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All Journal Jurnal Ilmiah Kedokteran Wijaya Kusuma Calvaria Medical Journal
Elizabeth Haryanti
Bagian Ilmu Penyakit Dalam Fakultas Kedokteran Universitas Wijaya Kusuma Surabaya
Biochemistry, Genetics & Molecular Biology Education Immunology & microbiology Medicine & Pharmacology Public Health

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Pengaruh Spirulina terhadap VEGF dari Trofoblast Tikus Putih Hamil Strain Wistar yang Diinduksi Interleukin 6 Harry K Gondo; Elizabeth Haryanti
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 9, No 2 (2020): SEPTEMBER 2020
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (777.206 KB) | DOI: 10.30742/jikw.v9i2.750

Abstract

Preeclampsia is a pregnancy disorder with hypertension as one of its common symptoms. Preeclampsia in pregnancy is characterized by increasing of proteinuria, blood pressure and also interleukin 6. Spirulina sp is a thread like shaped blue-green algae, similar to chain of cylindrical cells with 1 to 12 μm diameter of cell membrane. The purpose of this research was to know the effect of spirulina on VEGF level in improving of trophoblast function in pregnant white Rats Wistar. The design of the study was laboratory experimental with post-test only control group design. Twenty-five rats with preeclampsia model induced by interleukin 6, were divided into 5 groups. The groups were control group, positive control group (P0) injected by interleukin-6 dose of 5 ng/ 100 gram body weight (BW), group with spirulina dose of 10 mg/100 gram BW (P1), group with spirulina dose of 20 mg/100 gram BW (P2); and group with spirulina dosage 40 mg/100 gram BW (P3). The Vascular endothelial growth factor (VEGF) levels were in experimental groups measured compared to control. The averages of group spirulina were 81.31 (10 mg/100 gram BW), 65.99 (20 mg/100 gram BW), and 49.62 (40 mg/100 gram BW). In comparison with control group (62.70), VEGF level in group administered by spirulina dose of 20 mg/100 gram BW were close to control group.
Induction of interleukin-6 trigger an apoptosis through IL-17 and stat3 pathway that alleviated by phycocyanin treatment Elizabeth Haryanti; Harry K Gondo
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 5, No 2 (2016): Edisi September 2016
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (75.754 KB) | DOI: 10.30742/jikw.v5i2.337

Abstract

This study was to analyze the optimum dose of IL-6 induction in pregnant rats that could trigger an increase in mean arterial pressure and protein as two symptoms of preeclampsia. A total of 25 pregnant rats was divided into 5 groups, including pregnant rats the control group (without induction of IL-6), a group of pregnant rats were given an induction in IL-6 doses of 1.25 ng/day, a group of pregnant rats given doses of IL-6 induction 2.5 ng/day, a group of pregnant rats were given an induction of IL-6 doses of 5 ng/day, and groups of pregnant rats were given an induction in IL-6 doses of 10 ng/day. Induction of IL-6 was performed on the tenth day of gestation for 5 days. The expression of caspase-3, IL-17, and STAT3 were analyzed by confocal laser scanning microscopy. The expression of caspase-3, IL-17 and STAT3 was significantly higher in preeclampsia group than the control group (p<0.05). The expression of caspase-3 decreased significantly in all groups were treated by phycocyanin compared to the preeclamptic group (p<0.05), but has not been able to reach expression comparable to the control group (p<0.05). Expression of IL-17 decreased significantly in the group given the two highest doses of phycocyanin compared to the preeclampsia group (p<0.05). STAT3 expression decreased significantly in all groups were treatedby phycocyanin compared to the preeclamptic group (p<0.05), reached expression comparable to the control group in the group received phycocyanin at doses of 10 and 20 ng (p> 0.05). In conclusion, IL-6 on pregnant rats were able to increase apoptosis through IL-17 and STAT pathway. Inhibition of apoptosis due to phycoyanin treatment not only involve the formation of IL-17, this data is found in phycocyanin doses of 10 and 20 ng.
Hubungan Komorbid Hipertensi Terhadap Kematian Pasien Coronavirus Disease 2019 Melalui Review Literatur Tahun 2019-2022 Herlin Dianing; Ira Idawati; Elizabeth Haryanti
Calvaria Medical Journal Vol 1 No 1 (2023): Edisi Juni 2023
Publisher : Institute for Research and Community Services (LPPM) of University of Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/cmj.v1i1.14

Abstract

Tahun 2019, virus mematikan bernama Coronavirus atau COVID-19 muncul. Virus ini menyebar dengan cepat pada individu dan Indikasi primernya adalah demam, pilek, batuk, sesak napas. Gejala yang ditunjukkan mirip dengan flu. COVID-19 mencapai tingkat pandemi dan mengakibatkan kematian di seluruh Dunia dan penularan dari manusia ke manusia. Penelitian terbaru melaporkan bahwa hipertensi merupakan salah satu komorbid paling umum pada pasien dengan COVID-19. Prevalensi komorbid hipertensi mencapai persentase antara 10% hingga 34%. Adapun dampak komorbid hipertensi pada kematian pasien dengan COVID-19 sangat berpengaruh karena secara tidak langsung pasien dengan komorbid hipertensi akan merusak sistem pembuluh darah secara perlahan. Metode yang dipilih dalam meyusun penelitian ini adalah penelitian kualitatif dengan literature review yang relevan dari berbagai sumber data dari jurnal nasional maupun internasional dan terkhusus pada hubungan komorbid hipertensi terhadap kematian pasien coronavirus disease 2019. Sumber rujukan adalah database Science Direct, Researchgate, PubMed, Journal of Emerging Technologies and Innovative Research (JETIR). Dalam penelitian ini menunjukkan bahwa hipertensi meningkatkan risiko keparahan COVID-19 dan kematian terkait COVID-19, yang selalu dikaitkan dengan usia, obesitas, diabetes mellitus, penyakit kardiovaskular dan serebrovaskular, dan penyakit pernapasan kronis.
Pengaruh Spirulina terhadap Kadar beta hCG Tikus Bunting yang Diinduksi Interleukin-6 (Studi Bahan Biologis Tersimpan) Harry K Gondo; Elizabeth Haryanti
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 10, No 1 (2021): MARET 2021
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v10i1.1067

Abstract

Preeclampsia is multisystem specific disorder in pregnancy. Preeclampsia characterized by increased cytokine Interleukin-6 and β hCG (human Chorionic Gonadotropin). Spirulina is green-blue alga contain antioxidant, vitamin, mineral. Spirulina has a potential effect as antiinflammation. The aim of this research was to know effect of spirulina to repair trophoblast at β hCG level of pregnant rats with preeclampsia condition (biology material collecting). The type of this research is an experimental laboratory with post-test only control group design. Preeclampsia models induced by Interleukin-6. Twenty-five rats were grouped to five group: Control, Control Positive, Spirulina dose 10, 20, and 40 mg/day, at the end of treatment, β hCG level were analyzed. Statistical analysis was used by one-way ANOVA. The results of this study showed that β hCG level of group spirulina dose 10 mg/day (85.11 ± 25.70 mIU/ml) did not significantly different (p=0.353), with group Dose 20 mg/day (79.65 ± 10.65 mIU/ml). Level of β hCG in Spirulina group dose 40 mg/day were 93.28 ± 17.12 mIU/ml. The spirulina groups dose 10 mg/day and dose 40 mg/day did not show significantly different level of β hCG (0.730> 0.05). Administration of spirulina at a dose of 10 mg was able to significantly reduce levels of β hCG (P <0.05) than at doses of 20 mg / day and 40 mg/ day.
Co-Authors Harry K Gondo Harry K Gondo Herlin Dianing Ira Idawati