Article Per Year (5 Year)
p-Index From 2021 - 2026
0.444
P-Index
This Author published in this journals
All Journal Adi Widya : Jurnal Pengabdian Masyarakat Open Access Health Scientific Journal
Muhammad Dzakwan
Universitas Setia Budi
Dentistry Health Professions Nursing Public Health Social Sciences Veterinary Other

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Peningkatan Kualitas dan Kuantitas Produksi Pengrajin Jamu melalui Cara Pembuatan Obat Tradisional yang Baik (CPOTB) dan Pengemasan Sunardi Sunardi; Argoto Mahayana; Widi Hariyanti; Sugiyarmasto Sugiyarmasto; Muhammad Dzakwan
Adi Widya : Jurnal Pengabdian Masyarakat Vol. 7 No. 1 (2023): Adi Widya: Jurnal Pengabdian Masyarakat
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33061/awpm.v7i1.8316

Abstract

Traditional medicine / herbal medicine is a product consumed by many people, so the security aspect must be maintained. In order for herbal products to be safely consumed, herbal medicine producers must understand and apply sanitation and hygiene in their production processes and packaging methods. The community service activities aim to improve the knowledge and skills of herbal medicine craftsmen about sanitation and herbal hygiene production and how to pack using continuous sealer machines. This activity was held at PJ SUTI SEHATI, having its address at Pengkol RT 02 RW 1 Nguter Sukoharjo and PJ Bintang Mas having the address at Tenongan RT 2 RW 1 Gupit Nguter Sukoharjo. The form of the activity is providing counseling (lectures and question and answer), training and mentoring. The target of the activity is the leader / owner and employees of herbal medicine craftsmen. The steps of the activity include, preparation, implementation and evaluation. The participants received an explanation of sanitation and hygiene and how to pack using continuous sealer machines. Evaluation has been carried out after service activities which result in packaging using a continuous sealer machine 3-4 times faster and more hygienic.
Formulation and Characterization of Myricetin Solid Lipid Nanoparticles (SLNs) via Ultrasonication Method Dewi Zulfa Rosida; Muhammad Dzakwan; Hery Muhamad Ansory
Open Access Health Scientific Journal Vol. 7 No. 2 (2026): August 2026
Publisher : Griya Eka Sejahtera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55700/oahsj.v7i2.235

Abstract

Background: Myricetin is a flavonol flavonoid with promising neuroprotective and antioxidant activities. However, its therapeutic application is severely limited by poor water solubility and a low dissolution rate. This study aimed to enhance the solubility and formulation stability of myricetin by developing a Solid Lipid Nanoparticle (SLN) delivery system.Methods: Myricetin-SLNs were prepared via the ultrasonication method using Tween 80 as a nonionic surfactant. Lipid screening was conducted using Imwitor 491, Dynasan 118, and Apifil at concentrations of 2%, 4%, and 6%. The selected lipid (Apifil at 2%, 3%, 4%, and 5%) was melted at 100 °C, homogenized with the aqueous phase using a magnetic stirrer at 2000 rpm for 1 hour, cooled to 35 °C, and subjected to probe ultrasonication at 35 kHz for 5 minutes. The SLNs were characterized using a particle size analyzer and a UV-Vis spectrophotometer to evaluate storage stability, particle size, polydispersity index (PDI), entrapment efficiency, zeta potential, and DPPH free radical scavenging activity.Results: Lipid screening revealed that Apifil-based formulations provided superior physical stability compared to Imwitor 491 and Dynasan 118. The optimized formulation, F7 (containing 2% Apifil), yielded the smallest particle size of 105.5±0.70 nm, a highly homogeneous PDI of 0.232, a zeta potential of -20.52 mV, and the highest entrapment efficiency at 73.56%. Furthermore, F7 demonstrated strong antioxidant activity with an IC50 value of 38.77 ppm, compared to pure myricetin (14.44 ppm).Conclusion: The formulation of myricetin into Solid Lipid Nanoparticles using 2% Apifil via ultrasonication effectively minimizes particle size and maximizes entrapment efficiency. Although it exhibits lower long-term storage stability at room temperature, it successfully preserves potent antioxidant activity, offering a promising approach for health sciences and advanced drug delivery applications
Co-Authors Argoto Mahayana Dewi Zulfa Rosida Muhamad Ansory, Hery Sugiyarmasto Sugiyarmasto Sunardi Sunardi Widi Hariyanti