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All Journal Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Pharmaciana: Jurnal Kefarmasian Al-Kimia Majalah Farmaseutik Pharmacology and Clinical Pharmacy Research Pharmaceutical Journal of Indonesia Jurnal Mandala Pharmacon Indonesia JURNAL FARMASIMED (JFM) Jurnal Ilmiah Farmako Bahari BERNAS: Jurnal Pengabdian Kepada Masyarakat Medfarm: Jurnal Farmasi dan Kesehatan Jurnal Pengabdian UNDIKMA Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang Eureka Herba Indonesia Jurnal Pengabdian Masyarakat Madani Jurnal Pengabdian Masyarakat Journal of Agropharmacy Dirya : Journal of Economic Management Halal Science
Wardhani, Firdha Aprillia
Departement Of Clinical And Community Pharmacy, Faculty Of Pharmacy, University Of Jember
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Kadar Fenolat dan Flavonoid Total serta Kapasitas Antioksidan Ekstrak Etanol dan Fraksi Jahe Merah (Zingiber officinale var. Rubrum) Dwi Koko Pratoko; Firdha Aprillia Wardhani; Nia Kristiningrum; Fifteen Aprila Fajrin; Dian Agung Pangaribowo
Al-Kimia Vol 6 No 2 (2018): December
Publisher : Study Program of Chemistry - Alauddin State Islamic University of Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/al-kimia.v6i2.6316

Abstract

Determination of total phenolic, total flavonoid, and antioxidant capacity of ethanolic extract and fractions from red ginger (Zingiber officinale var. Rubrum) has been done. Red gingers contain the highest oleoresins among other ginger varieties. Oleoresins are component that had the most responsibility for pharmacological effect of red ginger, one of them is as antioxidant. Phenolic and flavonoid are highly contributing to the antioxidant effect of red ginger. The aim of this research is to determine the antioxidant capacity of extract and fractions of red ginger, and to investigate the correlation between antioxidant capacity with both total phenolic and total flavonoid. Ethanolic extracts are fractinationed with n-hexane, chloroform, ethyl acetate, n-butanol, and methanol solvent. Antioxidant capacity, total phenolic, and total flavonoid of all the samples are measured. Highest antioxidant capacity, total phenolic, and total flavonoid obtained from ethyl acetate fraction with TEAC 2143.9 ± 0.9 µmol/g (CUPRAC) and 4526.4 ± 3.0 (DPPH), GAE 229.9 ± 1.3 mg/g, and QE 46,6 ± 1,8 mg/g. One way ANOVA and post hoc analysis show significant result with p value <0,01. Pearson correlation shows high positive correlation. Determination of total phenolic, total flavonoid, antioxidant capacity from ethanolic extract and fractions of red ginger (Zingiber officinale var. Rubrum) has been done.Red ginger contain the highest oleoresins among other ginger varieties. Oleoresins are component that had the most responsibility for pharmacological effect of red ginger, one of them is as antioxidant. Phenolic and flavonoid are highly contribute to the antioxidant effect of red ginger. The aim of this research is to determine the antioxidant capacity of extract and fractions of red ginger, and to investigate the correlation between antioxidant capacity with both total phenolic and total flavonoid. Ethanolic extracts are fractinationed with n-hexane, chloroform, ethyl acetate, n-butanol, and methanol solvent. Antioxidant capacity, total phenolic, and total flavonoid of all the samples are measured. Highest antioxidant capacity, total phenolic, and total flavonoid obtained from ethyl acetate fraction with TEAC 2143,893 ± 0,890 µmol/g, GAE 229,878 ± 1,330 mg/g, and QE 46,564 ± 1,804 mg/g. One way ANOVA and post hoc analysis show significant result with p value <0,01. Pearson correlation shows high positive correlation.
ASSOCIATION OF DRUG RELATED PROBLEMS (DRPs) OCCURRENCE WITH CLINICAL OUTCOME IN ISCHEMIC STROKE PATIENTS FIRDHA APRILLIA WARDHANI; ZULLIES IKAWATI; NANANG MUNIF YASIN
Majalah Farmaseutik Vol 19, No 1 (2023)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v19i1.74413

Abstract

Ischemic stroke is one of the main causes of death and disability in Indonesia and in the world whose prevalence continues to increase. One of the factors that increase disability in ischemic stroke patients is poor stroke management, and the incidence of DRPs plays a role in it. This study was conducted to determine whether there is a significant relationship between the incidence of DRPs in ischemic stroke patients, and the patient's clinical outcome, which is described by the patient's NIHSS status. It is known that NIHSS is an outcome parameter with the best accuracy and sensitivity compared to other outcome parameters. The study was conducted with a retrospective cross-sectional design, involving 111 samples sourced from the medical records of patients who met the inclusion criteria in the April-October 2021 period. The DRPs analyzed in this study were medication errors, the need for additional drugs, too low drug doses, and drug side effects occur. In this study, DRPs occurred in 88.2% of patients, with the most common type being the need for additional drugs in patients. This study found that the presence of DRPs in ischemic stroke patients, has the potential to increase the risk of patients experiencing clinical outcomes that do not improve as described by the NIHSS status (OR 3,714; p-value<0,05).
Modifiable Comorbidity as a Risk Factor for DRPs and Unimproved NIHSS Score in Ischemic Stroke Patients FIRDHA APRILLIA WARDHANI
Majalah Farmaseutik Vol 19, No 2 (2023)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v19i2.73924

Abstract

Drug-related problems are problems that are often encountered in stroke patients because of the complex management of stroke therapy due to comorbidities. Research shows that 90% of stroke patients experience drug-related problems (DRPs). However, there was limited information regarding the effect of comorbidity as both a risk factor for DRPs prevalence and worse outcomes in an ischemic stroke patient. This research was conducted to see whether modifiable comorbidities indeed had a significant impact as a risk factor for DRPs and clinical outcomes in hospitalized ischemic stroke patients at a tertiary hospital in Indonesia during January 2020-October 2021. This study was conducted retrospectively using cross-sectional analysis, with the subject being the patient's medical record. This study found no significant relationship between the presence of comorbidities in patients with the incidence of DRPs. Diabetes mellitus was found to have a significant association with no improvement in NIHSS scores in ischemic stroke patients. In patients with diabetes mellitus, there is an increased risk of non-improvement NIHSS score 2,987 times compared to patients without diabetes mellitus. The second increased risk was the presence of comorbid hypertension (OR 1.361, 95% CI 0.598-3.095, p-value=0.463), and the third was dyslipidemia (OR 1.125, 95% CI 0.505-2.502, p-value=0.774).
Metode Kiso : Metode Edukasi Bahaya Kortikosteroid Ilegal Dan Dagusibu Di Desa Ajung, Kecamatan Ajung, Kabupaten Jember Khrisna Agung Cendekiawan; Firdha Aprilia Wardhani; Amalia Wardatul Firdaus; Shinta Mayasari
BERNAS: Jurnal Pengabdian Kepada Masyarakat Vol. 4 No. 3 (2023)
Publisher : Universitas Majalengka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31949/jb.v4i3.5681

Abstract

Mayoritas masyarakat Desa Ajung, Kecamatan Ajung, Kabupaten Jember bekerja sebagai buruh kebun dan buruh tani. Keluhan kesehatan yang umumnya muncul adalah nyeri pada otot dan persendian. Perilaku swamedikasi (pengobatan sendiri) menggunakan terapi fisik (pijat) dan obat murah dan mudah dijangkau dijadikan solusi untuk mengatasi keluhan kesehatan tersebut. Di tengah masyarakat Desa Ajung beredar obat sintetis yang mereka kenal sebagai obat dewa karena khasiatnya yang efektif dalam mengatasi keluhan nyeri otot dan persendian. Berdasarkan observasi awal dan evaluasi dari kegiatan pengabdian dosen tentang edukasi penyimpanan obat yang benar, masyarakat Desa Ajung masih banyak melakukan kekeliruan dalam penggunaan obat, misalkan masyarakat menggunakan obat golongan kortikosteroid dengan dosis 2 kali lipat dari dosis yang dianjurkan dengan maksud mempercepat efek terapi, atau menggunakan obat yang sudah disimpan lama dalam jangka waktu setahun karena resep dari dokter. Jenis penelitian ini adalah Pra eksperimen dengan jenis penelitian One-Group Pretest-Posttest Design. Tingkat pengetahuan responden setelah diberikan edukasi DAGUSIBU (Posttest) mengalami peningkatan sebesar 40%. Hal ini menunjukkan bahwa melalui edukasi DAGUSIBU dapat mengurangi atau menghindari terjadi efek samping obat yang tidak diinginkan serta ancaman meningkatnya resistensi tubuh terhadap metabolisme obat yang disebabkan dari kesalahan perilaku pengelolaan obat dalam proses swamedikasi.
Edukasi Tanaman Rempah Untuk Meningkatkan Pengetahuan Pada Karang Taruna Garuda Cempaka di Kelurahan Gebang-Jember Shinta Mayasari; Nafisah Isnawati; Firdha Aprillia; Dyan Wigati; Khrisna Agung; Zulkarnain Permana
BERNAS: Jurnal Pengabdian Kepada Masyarakat Vol. 4 No. 3 (2023)
Publisher : Universitas Majalengka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31949/jb.v4i3.5978

Abstract

Indonesia merupakan salah satu negara dengan keanekaragaman hayati yang tinggi dan terkenal akan tanaman rempah. Tanaman rempah tumbuh disekitar pekarangan rumah didaerah panas sampai sedang. Tanaman rempah dikonsumsi dan dibuat bumbu masakan untuk kehidupan sehari-hari.Selain sebagai bumbu masakan, tanaman rempah dapat digunakan untuk meningkatkan sistem imun dan mengatasi keluhan (symptomp). Tidak hanya di pekarangan, kebun ataupun hutan, tanaman rempah diperjualbelikan di pasar tradisional. Tanaman rempah dikonsumsi dari kalangan remaja hingga lansia dalam sediaan yang beranekaragam dari sediaan seduh simplisia, bubuk kering dan dan jenis tanaman rempah basah. Kegiatan pengabdian yang dilakukan pada karang taruna garuda cempaka yaitu memberikan edukasi terkait tanaman rempah untuk meningkatkan pengetahuan kesehatan akan tanaman rempah selain sebagai bumbu masakan. Sasaran dalam kegiatan pengabdian ini adalah dari kalangan pendidikan SD, SMP, SMA hingga Sarjana. Sejumlah 23 anggota karang taruna yang hadir mengikuti kegiatan. Kegiatan ini dilakukan dengan bertatap muka langsung dan mempraktekkan penjelasan tanaman rempah beserta dengan langkah pembuatannya.Kegiatan pengabdian dilakukan dengan metode ceramah, tanya jawab dan mempraktikkan secara lansung. Pre-test dan post-test dilakukan untuk mengukur tingkat pengetahuan anggota karang taruna dalam pengabdian. Hasil kegiatan pengabdian ini adalah meningkatnya pengetahuan anggota karang taruna akan tanaman rempah.
Metode Kiso : Metode Edukasi Bahaya Kortikosteroid Ilegal Dan Dagusibu Di Desa Ajung, Kecamatan Ajung, Kabupaten Jember Khrisna Agung Cendekiawan; Firdha Aprilia Wardhani; Amalia Wardatul Firdaus; Shinta Mayasari
BERNAS: Jurnal Pengabdian Kepada Masyarakat Vol. 4 No. 3 (2023)
Publisher : Universitas Majalengka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31949/jb.v4i3.5681

Abstract

Mayoritas masyarakat Desa Ajung, Kecamatan Ajung, Kabupaten Jember bekerja sebagai buruh kebun dan buruh tani. Keluhan kesehatan yang umumnya muncul adalah nyeri pada otot dan persendian. Perilaku swamedikasi (pengobatan sendiri) menggunakan terapi fisik (pijat) dan obat murah dan mudah dijangkau dijadikan solusi untuk mengatasi keluhan kesehatan tersebut. Di tengah masyarakat Desa Ajung beredar obat sintetis yang mereka kenal sebagai obat dewa karena khasiatnya yang efektif dalam mengatasi keluhan nyeri otot dan persendian. Berdasarkan observasi awal dan evaluasi dari kegiatan pengabdian dosen tentang edukasi penyimpanan obat yang benar, masyarakat Desa Ajung masih banyak melakukan kekeliruan dalam penggunaan obat, misalkan masyarakat menggunakan obat golongan kortikosteroid dengan dosis 2 kali lipat dari dosis yang dianjurkan dengan maksud mempercepat efek terapi, atau menggunakan obat yang sudah disimpan lama dalam jangka waktu setahun karena resep dari dokter. Jenis penelitian ini adalah Pra eksperimen dengan jenis penelitian One-Group Pretest-Posttest Design. Tingkat pengetahuan responden setelah diberikan edukasi DAGUSIBU (Posttest) mengalami peningkatan sebesar 40%. Hal ini menunjukkan bahwa melalui edukasi DAGUSIBU dapat mengurangi atau menghindari terjadi efek samping obat yang tidak diinginkan serta ancaman meningkatnya resistensi tubuh terhadap metabolisme obat yang disebabkan dari kesalahan perilaku pengelolaan obat dalam proses swamedikasi.
Edukasi Tanaman Rempah Untuk Meningkatkan Pengetahuan Pada Karang Taruna Garuda Cempaka di Kelurahan Gebang-Jember Shinta Mayasari; Nafisah Isnawati; Firdha Aprillia; Dyan Wigati; Khrisna Agung; Zulkarnain Permana
BERNAS: Jurnal Pengabdian Kepada Masyarakat Vol. 4 No. 3 (2023)
Publisher : Universitas Majalengka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31949/jb.v4i3.5978

Abstract

Indonesia merupakan salah satu negara dengan keanekaragaman hayati yang tinggi dan terkenal akan tanaman rempah. Tanaman rempah tumbuh disekitar pekarangan rumah didaerah panas sampai sedang. Tanaman rempah dikonsumsi dan dibuat bumbu masakan untuk kehidupan sehari-hari.Selain sebagai bumbu masakan, tanaman rempah dapat digunakan untuk meningkatkan sistem imun dan mengatasi keluhan (symptomp). Tidak hanya di pekarangan, kebun ataupun hutan, tanaman rempah diperjualbelikan di pasar tradisional. Tanaman rempah dikonsumsi dari kalangan remaja hingga lansia dalam sediaan yang beranekaragam dari sediaan seduh simplisia, bubuk kering dan dan jenis tanaman rempah basah. Kegiatan pengabdian yang dilakukan pada karang taruna garuda cempaka yaitu memberikan edukasi terkait tanaman rempah untuk meningkatkan pengetahuan kesehatan akan tanaman rempah selain sebagai bumbu masakan. Sasaran dalam kegiatan pengabdian ini adalah dari kalangan pendidikan SD, SMP, SMA hingga Sarjana. Sejumlah 23 anggota karang taruna yang hadir mengikuti kegiatan. Kegiatan ini dilakukan dengan bertatap muka langsung dan mempraktekkan penjelasan tanaman rempah beserta dengan langkah pembuatannya.Kegiatan pengabdian dilakukan dengan metode ceramah, tanya jawab dan mempraktikkan secara lansung. Pre-test dan post-test dilakukan untuk mengukur tingkat pengetahuan anggota karang taruna dalam pengabdian. Hasil kegiatan pengabdian ini adalah meningkatnya pengetahuan anggota karang taruna akan tanaman rempah.
Correlation of Polypharmacy and Comorbidity with NIHSS Status in Ischemic Stroke Patient Wardhani, Firdha A.
Pharmacology and Clinical Pharmacy Research Vol 8, No 1 (2023)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v8i1.38919

Abstract

Drug-related problems are a common problem among stroke patients due to comorbidities resulting from the complex management of stroke treatment leading to polypharmacy management. Studies show that 90% of stroke patients have drug-related problems (DRPs). However, there is limited information on the impact of comorbidities as risk factors for DRP prevalence and unfavorable prognosis in patients with ischemic stroke. This study aimed to determine the risk factors for DRP and clinical outcomes as modifiable comorbidities in ischemic stroke patients admitted to a tertiary hospital between January 2020 and October 2021 were indeed significant influences. The study was conducted retrospectively using a cross-sectional analysis of patient’s medical records. The study found no significant association between the presence of comorbidities and polypharmacy in patients with the incidence of DRP, although we found that the DRPs occurrence was found more in a patient with comorbidities and polypharmacy. Diabetes mellitus was found to have a significant association with no improvement in NIHSS scores in ischemic stroke patients. We found that diabetes mellitus patient had an increased risk of non-improvement NIHSS score 2,987 times compared to patients without diabetes mellitus. The second increased risk was the presence of comorbid hypertension (OR 1.352), the third was the occurrence of polypharmacy (OR 1,175), and the fourth was dyslipidemia (OR 1.138).
Evaluation of Pioglitazone Vildagliptin Combination on Lipid Profiles for Outpatients with Type II Diabetes Mellitus Kusumaningrum, Yunita Dyah; Firandi, Adelia; Hasmono, Didik; Aryani, Dhita; Wardhani, Firdha Aprillia
Jurnal FARMASIMED (JFM) Vol 7 No 2 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i2.2645

Abstract

Pioglitazone and vildagliptin combination is one of the recommended alternatives as antidiabetic therapy to achieve the therapeutic target. This combination with complementary mechanisms of action can improve lipid profiles. This study aims to evaluate lipid profile achievement for outpatients with Type II DM on administering pioglitazone/vildagliptin combination therapy. Methods of the study were an observational prospective study in outpatients with Type II DM who use pioglitazone/vildagliptin combination at RS. Bhayangkara Surabaya during November 2021 – April 2022. Patients were included if aged between 18-80 y.o, used this combination ? 3 months before the study, HbA1C >7%, and were voluntarily involved by signing the informed consent. Laboratory examination of HbA1c, HDL-C, and triglycerides was done initially when patients were voluntarily involved as baseline data and after 3 months as post-data. The final sample in this study consisted of 25 patients who met the inclusion and exclusion criteria. The results of the study show mean value of HDL-C significantly increases from baseline to endpoint (p < 0.05). At the end of 3 months, the lipid profile of HDL-C and triglyceride increases by 30% and 4%, respectively, in patients who achieve the target compared to baseline conditions. The combination therapy of pioglitazone and vildagliptin improved lipid profile control in patients with type 2 diabetes mellitus after 3 months of treatment.
Association of Antiplatelet Type on Length of Stay and Neurological Outcomes in Ischemic Stroke Aprillia Wardhani, Firdha
Pharmaceutical Journal of Indonesia Vol. 10 No. 2 (2025)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.pji.2025.010.02.7

Abstract

Antiplatelet therapy plays an important role in preventing the progression of ischemic stroke. However, the effectiveness of different types of antiplatelet agents in improving clinical outcomes still requires further investigation. This study aimed to analyze the relationship between the type of antiplatelet used and the clinical outcomes of hospitalized ischemic stroke patients, based on changes in the National Institutes of Health Stroke Scale (NIHSS) score and length of stay (LoS). This research was a retrospective cross-sectional observational study involving 92 hospitalized patients with ischemic stroke. Patients were grouped based on the antiplatelet therapy received: Clopidogrel (CPG) (n=58), Aspirin (n=17), and dual antiplatelet therapy (DAPT) with Clopidogrel + Aspirin (n=17). Of the total patients, 43 (46.7%) showed improvement in NIHSS score, while 49 (53.2%) did not. The mean LoS was 7.033 days. The proportion of patients with NIHSS improvement by treatment group showed that the CPG group had the highest percentage of improvement, with 30 out of 58 patients (51.72%), compared to Aspirin 7/17 (41.2%) and DAPT 6/17 (35.3%). However, statistical analysis revealed no significant association between the type of antiplatelet and NIHSS improvement (p = 0.431). In addition, Kruskal-Wallis analysis revealed no significant association between LoS and antiplatelet type (p = 0.429). These findings suggest that other factors may play a more substantial role in determining the clinical outcomes of ischemic stroke patients. Keywords: antiplatelet, clinical outcome, NIHSS, ischemic stroke, LoS
Co-Authors Adelia Firandi Amalia Wardatul Firdaus Amalia Wardatul Firdaus Anggraeni, Linda Suci Anggraeni, Lutvi Aryani, Dhita Aryani, Dhita Evi Dea Maulidi Saputri Dian Agung Pangaribowo Didik Hasmono Dwi Koko Pratoko Dyan Wigati Ema Rachmawati Eryani, Mikhania Christiningtyas Fifteen Aprila Fajrin Firandi, Adelia Hasana, Siti Nur Ika Norcahyanti Khrisna Agung Cendekiawan Kintoko Kintoko Kintoko Kintoko Kintoko Kintoko Kintoko, Kintoko Kusumaningrum , Yunita Dyah Lina Winarti Linda Suci Anggraeni Machlaurin, Afifah Nafisah Isnawati Nafisah Isnawati NANANG MUNIF YASIN Neny Poerwahyuningrum Neny Poerwahyuningrum Nia Kristiningrum Ningrum, Lailatul Fitria Nur Sepdianto, Bagas Pontanar, Mae Quenie Ramadhani, Nuril Izzati Farihatur RR. Ella Evrita Hestiandari Sapto Yuliani Sapto Yuliani Sapto Yuliani Shinta Mayasari Shinta Mayasari Sinta Rachmawati Siti Nur Hasana Syafika, Devina Sarah Zulkarnain Permana ZULLIES IKAWATI