganan pertama pada gangguan kesehatan jemaah haji, dan obat-obatan darurat yang disiapkan masing-masing jemaah haji. Karakteristik jemaah haji KBIH Al-Ghazaalie didominasi jemaah laki-laki, berusia 51-60 tahun, dengan penyakit terbanyak yaitu penyakit kardiovaskuler (hipertensi), diabetes melitus dan penyakit respirasi.
Bacterial and parasitic contamination of raw vegetable in Jember regency, Indonesia : potential risk for food-borne diseases Diana Chusna Mufida; Elvia Rahmi Marga Putri; Dini Agustina; Enny Suswati; Muhammad Ali Shodikin; Yunita Armiyanti; Bagus Hermansyah; Wiwien Sugih Utami; Angga Mardro Raharjo
International Journal of Public Health Science (IJPHS) Vol 11, No 4: December 2022
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v11i4.21875

Abstract

A raw vegetable is one of the transmission factors in human food-borne infection. Contamination might start from the plantation, distribution, until at serving time in the dining table. A higher level of contamination will increase the risk of food-borne illness. The study aims to determine bacteria and parasite contamination in some raw vegetables that people usually consume in Jember Regency, East Java, Indonesia. In this study, we collected raw vegetable from eight traditional markets. We chose randomly at each market five samples of vegetables that usually directly consumed, like lettuce, tomato, cabbage, basil, long bean, and cucumber. Pathogens we identified limited on bacteria and parasite like helminth and protozoan group. This study showed that 91% contaminated by E. coli, 84% by Staphylococcus aureus, and 79% contaminated by Vibrio cholerae. Besides bacteria, 36% of samples contaminated by the helminth group, and protozoa contaminated 27%. The most vegetables contaminated was lettuce, even in bacterial or parasitic contamination. This study concluded that there is contamination in raw vegetables usually directly consumed in Jember Regency. It will be a potential risk factor for food-borne illness in the future.
Co-Authors Achmad Ilham Tohari Achmad Maududie Achmad Nazalal Furqon Adella Bintang Saputri Adinda Putri Yusri Amrina Adinda Putri Yusri Amrina Angga Mardro Raharjo Angga Mardro Raharjo Anita Dewi Prahastuti Sujoso, Anita Dewi Prahastuti Ardyansyah, Rizky Robeth Arina, Yuliana Mahdiyah Daat Aris Prasetyo Asis Fitriana Aulya Rahmi Ayundasari, Asti Ayundasari, Asti Azham Purwandhono Aziz, Ayu Munawaroh Bagus Hermansyah Bagus Hermansyah Bagus Hermansyah Bagus Hermansyah Bagus Hermansyah Bambang Ilamto Baskoro Adi Prayitno Brillian Adexa Yudinda Cholis Abrori, Cholis Devita Prima Nurmasari Dewi Rokhmah Dian Eka Putri Harnandhari Diana Chusna Mufida Dicky Setiawan Dini Agustina Dita Diana Parti Drajad, Rahadinda Mutia Dhamar Dwi Prijatmoko Dwita Aryadina Rachmawati Elvia Rahmi Marga Putri ENNY SUSWATI Epafroditus Sanjaya Adiguna Erfan Efendi Erma Sulistyaningsih Erma Sulistyaningsih Faizatun Nikmah, Faizatun Febrianti, Zahrah Ghaiska Najma Amnur Hanu Neda Septian Heni Fatmawati Hermansyah, Bagus Ida Srisurani Wiji Astuti Ika Barokah Suryaningsih Ika Rahmawati Sutejo Ika Rahmawati Sutejo Ika Sriwinarti Irawan Fajar Kusuma Isa Ma'rufi Isa Ma’rufi Jauhani, M. Afiful Jauhar Firdaus Kesy Sasta Handani Khoiruddin, Mukhammad Arif Hadi Kristianningrum Dian Sofiana Laily Nurhayati Laksmi Indreswari Laksmi Indreswari Laksmi Indreswari Leersia Yusi Ratnawati M. Ali Shodikin M.S. Irham Rozaq Mash’ab Zirrun Al-Qomah Mauliya Sri Sukmawati Wahyudi Mei Syafriadi Muhammad Afiful Jauhani Muhammad Afiful Jauhani Muhammad Afiful Jauhani Muhammad Zainul Fikri Mukhammad Arif Hadi Khoirudin Nanda Nuramna Nanik Kurniati Nanik Kurniyati Nidia Nursafitri Nindya Shinta Rumastika Nur Hasyimiyyah Nuri Nurmaida, Eny Nurmaida, Eny Nurus Saffana Yulianto Pangestu, Ahmad Yudho Hadi Pradana, Tasya Lukita Cyndi Pralampita, Pulong Wijang Prriantono, Dwinda Pungky Setya Arini Putra, Muhamad Dwi Eka Rachmawati, Dwita Aryadina Rahardjo, Angga Mardro Ramadanti, Novi Awalia Ramadhani, Rafindra Ratnawati, Leersia Yusi Rena Normasari Rifaldy Nabiel Erisadana Rini Riyanti Rondhianto Rondhianto Sa'bani, Begawan Salsabilla, Safira Putri Nur Selly Silfana Liensa Sugeng Winarso Sulistyaningsih, Erma Syamsuddin, Alif Fazduani Tartila, Jasmine Verdian Rahardi Widjaja Putra, Bayu Taruna Winda Cindy Wulandari Yehuda Tri Nugroho Supranoto Yoga Setyo Yudha Nurdian Yudi Wicaksono Yunita Armianti Yunita Armiyanti Yunita Armiyanti Zulaikha Rizqina Rahmawati