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All Journal WMJ (Warmadewa Medical Journal) Mandala of Health : A Scientific Journal
Norina Agatri
Universitas Muhammadiyah Purwokerto
Dentistry Health Professions Medicine & Pharmacology Public Health

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SEBARAN IBU PEROKOK PASIF DENGAN KEHAMILAN Edy Priyanto; Norina Agatri
Mandala Of Health Vol 13 No 2 (2021): Mandala Of Health
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2021.13.2.8408

Abstract

Latar belakang : Perokok pasif didefinisikan sebagai orang yang menghirup asap dari ujung batang rokok yang menyala dan dari asap yang dihembuskan oleh perokok lain. Hal ini berdampak pada kesehatannya tak terkecuali ibu hamil karena asap rokok melintasi plasenta, menginduksi komplikasi kehamilan, mengurangi pertumbuhan janin intrauterin dan meningkatkan risiko kelahiran prematur. Penelitian ini bertujuan untuk mengetahui sebaran yang dapat berakibat dampak perokok pasif terhadap komplikasi kehamilanMetode : Rancangan deskriptif observasional dengan data meliputi identitas dan status perokok aktif maupun pasif didapatkan dengan metode consecutive sampling melalui kuesioner yang diisi oleh pasien saat masuk serta yang bersedia diikutkan dalam penelitian sedangkan data yang berkaitan dengan medis didapatkan dari catatan medis pasien di RSIA Bunda arif Purwokerto periode Januari 2019 - Desember 2020 dengan kriteria inklusi komplikasi yang terjadi hanya tunggal pada maternal atau perinatal.Hasil : Perokok pasif yang bersalin di RSIA Bunda arif periode Januari 2019 - Desember 2020 sebanyak 911 orang (37,1 %) dari 2450 ibu hamil. 777 orang (85,2 %) ibu hamil perokok pasif mengalami komplikasi kehamilan. Komplikasi terbanyak pada maternal, 223 orang (24,4%) mengalami persalinan lama dan yang terendah terjadinya perdarahan pasca salin, 21 orang (2,3%). Untuk komplikasi pada bayi, asfiksi mendominasi kejadiannya 61 (6,6%).Simpulan : Penelitian ini merupakan penelitian pendahuluan yang mendapatkan sebaran komplikasi maternal atau perinatal perokok pasif pada ibu hamil berupa pre eklampsia, diabetes gestasional, persalinan prematur, persalinan lewat waktu, riwayat abortus iminens, perdarahan ante partum, perdarahan pasca salin, persalinan lama, kecil masa kehamilan (KMK), intrauterine growth restriction (IUGR), intrauterine fetal death (IUFD), asfiksia dan kelainan kongenital.
Role of Secretome in Age-related Changes in the Male Reproductive System: An Add-on Review on the Gut-Brain Axis Gembong Satria Mahardhika; Norina Agatri
WMJ (Warmadewa Medical Journal) Vol 10 No 2 (2025): November
Publisher : Warmadewa University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/wmj.10.2.10116.110-116

Abstract

Humans are unable to prevent the ageing process. The secretome is a group of bioactive molecules released by cells that may exert paracrine effects on adjacent cells. Recent research indicates that the cellular secretome of mesenchymal stem cells (MSCs) may be useful in the management of idiopathic male infertility. This narrative review was derived from journal articles retrieved through various search engines, including PubMed, Google Scholar, and EBSCO, which were used to compile the reference list. Subsequently, relevant information and journals were collected and reviewed by the authors. The secretome can be examined from multiple perspectives. It may be linked to morphological, histological, and physiological changes in the male reproductive system associated with ageing. These processes may be improved by incorporating the secretome as an anti-inflammatory, anti-apoptotic, and anti-aging agent. Normal gut–testis microbial cooperation supports overall health. Food intake or illness can disrupt the gut microbiota, triggering a cascade that affects fertility. Dysbiotic conditions increase inflammatory markers and damage the gut epithelium, allowing bacteria and inflammatory cytokines to enter the circulation. The secretome also plays a role in balancing the microbiome within the gut–brain axis, thereby contributing to the prevention of fertility impairment. The presence of the secretome may serve as a modulatory factor for age-related changes in male reproductive function, particularly fertility components. Further investigation through additional related studies and systematic reviews is needed to enhance understanding of the relationship between these variables.
Co-Authors Edy Priyanto Gembong Satria Mahardhika