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All Journal Diponegoro Journal of Management Biosfer: Jurnal Tadris Biologi
Dea Ananda Putri, Dea
Jurusan Manajemen Fakultas Ekonomika dan Bisnis Universitas Diponegoro
Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Education Immunology & microbiology Social Sciences Other

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ANALISIS PENGARUH KEPUASAN KERJA DAN KOMITMEN ORGANISASI TERHADAP KINERJA KARYAWAN (Studi pada BPJS Kesehatan Cabang Utama Surakarta) Ananda Putri, Dea; Rahardjo, Mudji
Diponegoro Journal of Management Volume 4, Nomor 2, Tahun 2015
Publisher : Faculty of Economics and Business Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (226.743 KB)

Abstract

Job satisfaction and organizational commitment affect employee performance. The purpose of this research is to explain how the variable of job satisfaction and organizational commitment influence to BPJS Kesehatan Cabang Utama Surakarta employee performance. In addition to recognize which variable influences dominantly to the employee performance.The data of this research were collected through a questionnaire distributed to 65 employees of BPJS Kesehatan Cabang Utama Surakarta. Mechanical testing of the data  used  in  this  research  include  the  instrument  test  (validity  and  reliability  test), classical assumption test (normality test, multicoloniarity, and heteroscedasticity test), multiple linear regression analysis, t test, F test, and coefficient of determination test (R2) using SPSS application.The  result  of  this  research  shows  that  job  satisfaction  and  organizational commitment influence positively and significantly to theemployee performance. Variable used   in   this   research   give   positive   response,   meaning   the   job   satisfaction   and organizational commitment improving the performance of BPJS Kesehatan Cabang Utama Surakarta employee. Value of determination coefficient or R2 is 0,364, which means employee performance is affected by job satisfaction and organizational commitment amounted to 36,4%
Histopathological Evidence of Nephrotoxicity in Mice Administered Arcangelisia flava (L.) Merr. Stem Extract from Enggano Island Nurul Kamilah, Santi; Muslim, Choirul; Hermawati, Ely; Maulana, Sherlo Adha; Fita Lestari, Dian; Sri Astuti, R.R.; Ezer Simanungkalit, Eben; Siti Fitri Andriyani, Eka; Ananda Putri, Dea
Biosfer: Jurnal Tadris Biologi Vol 17 No 1 (2026): Biosfer: Jurnal Tadris Biologi
Publisher : UNIVERSITAS ISLAM NEGERI RADEN INTAN LAMPUNG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24042/biosfer.v17i1.27294

Abstract

Arcangelisia flava (L.) Merr., an endemic Indonesian forest plant, is traditionally consumed as an aphrodisiac by the Enggano Island community, yet its safety profile remains poorly documented. This study evaluated the nephrotoxic potential of A. flava stem extract using a murine model. Fifteen ICR mice were randomly assigned to a control group receiving distilled water and a treatment group receiving 200 mg/kg body weight of ethanolic stem extract orally for 14 days. Kidney tissues were processed for hematoxylin-eosin staining and semi-quantitative histopathological scoring. Compared with controls, treated mice showed higher damage scores in the glomerulus, proximal tubule, and distal tubule, along with a reduction in glomerular diameter. Histopathological findings included podocytopenia, widened Bowman’s space, proximal tubular brush border loss, apoptotic changes, and ablation of macula densa and distal tubular epithelial cells. These findings indicate nephrotoxic activity of A. flava stem extract and highlight the need for dosage standardization before use. Bukti Histopatologis Nefrotoksisitas pada Tikus yang Diberikan Arcangelisia flava (L.) Merr. Ekstrak Batang dari Pulau Enggano ABSTRAK: Arcangelisia flava (L.) Merr. merupakan tumbuhan endemik hutan Indonesia yang secara tradisional dimanfaatkan sebagai afrodisiak oleh masyarakat Pulau Enggano, namun aspek keamanannya masih belum terdokumentasi dengan baik. Penelitian ini bertujuan mengevaluasi potensi nefrotoksik ekstrak batang A. flava menggunakan model mencit. Sebanyak 15 ekor mencit jantan galur ICR dibagi acak ke dalam kelompok kontrol yang diberi akuades dan kelompok perlakuan yang diberi ekstrak etanol batang A. flava dosis 200 mg/kg bobot badan secara oral selama 14 hari. Jaringan ginjal diproses dengan pewarnaan hematoksilin-eosin dan dianalisis menggunakan skor kerusakan histopatologi semi-kuantitatif. Dibandingkan kontrol, kelompok perlakuan menunjukkan skor kerusakan lebih tinggi pada glomerulus, tubulus proksimal, dan tubulus distal, serta penurunan diameter glomerulus. Temuan histopatologi meliputi podositopenia, pelebaran ruang Bowman, hilangnya brush border tubulus proksimal, perubahan apoptosis, serta ablasi makula densa dan sel epitel tubulus distal. Hasil ini menunjukkan aktivitas nefrotoksik ekstrak batang A. flava.
Co-Authors CHOIRUL MUSLIM Ezer Simanungkalit, Eben Fita Lestari, Dian Hermawati, Ely Maulana, Sherlo Adha Mudji Rahardjo Nurul Kamilah, Santi Siti Fitri Andriyani, Eka Sri Astuti, R.R.