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All Journal IJFAC (Indonesian Journal of Fundamental and Applied Chemistry) Majalah Farmaseutik
ZULLIES IKAWATI
Gadjah Mada University
Biochemistry, Genetics & Molecular Biology Chemistry Environmental Science Medicine & Pharmacology

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ASSOCIATION OF DRUG RELATED PROBLEMS (DRPs) OCCURRENCE WITH CLINICAL OUTCOME IN ISCHEMIC STROKE PATIENTS FIRDHA APRILLIA WARDHANI; ZULLIES IKAWATI; NANANG MUNIF YASIN
Majalah Farmaseutik Vol 19, No 1 (2023)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v19i1.74413

Abstract

Ischemic stroke is one of the main causes of death and disability in Indonesia and in the world whose prevalence continues to increase. One of the factors that increase disability in ischemic stroke patients is poor stroke management, and the incidence of DRPs plays a role in it. This study was conducted to determine whether there is a significant relationship between the incidence of DRPs in ischemic stroke patients, and the patient's clinical outcome, which is described by the patient's NIHSS status. It is known that NIHSS is an outcome parameter with the best accuracy and sensitivity compared to other outcome parameters. The study was conducted with a retrospective cross-sectional design, involving 111 samples sourced from the medical records of patients who met the inclusion criteria in the April-October 2021 period. The DRPs analyzed in this study were medication errors, the need for additional drugs, too low drug doses, and drug side effects occur. In this study, DRPs occurred in 88.2% of patients, with the most common type being the need for additional drugs in patients. This study found that the presence of DRPs in ischemic stroke patients, has the potential to increase the risk of patients experiencing clinical outcomes that do not improve as described by the NIHSS status (OR 3,714; p-value<0,05).
Antibacterial and Antibiofilm Activity Testing of Black Betel Leaves (Piper betle L. var. nigra) Ethanol Extract on Staphylococcus aureus and Pseudomonas aeruginosa Using Microdilution Method Tasya Hardina Adha; Zullies Ikawati; Sylvia Utami Tunjung Pratiwi
IJFAC (Indonesian Journal of Fundamental and Applied Chemistry) Vol 10, No 1 (2025): February 2025
Publisher : IJFAC (Indonesian Journal of Fundamental and Applied Chemistry)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24845/ijfac.v10.i1.59

Abstract

The use of antibiotics is key to treating infected wounds. However, its effectiveness has begun to decrease due to the high bacterial resistance, which is caused by the phenomenon of biofilm. Therefore, it’s necessary to discover new antibacterial and antibiofilm activity agents that can be used as alternative therapies. This study aims to test the antibacterial and antibiofilm activity of black betel leaves (Piper betle L. var. nigra) ethanol extract. Antibacterial and antibiofilm activity test was conducted using the microdilution method against Staphylococcus aureus and Pseudomonas aeruginosa with concentration variations 4; 2; 1; 0.5; 0.25; and 0.125 mg/mL, also used positive control kanamycin 10 mg/mL and negative control DMSO 1%. The results showed that the black betel leaves ethanol extract had low antibacterial activity with MIC50 > 4 mg/mL for both bacteria and vigorous antibiofilm activity with MBIC50 < 0.125 mg/mL for S. aureus and MBIC = 0.491 mg/mL for P. aeruginosa. The antibacterial activity of the black betel leaves ethanol extract was lower than it’s antibiofilm activity, the antibacterial and antibiofilm activities of the black betel leaves ethanol extract were higher against S. aureus than P. aeruginosa.Keywords: Antibacterial, Antibiofilm, Piper betle L. var. nigra
Review: Cost-Effectiveness Analysis Angiotensin Converting Enzyme Inhibitor (ACEI) Dibandingkan dengan Angiotensin Receptor Blocker (ARB) pada Hipertensi Safira Khairina; Tri Murti Andayani; Zullies Ikawati
Majalah Farmaseutik Vol 22, No 1 (2026)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v22i1.105904

Abstract

Hipertensi menjadi topik yang paling banyak dipelajari dalam tahun-tahun terakhir. Hipertensi juga menjadi komoditi paling signifikan dalam perkembangan penyakit stroke, infark miokard, gagal jantung, dan gagal ginjal. Golongan Angiotensin Converting Enzyme Inhibitor (ACEI) dengan Angiotensin Receptor Blocker (ARB)  termasuk dalam obat-obat lini utama sesuai dengan pedoman tatalaksana terapi. Review ini bertujuan untuk membandingkan hasil penelitian tentang efektivitas, baik dari segi pengobatan maupun biaya, dalam penggunaan ACEI dan ARB, untuk membantu tenaga kesehatan dalam membuat keputusan dalam pemilihan terapi hipertensi. Review dilakukan dengan studi literatur secara online, menggunakan kata kunci dan strategi dengan PICOS framework, dari berbagai basis data Pubmed, Science Direct dan Scopus. Dalam pencarian terdapat 56 artikel penelitian yang sesuai, dan dilakukan identifikasi menggunakan PRISMA 2020 Flow Diagram. Terdapat 3 (tiga) artikel yang sesuai kriteria akhir, yang kemudan dilakukan penilaian kualitas dengan menggunakan CHEERS Checklist. Dari artikel tersebut penggunaan ARB terbukti lebih efektif jika dibandingkan dengan ramipril, dilihat dari penurunan tekanan datah dan peningkatan kualitas hidup pasien. Review sistematik ini menunjukkan bahwa ARB sebagai terapi antihipertensi terbukti cost effective jika dibandingkan dengan ACEI.
Co-Authors NANANG MUNIF YASIN Safira Khairina Sylvia Utami Tunjung Pratiwi Tasya Hardina Adha Tri Murti Andayani Wardhani, Firdha Aprillia