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All Journal The Journal of Experimental Life Sciences (JELS) BIOEDUSAINS: Jurnal Pendidikan Biologi dan Sains
Herlina Pratiwi
Universitas Brawijaya
Biochemistry, Genetics & Molecular Biology Education Immunology & microbiology Medicine & Pharmacology Neuroscience

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Preventive effects of yogurt fortified with purple roselle extract against cardiotoxicity in rats exposed with 2,3,7,8-tetrachlorodibenzo-p-dioxin Ani Setianingrum; Iffa Fanadila; Herlina Pratiwi; Ajeng Erika Prihastuti Haskito
The Journal of Experimental Life Science Vol. 11 No. 3 (2021)
Publisher : Postgraduate School, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jels.2021.011.03.02

Abstract

Dioxin is one of the environmental persistent organic pollutants that harm animal and human health. Prolonged exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) can disrupt normal organ function including heart. Yogurt is known to have antioxidant properties, and fortification natural plant-based antioxidant purple roselle (Hibiscus sabdariffa L) extract into yogurt can improve the antioxidant potential. The purpose of this study was to determine the preventive effect of yogurt fortified with purple roselle on dioxin exposure rats (Rattus norvegicus) based on the levels of Malondialdehyde (MDA) and histopathological of the heart. This experimental study using a completely randomized design (CRD). A total of 30 male Wistar rats were divided into 5 groups (NC, PC, T1, T2, T3), a dose of 200 ng/kg BW TCDD and 1 mL of roselle yogurt 0.5%, 1.0%, and 1.5% were given orally for 12 days. MDA levels were analyzed using the Thiobarbituric Acid (TBA) assay and histopathology of the heart using the Haematoxylin Eosin (HE) staining method. Statistical analysis using one-way Analysis of Variance (ANOVA). Histopathology changes were analyzed descriptively. The results showed that TCDD exposure induced oxidative stress in heart tissue and yogurt roselle has the potential to prevent an increase of MDA levels significantly (p<0.05). Furthermore, TCDD can cause histopathological alterations such as necrosis and hemorrhage, and yogurt roselle was proven to prevent cardiotoxicity due to TCDD exposure.
Peningkatan Pembelajaran Biologi di Sekolah Menengah Atas Melalui Kerjasama Fakultas Kedokteran Hewan Fajar S Permata; Analis W. Wardhana; Herlina Pratiwi; Dyah A.O.A. Pratama; Albiruni Haryo; Galuh C. Agustina; Agung P.W. Marhendra
BIOEDUSAINS:Jurnal Pendidikan Biologi dan Sains Vol 6 No 2 (2023): BIOEDUSAINS:Jurnal Pendidikan Biologi dan Sains
Publisher : Institut Penelitian Matematika, Komputer, Keperawatan, Pendidikan dan Ekonomi (IPM2KPE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31539/bioedusains.v6i2.8034

Abstract

Research aimed to determine the improvement in high school (SMA) biology learning outcomes through collaboration with the Faculty of Veterinary Medicine at Brawijaya University. The chosen methodology is quantitative descriptive. The collaboration commenced with an agreement between the School of Veterinary Medicine and SMAN 8 Malang. Participants included 34 11th-grade students and 3 biology teachers. The event began with an opening ceremony, followed by administering a pretest and distributing worksheets to the participants. The workshop comprised two main steps. Firstly, a seminar on various animal anatomies was conducted by faculty members from the Faculty of Veterinary Medicine, lasting for 100 minutes. Subsequently, practical sessions on bovine osteology and direct examination of animal organs, including mice, chickens, and fish, took place over 180 minutes. These practical sessions were guided by students from the School of Veterinary Medicine serving as assistants in the Anatomy Laboratory. Finally, participants underwent a posttest, completed a questionnaire, and took a group photo. Pretest and posttest scores were evaluated. The research findings indicate that the average pretest score was 25.38±4.73. Following the workshop activities, the average posttest score increased to 51.83±17.22, signifying a 100% improvement in the average posttest scores. Additionally, 18.92% of participants achieved scores exceeding 70. Based on the questionnaire, the majority of participants (55.56%) rated the collaboration activity as excellent. In conclusion, this collaboration significantly enhances biology learning in high schools, providing substantial benefits for both students and teachers. Keywords: Animal Anatomy, Veterinary Medicine, SMAN 8 Malang, Biology Workshop
Co-Authors Agung P.W. Marhendra Ajeng Erika Prihastuti Haskito Albiruni Haryo Analis W. Wardhana Ani Setianingrum Dyah A.O.A. Pratama Fajar S Permata Galuh C. Agustina Iffa Fanadila