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Kadar Fenolat dan Flavonoid Total serta Kapasitas Antioksidan Ekstrak Etanol dan Fraksi Jahe Merah (Zingiber officinale var. Rubrum) Dwi Koko Pratoko; Firdha Aprillia Wardhani; Nia Kristiningrum; Fifteen Aprila Fajrin; Dian Agung Pangaribowo
Al-Kimia Vol 6 No 2 (2018): December
Publisher : Study Program of Chemistry - Alauddin State Islamic University of Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/al-kimia.v6i2.6316

Determination of total phenolic, total flavonoid, and antioxidant capacity of ethanolic extract and fractions from red ginger (Zingiber officinale var. Rubrum) has been done. Red gingers contain the highest oleoresins among other ginger varieties. Oleoresins are component that had the most responsibility for pharmacological effect of red ginger, one of them is as antioxidant. Phenolic and flavonoid are highly contributing to the antioxidant effect of red ginger. The aim of this research is to determine the antioxidant capacity of extract and fractions of red ginger, and to investigate the correlation between antioxidant capacity with both total phenolic and total flavonoid. Ethanolic extracts are fractinationed with n-hexane, chloroform, ethyl acetate, n-butanol, and methanol solvent. Antioxidant capacity, total phenolic, and total flavonoid of all the samples are measured. Highest antioxidant capacity, total phenolic, and total flavonoid obtained from ethyl acetate fraction with TEAC 2143.9 ± 0.9 µmol/g (CUPRAC) and 4526.4 ± 3.0 (DPPH), GAE 229.9 ± 1.3 mg/g, and QE 46,6 ± 1,8 mg/g. One way ANOVA and post hoc analysis show significant result with p value <0,01. Pearson correlation shows high positive correlation. Determination of total phenolic, total flavonoid, antioxidant capacity from ethanolic extract and fractions of red ginger (Zingiber officinale var. Rubrum) has been done.Red ginger contain the highest oleoresins among other ginger varieties. Oleoresins are component that had the most responsibility for pharmacological effect of red ginger, one of them is as antioxidant. Phenolic and flavonoid are highly contribute to the antioxidant effect of red ginger. The aim of this research is to determine the antioxidant capacity of extract and fractions of red ginger, and to investigate the correlation between antioxidant capacity with both total phenolic and total flavonoid. Ethanolic extracts are fractinationed with n-hexane, chloroform, ethyl acetate, n-butanol, and methanol solvent. Antioxidant capacity, total phenolic, and total flavonoid of all the samples are measured. Highest antioxidant capacity, total phenolic, and total flavonoid obtained from ethyl acetate fraction with TEAC 2143,893 ± 0,890 µmol/g, GAE 229,878 ± 1,330 mg/g, and QE 46,564 ± 1,804 mg/g. One way ANOVA and post hoc analysis show significant result with p value <0,01. Pearson correlation shows high positive correlation.

ASSOCIATION OF DRUG RELATED PROBLEMS (DRPs) OCCURRENCE WITH CLINICAL OUTCOME IN ISCHEMIC STROKE PATIENTS FIRDHA APRILLIA WARDHANI; ZULLIES IKAWATI; NANANG MUNIF YASIN
Majalah Farmaseutik Vol 19, No 1 (2023)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v19i1.74413

Ischemic stroke is one of the main causes of death and disability in Indonesia and in the world whose prevalence continues to increase. One of the factors that increase disability in ischemic stroke patients is poor stroke management, and the incidence of DRPs plays a role in it. This study was conducted to determine whether there is a significant relationship between the incidence of DRPs in ischemic stroke patients, and the patient's clinical outcome, which is described by the patient's NIHSS status. It is known that NIHSS is an outcome parameter with the best accuracy and sensitivity compared to other outcome parameters. The study was conducted with a retrospective cross-sectional design, involving 111 samples sourced from the medical records of patients who met the inclusion criteria in the April-October 2021 period. The DRPs analyzed in this study were medication errors, the need for additional drugs, too low drug doses, and drug side effects occur. In this study, DRPs occurred in 88.2% of patients, with the most common type being the need for additional drugs in patients. This study found that the presence of DRPs in ischemic stroke patients, has the potential to increase the risk of patients experiencing clinical outcomes that do not improve as described by the NIHSS status (OR 3,714; p-value<0,05).

Modifiable Comorbidity as a Risk Factor for DRPs and Unimproved NIHSS Score in Ischemic Stroke Patients FIRDHA APRILLIA WARDHANI
Majalah Farmaseutik Vol 19, No 2 (2023)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v19i2.73924

Drug-related problems are problems that are often encountered in stroke patients because of the complex management of stroke therapy due to comorbidities. Research shows that 90% of stroke patients experience drug-related problems (DRPs). However, there was limited information regarding the effect of comorbidity as both a risk factor for DRPs prevalence and worse outcomes in an ischemic stroke patient. This research was conducted to see whether modifiable comorbidities indeed had a significant impact as a risk factor for DRPs and clinical outcomes in hospitalized ischemic stroke patients at a tertiary hospital in Indonesia during January 2020-October 2021. This study was conducted retrospectively using cross-sectional analysis, with the subject being the patient's medical record. This study found no significant relationship between the presence of comorbidities in patients with the incidence of DRPs. Diabetes mellitus was found to have a significant association with no improvement in NIHSS scores in ischemic stroke patients. In patients with diabetes mellitus, there is an increased risk of non-improvement NIHSS score 2,987 times compared to patients without diabetes mellitus. The second increased risk was the presence of comorbid hypertension (OR 1.361, 95% CI 0.598-3.095, p-value=0.463), and the third was dyslipidemia (OR 1.125, 95% CI 0.505-2.502, p-value=0.774).

Edukasi Tanaman Rempah Untuk Meningkatkan Pengetahuan Pada Karang Taruna Garuda Cempaka di Kelurahan Gebang-Jember Shinta Mayasari; Nafisah Isnawati; Firdha Aprillia; Dyan Wigati; Khrisna Agung; Zulkarnain Permana
BERNAS: Jurnal Pengabdian Kepada Masyarakat Vol. 4 No. 3 (2023)
Publisher : Universitas Majalengka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31949/jb.v4i3.5978

Indonesia merupakan salah satu negara dengan keanekaragaman hayati yang tinggi dan terkenal akan tanaman rempah. Tanaman rempah tumbuh disekitar pekarangan rumah didaerah panas sampai sedang. Tanaman rempah dikonsumsi dan dibuat bumbu masakan untuk kehidupan sehari-hari.Selain sebagai bumbu masakan, tanaman rempah dapat digunakan untuk meningkatkan sistem imun dan mengatasi keluhan (symptomp). Tidak hanya di pekarangan, kebun ataupun hutan, tanaman rempah diperjualbelikan di pasar tradisional. Tanaman rempah dikonsumsi dari kalangan remaja hingga lansia dalam sediaan yang beranekaragam dari sediaan seduh simplisia, bubuk kering dan dan jenis tanaman rempah basah. Kegiatan pengabdian yang dilakukan pada karang taruna garuda cempaka yaitu memberikan edukasi terkait tanaman rempah untuk meningkatkan pengetahuan kesehatan akan tanaman rempah selain sebagai bumbu masakan. Sasaran dalam kegiatan pengabdian ini adalah dari kalangan pendidikan SD, SMP, SMA hingga Sarjana. Sejumlah 23 anggota karang taruna yang hadir mengikuti kegiatan. Kegiatan ini dilakukan dengan bertatap muka langsung dan mempraktekkan penjelasan tanaman rempah beserta dengan langkah pembuatannya.Kegiatan pengabdian dilakukan dengan metode ceramah, tanya jawab dan mempraktikkan secara lansung. Pre-test dan post-test dilakukan untuk mengukur tingkat pengetahuan anggota karang taruna dalam pengabdian. Hasil kegiatan pengabdian ini adalah meningkatnya pengetahuan anggota karang taruna akan tanaman rempah.

Peningkatan Edukasi Stroke Masyarakat dengan Video Edukasi Stroke – “CHERIE” (Cerebral Hemorrhage and Ischemic Educational Video) Firdha Aprillia Wardhani; Amalia Wardatul Firdaus; Shinta Mayasari
Jurnal Pengabdian Masyarakat (JUDIMAS) Vol. 1 No. 2 (2023): Juli 2023
Publisher : Pusat Penelitian dan Pengabdian Masyarakat STIKes Banyuwangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54832/judimas.v1i2.163

Berdasarkan data Kementerian Kesehatan, stroke merupakan penyebab kematian pertama untuk semua umur dengan persentase 15,4 persen, dan stroke juga menempati urutan pertama penyakit tidak menular yang mematikan. Time window yang ditujukan untuk pengobatan stroke adalah tiga jam, sehingga pengenalan gejala stroke sedini mungkin kepada masyarakat sangat penting. Tujuan Pengabdian masyarakat ini adalah untuk mengedukasi masyarakat dengan video edukasi stroke CHERIE (Cerebral Hemorrhage and Ischemic Educational Video) bagi masyarakat untuk lebih memahami penyakit stroke, mulai dari gejala hingga petunjuk penggunaan obat. Sasaran kegiatan ini adalah masyarakat umum di wilayah kabupaten Jember. Metode yang digunakan adalah memberikan edukasi dan mengukur tingkat pengetahuan melalui pretest dan post-test untuk mengetahui perubahan tingkat pengetahuan. Hasil dari kegiatan ini, sasaran mengalami peningkatan pengetahuan dengan rata-rata 42,8%, dengan nilai rata-rata pretest sebesar 68, dan rata-rata nilai post-test sebesar 95,3. Sehingga dapat disimpulkan bahwa kegiatan Pengabdian masyarakat dalam Upaya peningkatan edukasi masyarakat mengenai stroke melalui video CHERIE cukup efektif dalam meningkatkan pengetahuan masyarakat.

Edukasi Tanaman Rempah Untuk Meningkatkan Pengetahuan Pada Karang Taruna Garuda Cempaka di Kelurahan Gebang-Jember Shinta Mayasari; Nafisah Isnawati; Firdha Aprillia; Dyan Wigati; Khrisna Agung; Zulkarnain Permana
BERNAS: Jurnal Pengabdian Kepada Masyarakat Vol. 4 No. 3 (2023)
Publisher : Universitas Majalengka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31949/jb.v4i3.5978

Indonesia merupakan salah satu negara dengan keanekaragaman hayati yang tinggi dan terkenal akan tanaman rempah. Tanaman rempah tumbuh disekitar pekarangan rumah didaerah panas sampai sedang. Tanaman rempah dikonsumsi dan dibuat bumbu masakan untuk kehidupan sehari-hari.Selain sebagai bumbu masakan, tanaman rempah dapat digunakan untuk meningkatkan sistem imun dan mengatasi keluhan (symptomp). Tidak hanya di pekarangan, kebun ataupun hutan, tanaman rempah diperjualbelikan di pasar tradisional. Tanaman rempah dikonsumsi dari kalangan remaja hingga lansia dalam sediaan yang beranekaragam dari sediaan seduh simplisia, bubuk kering dan dan jenis tanaman rempah basah. Kegiatan pengabdian yang dilakukan pada karang taruna garuda cempaka yaitu memberikan edukasi terkait tanaman rempah untuk meningkatkan pengetahuan kesehatan akan tanaman rempah selain sebagai bumbu masakan. Sasaran dalam kegiatan pengabdian ini adalah dari kalangan pendidikan SD, SMP, SMA hingga Sarjana. Sejumlah 23 anggota karang taruna yang hadir mengikuti kegiatan. Kegiatan ini dilakukan dengan bertatap muka langsung dan mempraktekkan penjelasan tanaman rempah beserta dengan langkah pembuatannya.Kegiatan pengabdian dilakukan dengan metode ceramah, tanya jawab dan mempraktikkan secara lansung. Pre-test dan post-test dilakukan untuk mengukur tingkat pengetahuan anggota karang taruna dalam pengabdian. Hasil kegiatan pengabdian ini adalah meningkatnya pengetahuan anggota karang taruna akan tanaman rempah.

Baricitinib for the treatment of COVID-19 Firdha Aprillia Wardhani; Devina Sarah Syafika; Yunita Dyah Kusumaningrum; Adelia Firandi
Journal of Agropharmacy Vol. 1 No. 2 (2024)
Publisher : Faculty of Pharmacy, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/joa.v1i2.1422

Baricitinib which is one of the therapies for rheumatoid arthritis is a JAK inhibitor. WHO recommended therapy with the combination of baricitinib and corticosteroids in COVID-19 patients with severe or critical condition. Effectivity and safety assessment of Baricitinib use were carried out by reviewing the literature published between December 2019 – February 2022, and showed that the use of Baricitinib in COVID-19 patients resulted in an improvement of lung function, improvement of oxygen saturation, higher recovery rate, and lower mortality, with similar adverse event incidence. A loading dose or a higher dose can be recommended for patient with caution and consideration of higher possibility in the incidence of adverse events

Evaluasi Perencanaan dan Pengadaan Obat dengan Dana JKN di Puskesmas Rambipuji Jember Ika Norcahyanti; Adelia Firandi; Nuril Izzati Farihatur Ramadhani; Sinta Rachmawati; Ema Rachmawati; Dhita Evi Aryani; Firdha Aprillia Wardhani; Yunita Dyah Kusumaningrum
Journal of Agropharmacy Vol. 1 No. 3 (2024)
Publisher : Faculty of Pharmacy, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/joa.v1i3.1811

Public Health Center is a health facility that organizes drug management activities, including planning and procurement activities. Evaluation needs to assess the success of achieving the objectives and results of the action. Indicators that can use are efficiency indicators published by the Ministry of Health of the Republic of Indonesia and efficiency indicators developed by Pudjaningsih. Rambipuji Public Health Center with spending funds for the most significant drug procurement in Jember Regency in 2020. Therefore, it is necessary to evaluate the results that can improve the quality of service in the next period. This research aims to determine the results of the evaluation of drug planning and procurement with JKN funds at Rambipuji Public Health Center for 2020. This research is descriptive, primary data through interview results. Secondary data includes total funds available, drug procurement funds, Drug Usage Reports, and Drug Demand Sheets for drugs purchased through JKN funds and stock cards. The data is analyzed descriptively, presented in the form of tables supported by interview results. The results showed that the Government of Indonesia had governed drug planning and procurement activities with JKN funds. The percentage indicator of available funds compared to the general funds needed is 114.26%. The percentage indicator of drug procurement fund allocation is 3.46%. Results on percentage indicator procurement conformity with the reality of the use of each drug item amounted to 133.33% and on the procurement frequency indicator of each drug item once a year. Through this research, it can be concluded that the evaluation results on indicators of the efficiency of drug planning and procurement activities at Rambipuji Public Health Center have not been by established standards. This matter was influenced by several factors, including a decrease in the number of patient visits due to the COVID-19 pandemic, changes in the organizational structure in the Jember Health Office that resulted in the frequency of procurement activities only once throughout 2020, and the absence of government regulations that regulate in more detail about the percentage of JKN funds allowed for drug procurement activities.

Evaluation of Pioglitazone Vildagliptin Combination on Lipid Profiles for Outpatients with Type II Diabetes Mellitus Kusumaningrum, Yunita Dyah; Firandi, Adelia; Hasmono, Didik; Aryani, Dhita; Wardhani, Firdha Aprillia
Jurnal FARMASIMED (JFM) Vol 7 No 2 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i2.2645

Pioglitazone and vildagliptin combination is one of the recommended alternatives as antidiabetic therapy to achieve the therapeutic target. This combination with complementary mechanisms of action can improve lipid profiles. This study aims to evaluate lipid profile achievement for outpatients with Type II DM on administering pioglitazone/vildagliptin combination therapy. Methods of the study were an observational prospective study in outpatients with Type II DM who use pioglitazone/vildagliptin combination at RS. Bhayangkara Surabaya during November 2021 – April 2022. Patients were included if aged between 18-80 y.o, used this combination ? 3 months before the study, HbA1C >7%, and were voluntarily involved by signing the informed consent. Laboratory examination of HbA1c, HDL-C, and triglycerides was done initially when patients were voluntarily involved as baseline data and after 3 months as post-data. The final sample in this study consisted of 25 patients who met the inclusion and exclusion criteria. The results of the study show mean value of HDL-C significantly increases from baseline to endpoint (p < 0.05). At the end of 3 months, the lipid profile of HDL-C and triglyceride increases by 30% and 4%, respectively, in patients who achieve the target compared to baseline conditions. The combination therapy of pioglitazone and vildagliptin improved lipid profile control in patients with type 2 diabetes mellitus after 3 months of treatment.

Association of Antiplatelet Type on Length of Stay and Neurological Outcomes in Ischemic Stroke Aprillia Wardhani, Firdha
Pharmaceutical Journal of Indonesia Vol. 10 No. 2 (2025)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/

Antiplatelet therapy plays an important role in preventing the progression of ischemic stroke. However, the effectiveness of different types of antiplatelet agents in improving clinical outcomes still requires further investigation. This study aimed to analyze the relationship between the type of antiplatelet used and the clinical outcomes of hospitalized ischemic stroke patients, based on changes in the National Institutes of Health Stroke Scale (NIHSS) score and length of stay (LoS). This research was a retrospective cross-sectional observational study involving 92 hospitalized patients with ischemic stroke. Patients were grouped based on the antiplatelet therapy received: Clopidogrel (CPG) (n=58), Aspirin (n=17), and dual antiplatelet therapy (DAPT) with Clopidogrel + Aspirin (n=17). Of the total patients, 43 (46.7%) showed improvement in NIHSS score, while 49 (53.2%) did not. The mean LoS was 7.033 days. The proportion of patients with NIHSS improvement by treatment group showed that the CPG group had the highest percentage of improvement, with 30 out of 58 patients (51.72%), compared to Aspirin 7/17 (41.2%) and DAPT 6/17 (35.3%). However, statistical analysis revealed no significant association between the type of antiplatelet and NIHSS improvement (p = 0.431). In addition, Kruskal-Wallis analysis revealed no significant association between LoS and antiplatelet type (p = 0.429). These findings suggest that other factors may play a more substantial role in determining the clinical outcomes of ischemic stroke patients. Keywords: antiplatelet, clinical outcome, NIHSS, ischemic stroke, LoS

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