Article Per Year (5 Year)
p-Index From 2021 - 2026
0.444
P-Index
This Author published in this journals
All Journal Essential: Essence of Scientific Medical Journal Indonesian Journal of Pharmacology and Therapy
Ni Made Ersi Dwitami Barsua
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
EFEKTIVITAS FORMULASI EUGENOL EKSTRAK DAUN KAYU MANIS (CINNAMOMUM VERUM) DALAM SEDIAAN NASAL SPRAY PADA PNEUMONIA BAKTERIAL I Wayan Cahya Mahastya; Ni Putu Eka Frastika Sari; Ni Made Ersi Dwitami Barsua
Essence of Scientific Medical Journal Vol 20 No 2 (2022): Volume 20 No. 2 (Juli - Desember 2022) Essential: Essence of Scientific Medical
Publisher : Kelompok Ilmiah Hippocrates Fakultas Kedokteran Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/essential.v20i2.92945

Abstract

Pendahuluan: Pneumonia merupakan penyakit infeksi bakteri, virus, maupun jamur pada saluran pernafasan yang menyerang alveolus. Penanganan antibiotik pneumonia sering kali menyebabkan terjadinya suatu resistensi sehingga disperlukan suatu modalitas baru yang bisa menjadi alternatif antibiotik sekaligus antiinflamasi. Terdapat suatu senyawa eugenol pada daun kayu manis (Cinnamomum verum) yang memiliki spesifitas tersebut. Pembahasan: Pada pneumonia, antibakteri pada eugenol akan terjadi karena mekanisme pada membran sel bakteri dan menimbulkan sitotoksisitas pada DNA bakteri penyebab pneumonia. Sedangkan, sebagai antiinflamasi, eugenol akan berpengaruh terhadap migrasi leukosit, polimorfonuklear (PMN), dan makrofag. Penggunaan nasal spray dapat dijadikan pilihan alternatif yang baik dalam memberikan ekstrak eugenol pada pastien pneumonia karena mukosa nasal yang penuh dengan pembuluh darah memiliki daya absorbsi yang sangat baik. Simpulan: Dengan demikian, efek antiinflamasi yang terdapat pada eugenol dapat mencapai siklus sistemik dan efek antibakteri mampu meminimalisasi bakteri penyebab pneumonia di sekitar sistem pernapasan. Kata kunci: Cinnamomum verum, Eugenol, Nasal spray, dan Pneumonia
The potency of kitolod leaves (Hipobroma longiflora) as traditional medicine for conjunctivitis during the COVID-19 pandemic: a brief review Yuliana; Ni Made Ersi Dwitami Barsua; Made Wulan Virgioni Putri; I Nyoman Satya Mahayana Putra
Indonesian Journal of Pharmacology and Therapy Vol 4 No 2 (2023)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.7542

Abstract

During the coronavirus disease 2019 (COVID-19) pandemic, most activities have transformed into digital ones, including computer usage. The digital screen on the computer has blue light radiation which can activate inflammatory cytokines of the eye surface and cause various disorders including includes conjunctivitis. Kitolod leaves (Hippobroma longiflora) have been used traditionally to treat conjunctivitis. This paper aimed to describe the potency of kitolod leaves for conjunctivitis. This is a narrative literature review using publications gathering from PubMed and Google Scholar published since 2013 with exclusion criteria were the animal studies. The keywords of COVID-19 pandemic, blue light, conjunctivitis, H. longiflora, traditional therapy were used. Boolean logic "AND" was used to find specific international scientific publications in PubMed. Forty selected publications were gathered, summarized and then narrated. The kitolod leaves contains bioactive substances i.e. flavonoids, alkaloids, and saponins which can inhibit S. aureus growth as the main cause of conjunctivitis. The mechanism of antibacterial of these bioactive substances through inhibition of nucleic acid synthesis, disruption of cytoplasmic membrane function, and inhibition of energy formation process. Kitolod leaves is potential to develop as traditional medicine for conjunctivitis. However, further studies are required to obtain the best standardized extract and to evaluate its clinical efficacy and safety.
Co-Authors I Nyoman Satya Mahayana Putra I Wayan Cahya Mahastya Made Wulan Virgioni Putri Ni Putu Eka Frastika Sari Yuliana Yuliana