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Perbandingan indeks massa tubuh, lingkar pinggang, dan rasio pinggang pinggul sebagai faktor risiko kanker kolorektal Khosama, Yuansun; Sapan, Heber B.; Panelewen, Jimmy; Kalesaran, Laurens T. B.
Jurnal Biomedik : JBM Vol 8, No 2 (2016): JURNAL BIOMEDIK : JBM
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.8.2.2016.12670

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Abstract: Globally, colorectal cancer is the 4th cause of deaths. Risk factors of colorectal cancer are divided into modified and unmodified; obesity is one of the modified factors. It is accepted that insulin resistance and metabolic dysfunction act as a link between obesity and colorectal cancer. Distribution of fat tissue in Asian including Indonesian differs from that in Western people. Although of the same body mass index (BMI), Asian have higher fat tissue level than the Westerns. Body fat tissue can be measured by using BMI, waist circumference (WC), and waist-hip ratio (WHR). Acurate anthropometric measurements play some important roles in prevention of colorectal cancer. This study aimed to compare the three anthropometric parameters in colorectal cancer patients. This was a descriptive analytical study with a cross sectional design. Subjects were colorectal patients admitted to Surgery Department of Sam Ratulangi University Manado and its collaborationg hospitals from June 2015 to December 2015. There were 33 colorectal cancer patients in this study consisted of 22 males and 11 females. The ages ranged from 27 years to 77 years. The sensitivity result was as follows: BMI 33.3%, WC 51%, and WHR 42%, meanwhile the specifity result was 75.80%; 60.60%; and 60.60% respectively. The X2 test showed a P value of 0.327. Conclusion: Statistically, BMI, WC, and WHR showed no significant difference as the risk factors of colorectal cancer. However, the three parameters have to be used together to detect the accumulation of body fat tissue. It is suggested that the detection has to be applied in primary health care to diminish the colorectal cancer risk.Keywords: colorectal cancer, BMI, WC, WHRAbstrak: Kanker kolorektal (KKR) merupakan penyebab kematian keempat terbanyak di dunia. Secara garis besar faktor risiko KKR terbagi atas yang tidak dapat dimodifikasi dan yang dapat dimodifikasi, salah satunya ialah obesitas. Resistensi insulin dan disfungsi metabolik menjadi penghubung antara obesitas dan karsinoma kolorektal. Distribusi lemak tubuh pada orang Asia, termasuk Indonesia, berbeda dengan distribusi lemak tubuh pada orang Barat. Pada indeks massa tubuh (IMT) yang sama, orang Asia memiliki kadar lemak tubuh yang lebih tinggi dibandingkan orang Barat. Kadar lemak tubuh dapat dinilai melalui pengukuran IMT, lingkar pinggang (LP), dan rasio pinggang-pinggul (RPP). Penelitian ini bertujuan untuk membandingkan ketiga parameter ukuran antropometri tubuh pada pasien KKR. Penentuan patokan antropometri tubuh yang tepat membantu tindakan preventif KKR. Jenis penelitian ialah deskriptif analitik dengan desain potong lintang. Subyek penelitian ialah pasien KKR yang dirawat di Bagian Bedah Fakultas Kedokteran Universitas Sam Ratulangi Manado dan RS jejaringnya sejak bulan Juni 2015-Desember 2015. Hasil penelitian mendapatkan 33 pasien KKR (22 laki-laki dan 11 perempuan). Usia pasien berkisar 27-77 tahun. Sensitivitas IMT ialah 33,3%; LP 51%; dan RPP 42%, sedangkan spesifisitas berturut-turut ialah 75,80%; 60,60%; dan 60,60%. Uji X2 mendapatkan nilai P = 0,327. Simpulan: IMT, LP, dan RPP secara statistik tidak menunjukkan perbedaan bermakna sebagai faktor risiko KKR. Ketiganya harus diukur bersama-sama untuk mendeteksi akumulasi lemak tubuh. Disarankan deteksi harus dimulai di pelayanan primer untuk mengurangi risiko KKR.Kata kunci: KKR, IMT, LP, RPP
Faktor Risiko Kanker Kolorektal Khosama, Yuansun
Cermin Dunia Kedokteran Vol 42, No 11 (2015): Kanker
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (147.93 KB) | DOI: 10.55175/cdk.v42i11.945

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Insiden kanker kolorektal (KKR) meningkat dalam beberapa dekade terakhir. Kasus KKR pada populasi Asia sulit dideteksi dini karena bentuk lesi non-polipoid dan sering tidak didahului adenoma. KKR dipicu oleh berbagai faktor risiko baik yang dapat dimodifikasi dan tidak dapat dimodifikasi. Gaya hidup dan pola diet termasuk faktor risiko yang dapat dimodifikasi. Pemahaman yang tepat mengenai faktor risiko dapat membantu tenaga medis memberi edukasi kepada masyarakat agar dapat mengurangi insiden KKR.The incidence of colorectal cancer is increasing in the last several decades. Colorectal cancer in Asian population is difficult to be detected due to non-polypoid lesion as opposed to adenoma. There are several risk factors for colorectal cancer, both modifiable and non-modifiable. Diet and lifestyle are two modifiable risk factors. Accurate understanding of risk factors can help healthcare workers to reduce colorectal cancer incidence through public education.
Endovascular Fistula Salvage for Preserving Arteriovenous Fistula Failure in Haemodialysis Patient: Tertiary Referral Hospital, a Single-Centre Experience Karundeng, Billy; Sumangkut, Richard; Tjandra, Djony; Khosama, Yuansun; Juliandi, Tomi
e-CliniC Vol. 12 No. 2 (2024): e-CliniC
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.v12i2.46644

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Abstract: Efficacy of endovascular intervention for the preservation of failing accesses is very important in hemodialysis patients. This study aimed to determine the efficacy of endovascular balloon angioplasty in preserving the patency of hemodialysis arteriovenous fistula (AVF) failure. This was a retrospective study of hemodialysis patients who received endovascular intervention due to access difficulties. A single-center study was created between January 2022 and June 2022. Fistulography was conducted on patients suspected of having access stenosis, and balloon angioplasty was performed in the same setting if stenosis of 50% was confirmed. Post-operative complications and access restenosis or failure were monitored. The results obtained 69 patients with hemodialysis access failure due to AVF stenosis, occlusion, and thrombosis that were admitted or referred to our hospital. The majority of patients were 40-60 years (50.7%); 88.4% patients were male and 11.6% were female, with a mean age of 56.3±11.6 (range, 18–77). The sites of AVF failure were brachiocephalic (81.1%) and radiocephalic (18.9%). There was no complication recorded. The procedure succes rate was 81.1%. In conclusion, endovascular balloon angioplasty is effective in restoring hemodialysis access patency. Recurrence is common, and interventions must be repeated. Keeping access open can save lives. Percutaneous transluminal angioplasty (PTA) can be used to achieve safely and successfully repair arteriovenous fistulas failure. Keywords: angioplasty; arteriovenous fistula; arteriovenous graft; hemodialysis
Assessing The Significance Of The Wifi Score In Determining Clinical Progression And Amputation Risk In Patients With Chronic Limb-Threatening Ischemia And Type 2 Diabetes Mellitus Winar, Michael Dian; Khosama, Yuansun; Billy Karundeng
International Journal of Social Service and Research Vol. 5 No. 10 (2025): International Journal of Social Service and Research
Publisher : Ridwan Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/ijssr.v5i10.1335

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Chronic Limb Threatening Ischemia (CLTI) represents the most severe stage of peripheral arterial disease, often compounded by comorbid type 2 diabetes mellitus (DMT2), which exacerbates wound healing impairment and increases amputation risk. The Wound, Ischemia, and foot Infection (WIFI) score offers a structured approach to assess limb severity and guide clinical decision-making. Objective: This study aims to evaluate the clinical significance of the WIFI score in predicting disease progression and major amputation risk among CLTI patients with DMT2 Methods: A retrospective cohort analysis was conducted on patients diagnosed with CLTI and DMT2. Clinical outcomes—including mortality and major amputation—were correlated with WIFI staging using Cox regression analysis. Results: Higher initial WIFI scores were significantly associated with increased rates of major amputation (41.7%) and mortality (29.2%) in the high-risk group, compared to 0% in the low-risk group. Patients who underwent angioplasty showed a mean reduction of 2.8 points in WIFI score, correlating with improved outcomes. Cox regression revealed that each 1-point increase in WIFI score was associated with a 1.9-fold increase in amputation risk and a 2.1-fold increase in mortality. Conclusion: The WIFI score is a clinically meaningful tool for predicting outcomes and guiding management in CLTI patients with DMT2. Its integration into routine vascular assessment enhances risk stratification, supports revascularization decisions, and may reduce unnecessary amputations—especially in resource-limited settings.
Hubungan antara Plantar Acceleration Time dengan Ankle Brachial Index sebagai Alternatif Pemeriksaan dalam Mendiagnosis Chronic Limb Threatening Ischemia pada Pasien Diabetes Melitus Natanael Adam, Rizky; Khosama, Yuansun; Karundeng, Billy; Langi, Fima L.F.G.
Jurnal sosial dan sains Vol. 4 No. 10 (2024): Jurnal Sosial dan Sains
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/jurnalsosains.v4i10.20026

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Latar Belakang: Chronic Limb Threatening Ischemia (CLTI) merupakan tahap lanjut dari Penyakit Arteri Perifer (PAD), yang sering kali diperburuk pada pasien Diabetes Melitus (DM). Diagnosis dini menjadi tantangan, terutama karena keterbatasan metode standar seperti Ankle Brachial Index (ABI), terutama pada pasien DM dengan pembuluh darah yang kaku. Oleh karena itu, diperlukan alternatif metode pemeriksaan seperti Plantar Acceleration Time (PAT). Tujuan: Penelitian ini bertujuan untuk meneliti hubungan antara PAT dan ABI sebagai metode alternatif dalam mendiagnosis CLTI pada pasien DM. Metode: Penelitian ini menggunakan desain observasional cross-sectional dengan 50 pasien DM yang menjalani pemeriksaan ABI dan PAT di RSUP Prof. Dr. R. D. Kandou Manado. Data demografik dan klinis pasien dianalisis menggunakan uji statistik deskriptif dan regresi linear untuk menilai hubungan antara PAT dan ABI. Hasil: Hasil penelitian menunjukkan bahwa terdapat hubungan signifikan antara PAT dan ABI. Nilai PAT lebih tinggi pada pasien dengan ABI abnormal, mengindikasikan adanya peningkatan resistensi aliran darah pada pasien CLTI. Kesimpulan: PAT dapat menjadi metode tambahan yang berguna untuk mendiagnosis CLTI, khususnya pada pasien DM yang memiliki keterbatasan dalam penggunaan ABI. Kombinasi PAT dan ABI dapat meningkatkan akurasi diagnosis CLTI dan membantu dalam perencanaan terapi yang lebih tepat.