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All Journal Fullerene Journal of Chemistry Stannum : Jurnal Sains dan Terapan Kimia
Khoirotul Ummah
Departement Of Science Education, UIN Sunan Ampel Surabaya, Wonocolo, Surabaya, 60237, Indonesia
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry

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Analisis Produk Reaksi α-Hidroksilasi Keton pada Senyawa Turunan Eugenol Menggunakan Katalis Iodin Khoirotul Ummah
Jurnal Kimia Fullerene Vol 7 No 2 (2022): Fullerene Journal of Chemistry
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37033/fjc.v7i2.452

Abstract

Senyawa turunan eugenol memiliki berbagai sifat farmakologi sebagai antioksidan, antibakteri dan antiinflamasi. Senyawa turunan eugenol juga banyak dijadikan sebagai prekursor dalam berbagai sintesis senyawa lain yang memiliki potensial lebih tinggi melalui transformasi gugus fungsinya. Dalam penelitian ini dilakukan transformasi gugus fungsi pada senyawa turunan eugenol melalui reaksi α-hidroksilasi keton. Proses reaksi hidroksilasi keton dilakukan menggunakan katalis I2 20% mol dan pelarut dimetil sulfoksida (DMSO) selama 28 jam pada suhu ruang. Senyawa hasil reaksi berupa campuran empat senyawa dan dipisahkan menggunakan kolom kromatografi serta dikarakterisasi menggunakan spektroskopi FTIR, MS dan NMR. Produk yang dihasilkan dari reaksi tersebut yaitu senyawa 1-hidroksi-1-(4-hidroksi-3-metoksifenil)-propan-2-on (1), senyawa 1-(4-hidroksi-3-metoksifenil)-propan-1,2-dion (2), senyawa vanillin (3) dan senyawa 1-(4-hidroksi-3-metoksi-fenil)-1-iodo-propan-2-on (4).
Synthesis of Iodo Quinolinone Stefan Marco Rumengan; Khoirotul Ummah
Jurnal Kimia Fullerene Vol 8 No 1 (2023): Fullerene Journal of Chemistry
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37033/fjc.v8i1.500

Abstract

Quinolones are important heterocyclic compounds in medicine and materials for DSSC or OLED. This study aims to make a quinolinone framework that has several functional groups. These functional groups can be coupled with various other heterocyclic compounds. The synthesis of the target compound consists of forming a quinolinone framework using phenyldiamine and ethyl aceto acetate via the Penchmann reaction then iodination using ICl. The Penchmann reaction succeeded in forming a quinolinone framework as indicated by shown a proton signal at 11.22 ppm. The iodination reaction was successfully carried out by adding iodo to the benzene ring and the appearance peak of (M+H) m/z was 300.9839 on mass spectroscopy. The compound 7-amino-8-iodo-4-methyl-2-quinolinone (compound 2) has been successfully synthesized. Compound 2 has 3 functional groups (amine, iodo and alkene) that can be used for coupling with the other heterocycles.
Synthesis of Diazo Quinolinone Stefan Marco Rumengan; Khoirotul Ummah; Robby Gus Mahardika; Ana Mardliyah; Mariam Ulfah; Ajeng Triane Syawila
Jurnal Kimia Fullerene Vol 8 No 2 (2023): Fullerene Journal of Chemistry
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37033/fjc.v8i2.600

Abstract

Quinolones are important heterocyclic compounds in medicine and materials for DSSC or OLED. This study aims to make a quinolinone framework that has several functional groups. These functional groups can be coupled with various other heterocyclic compounds. The synthesis of the target compound consists of forming a quinolinone framework using phenyldiamine and ethyl aceto acetate via the Penchmann reaction then iodination using ICl. The Penchmann reaction succeeded in forming a quinolinone framework as indicated by shown a proton signal at 11.22 ppm. The iodination reaction was successfully carried out by adding iodo to the benzene ring and the appearance peak of (M+H) m/z was 300.9839 on mass spectroscopy. The compound 7-amino-8-iodo-4-methyl-2-quinolinone (compound 2) has been successfully synthesized. Compound 2 has 3 functional groups (amine, iodo and alkene) that can be used for coupling with the other heterocycles.
In Silico Study of Pomegranate Peel Polyphenols as Breast Anticancer Khoirotul Ummah; Atiqoh Zummah
Stannum : Jurnal Sains dan Terapan Kimia Vol 6 No 1 (2024): April 2024
Publisher : Department of Chemistry - Universitas Bangka Belitung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33019/jstk.v6i1.4817

Abstract

Breast cancer is one of the causes of women’s death. Estrogen-α receptors are one of the targets for breast cancer treatment because it plays a role in cancer cell proliferation. Several studies have stated that Flavonoid compounds have high activity in inhibiting the growth of breast cancer cells. This study aims to inhibit polyphenolic compounds in pomegranate peel (gallic acid, cafeic acid, ellagic acid, and chlorogenic acid) against estrogen receptors-α through molecular docking. The 3D structures of the polyphenolic compounds were obtained from the PubChem database and the estrogen-α receptors from the Protein Data Base. Molecular docking simulations were carried out using AutoDock Vina and supporting software such as Biovia Discovery Studio Client 4.1, AutoDockTools 1.5.6, PyMOL, and LigPlot. The results showed that the four polyphenolic compounds had a better potential to inhibit estrogen-α receptors than tamoxifen. The inhibitory potential is evidenced by the low affinity of ligand-protein binding energy (approximately -5.4 to -9.0 kcal/mol). The phenol group of polyphenolic compounds can strengthen the ligand-protein interactions through hydrogen bonds with the active site of ER-ꭤ proteins. Hydrophobic and π-π stacking interactions between polyphenolic and the active site of proteins also support the inhibition potential of polyphenolic compounds. The conclusion is that the polyphenolic compounds in pomegranate peel have the potential as breast anticancers.
Analysis of Diazo Quinolinone Complexes with Various Metal Ions Stefan Marco Rumengan; Khoirotul Ummah; Ana Mardliyah; Jefry Wijaya; Febrindah Ester Tambalean; Soenandar Milian Tengker; Abdon Saiya; Marlina Karundeng; Vlagia Indira Paat
Stannum : Jurnal Sains dan Terapan Kimia Vol 6 No 1 (2024): April 2024
Publisher : Department of Chemistry - Universitas Bangka Belitung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33019/jstk.v6i1.4882

Abstract

Quinolones are heterocyclic compounds that are important in medicine and materials for DSSCs or OLEDs. One thing that is rarely studied is the ability to detect metal ions. Diazo groups have an important role in forming complexes with metal ions. This research aims to obtain initial information regarding the metal detection capabilities of diazo quinolinone compounds. The compound 7-[(2,4-dihydroxyphenyl)diazenyl]-4-methyl-2-quinolinone is the test target. Tests were carried out with various metal ions in MeOH. Next, the wavelength of the complex was determined using a UV-Vis spectrophotometer. The results of complex analysis of Compound 2 with various metal ions show the potential to be an indication of the presence of metal ions.
Co-Authors Abdon Saiya Ajeng Triane Syawila Ana Mardliyah Atiqoh Zummah Febrindah Ester Tambalean Jefry Wijaya Mariam Ulfah Marlina Karundeng Paat, Vlagia Indira Robby Gus Mahardika Stefan Marco Rumengan Tengker, Soenandar Millian Tompunu