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All Journal JURNAL KESEHATAN LINGKUNGAN (Journal of Environmental Health) Majalah Obat Tradisional Journal of Islamic Pharmacy BIOTROPIC The Journal of Tropical Biology Jurnal Wiyata : Penelitian Sains dan Kesehatan Jurnal Biologi Tropis AL-HAYAT: Journal of Biology and Applied Biology Jurnal Ilmiah Biologi Eksperimen dan Keanekaragaman Hayati (J-BEKH) Stannum : Jurnal Sains dan Terapan Kimia Spizaetus: Jurnal Biologi dan Pendidikan Biologi Jurnal Jeumpa IJCR (Indonesian Journal of Chemical Research)
Atiqoh Zummah
UIN Sunan Ampel Surabaya
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences Other

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PENGUJIAN FITOKIMIA DAN PENENTUAN PARAMETER KINETIK ENZIM DENGAN PENAMBAHAN EKSTRAK INFUSA AIR SELEDRI Rahma Diyan Martha; Atiqoh Zummah
Jurnal Wiyata Penelitian Sains dan Kesehatan Vol 5, No 2 (2018)
Publisher : LP2M IIK (Lembaga Penelitian dan Pengabdian Masyarakat Institut Ilmu Kesehatan) Bhakti Wiy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (325.47 KB)

Abstract

Latar belakang: Hiperurisemia merupakan kelainan metabolisme karena produksi asam urat yang berlebih. Prevalensi hiperurisemia di Indonesia diperkirakan antara 2,3-17,6%, sehingga penelitian mengenai obat antihiperuresemia sangat dibutuhkan saat ini. Tujuan: untuk mengetahui aktivitas infusa batang seledri terhadap parameter kinetic enzim xantin oksidase. Metode: spektrofotometri UV untuk mengukur kadar asam urat. Hasil: pengujian kandungan senyawa bahan aktif menunjukkan hasil positif pada pengujian flavonoid. Parameter kinetik enzim Km dan Vmaks menunjukkan perubahan nilai dengan adanya penambahan infusa batang seledri. Nilai Km enzim adalah sebesar 90,00 ppm, dan nilai Vmaks enzim sebesar 3,51 U/mL sebelum adanya penambahan ekstrak air batang seledri dan nilai Km dan Vmaks berubah menjadi 125,42 ppm dan 2,97 U/mL dengan adanya penambahan ekstrak infusa air batang seledri. Simpulan dan saran: pengujian kandungan senyawa bahan aktif menunjukkan hasil positif pada pengujian flavonoid, sedangkan uji parameter kinetik enzim menunjukkan kenaikan Km dan Vmaks menunjukkan penurunan  dengan adanya penambahan ekstrak infusa air batang seledri.
PENENTUAN PARAMETER KINETIK ENZIM XANTIN OKSIDASE TERINHIBISI EKSTRAK SELEDRI BERDASARKAN METODE GRAFIK LINEWEAVER-BURK DAN LANGMUIR ATIQOH ZUMMAH; RAHMA DIYAN MARTHA
Jurnal Wiyata Penelitian Sains dan Kesehatan Vol 7, No 1 (2020)
Publisher : LP2M IIK (Lembaga Penelitian dan Pengabdian Masyarakat Institut Ilmu Kesehatan) Bhakti Wiy

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Abstract

Latar belakang: Seledri merupakan tanaman obat yang diketahui mampu menghambat aktivitas enzim xantin oksidase yang berperan dalam pembentukan asam urat. Prevalensi penyakit asam urat (gout) yang tinggi di Indonesia, yaitu 1,6-13,6% per seribu penduduk membuat penelitian tentang sifat penghambatan terbentuknya produk asam urat dalam tubuh sangat diperlukan. Tujuan: mengetahui nilai parameter kinetik enzim xantin oksidase dengan adanya penambahan ekstrak seledri. Metode: Ekstrak seledri dari daun dan batang diperoleh menggunakan metode soxhletasi dan pelarut hidroetanol. Penentuan parameter kinetik enzim dilakukan dengan metode grafik linear Lineweaver-Burk dan Langmuir. Hasil: Ekstrak hidroetanol daun seledri menunjukkan inhibisi terbaik sebesar 86.86% (konsentrasi 30%) dan ekstrak hidroetanol batang seledri menunjukkan inhibisi terbaik sebesar 87.71% (konsentrasi 40%). Penambahan ekstrak daun seledri pada enzim memberikan nilai Km sebesar 27.74 ppm dan Vmaks sebesar 3,55 U/mL pada metode grafik Lineweaver-Burk, sedangkan pada metode grafik Langmuir nilai Km mencapai 327.66 ppm dan Vmax sebesar 6.45 U/mL. Penambahan ekstrak batang seledri menghasilkan nilai Km sebesar 145.24 ppm dan Vmax sebesar 4,55 U/mL pada metode grafik Lineweaver-Burk, sementara pada metode grafik Langmuir nilai Km sebesar 321,09 ppm dan Vmaks sebesar 5.21 U/mL. Kesimpulan: Metode grafik Langmuir lebih sesuai digunakan untuk penentuan parameter kinetik dalam inhibisi enzim xantin oksidase oleh ekstrak seledri.
Antihyperurisemic Activity of Aqueous Celery Infusion by Xanthine Oxidase Enzyme Inhibition Atiqoh Zummah; Rahma Diyan Martha
Majalah Obat Tradisional Vol 23, No 3 (2018)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (18.388 KB) | DOI: 10.22146/mot.38500

Abstract

Hyperuricemia is a metabolic disorder because of excessive uric acid production. The high prevalence of hyperuresemia in the world, especially in Indonesia makes the research of antihyperurisemia drugs very needed today. The purpose of this study was to determine the activity of water infusion extract from celery stems and leaves to inhibited xanthine oxidase enzyme. Xanthine oxidase enzyme plays a role in change of hypoxanthine to xanthine and then becomes uric acid. The activity of xanthine oxidase enzyme was determined by UV spectrophotometry method and using xanthine substrate. Absorption at 290 nm indicates the presence of a uric acid product from xanthine oxidation by the xanthine oxidase enzyme. Infused extract which has the smallest absorption at 290 nm showed a better inhibitory ability of the xanthine oxidase enzyme because the change of xanthine substrate to uric acid is inhibited. The result showed the celery stems water infusion extract had better inhibition activity than celery leaves water infusion extract. The best inhibition percentage of celery stems water infusion was 90,25%, while the celery leaves water infusion was 69.07% both of at 20% concentration. The type inhibition of celery stems water infusion extract to xanthine oxidase enzyme showed an uncompetitive inhibition type because showed change in Km and Vmax values. Km and Vmax values before the addition of water infusion of celery stems were 104.33 ppm and 3.83 U/mL respectively changed to 74.49 ppm and 2.69 U/mL after the addition of extract.
Identification of Microplastics Content in Sediment, Water and Digestive Channel of Milkfish (Chanos chanos) in Sidoarjo Pond Annisa Inda Sanabila; Moch Irfan Hadi; Atiqoh Zummah
Al-Hayat: Journal of Biology and Applied Biology Vol 5, No 1 (2022)
Publisher : Fakultas Sains dan Teknologi, UIN Walisongo Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21580/ah.v5i1.12295

Abstract

Microplastics are a form of new pollution that the Indonesian people are not aware of. The factors for the entry of microplastics into pond waters are water sources, anthropogenic activities, and pond cleanliness. The purpose of this study was to determine the abundance of microplastics, the color and shape of microplastics, and the types of microplastic polymers found in sediment, water, and the digestive tract of milkfish (Chanos chanos) in Sidoarjo ponds. The average abundance of microplastics in sediment samples obtained from semi-intensive ponds is 300 particles per 50 grams, while the sediment samples from traditional ponds are 613 particles per 50 grams. The average abundance of microplastics in the semi-intensive pond water samples was 2.1 particles per 20 liters and in traditional ponds was 2.3 particles per 20 liters. The average abundance of microplastics in the milkfish (Chanos chanos) samples from the Semi-Intensive Pond was as many as 6 particles per tail, while the Traditional Pond had 9.5 particles per tail. In this study, four colors of microplastics were found, namely blue, black, red, and transparent, while the microplastics obtained were fiber, fragment, and filament. The types of microplastic polymers encountered in this study were dominated by polyamide or nylon polymers. In sediment samples from both ponds, we found the presence of Polyamide or Nylon polymers, namely Polystyrene and Polyamide or Nylon, and in the digestive tract of milkfish (Chanos chanos), namely Polyamide or Nylon.
Penentuan Tipe Inhibisi Senyawa Analog Kurkumin CA2 terhadap Enzim α-Glukosidase dari Beras Lapuk Atiqoh Zummah; Endang Astuti; Bambang Purwono
Biotropic : The Journal of Tropical Biology Vol. 7 No. 2 (2023): Biotropic, Volume 7 Nomor 2, 2023
Publisher : Program Studi Biologi, Fakultas Sains dan Teknologi, Universitas Islam Negeri Sunan Ampel Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29080/biotropic.v7i2.1952

Abstract

Diabetes is a health problem that exists throughout the world, especially in Indonesia. Based on data compiled from the International Diabetes Federation (IDF) in 2017, people with diabetes in Indonesia reached 10.3 million people, and if not handled properly it is suspected that there will be an increase to 21.3 million people in 2030. Curcumin analog compounds can used for the treatment of diabetes by inhibiting the enzyme α-glucosidase. The curcumin analog compound used in this study was synthesized from 4 methoxybenzaldehyde with cyclopentanone which was then called the CA2 compound. The α-glucosidase enzyme used in this study was obtained through extraction of weathered rice with an optimum pH of 4.5 and the enzyme extract fraction used was fraction II which had the highest activity compared to fractions I and III. The results showed that the values of the kinetic parameters Km and Vmax of the extracted α-glucosidase enzyme were 1.53 mM and 0.03 U/mL, respectively. The Km kinetic parameter value changed to 1.66 Mm while the Vmax value did not change when the α-glucosidase enzyme was inhibited by CA2 compound, so that the type of inhibition shown by CA2 compound was competitive.
Pengendalian Hama Bemisia tabaci pada Tanaman Melon Varietas Golden Langkawi melalui Modifikasi Warna dan Ketinggian Perangkap Nurriza Dwi Dellita Sari; Saiful Bahri; Eko Teguh Pribadi; Abdul Manan; Atiqoh Zummah
Spizaetus: Jurnal Biologi dan Pendidikan Biologi Vol 5 No 2 (2024): Spizaetus: Jurnal Biologi dan Pendidikan Biologi
Publisher : Program Studi Pendidikan Biologi, FKIP, Universitas Nusa Nipa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55241/spibio.v5i2.379

Abstract

Buah melon (Cucumis melo L.) kaya nutrisi, namun produksinya rentan terhadap serangan hama seperti kutu kebul. Penggunaan perangkap likat menjadi solusi alternatif untuk mengendalikan hama tersebut tanpa terlalu mengandalkan insektisida sintetik. Penelitian ini secara mendalam mengevaluasi tingkat kerusakan yang ditimbulkan oleh serangan hama kutu kebul (Bemisia tabaci) terhadap tanaman melon, sekaligus menguji efektivitas perangkap lengket dengan memvariasikan warna (hijau, kuning, coklat, putih) dan tinggi (antara 50 hingga 200 cm). Eksperimen dilakukan di dalam rumah kaca dengan menerapkan Rancangan Acak Lengkap faktorial karena kondisi lingkungan yang tidak seragam. Hasil penelitian menunjukkan bahwa perangkap lengket berwarna kuning mampu secara efisien mengurangi populasi kutu kebul hingga mencapai 6.307 individu. Meskipun demikian, penyesuaian tinggi perangkap tidak memberikan pengaruh signifikan (Sig=0,061) terhadap pengurangan populasi kutu kebul, namun tinggi perangkap ternyata dipengaruhi oleh pertumbuhan tanaman. Meskipun perangkap kuning terbukti efektif dalam lingkungan yang seragam, analisis Two-Way ANOVA mengungkap nilai Signifikansi yang menunjukkan hasil yang lebih kompleks. Variabel abiotik seperti iklim, cahaya, dan kelembapan ternyata memegang peran penting dalam memengaruhi efikasi perangkap. Penelitian ini memberikan wawasan mendalam tentang strategi pemilihan perangkap lengket untuk mengendalikan populasi kutu kebul pada tanaman melon, sambil menyoroti pentingnya mempertimbangkan faktor lingkungan dalam pengembangan strategi pengendalian hama yang efektif.
Identifikasi Mikroplastik pada Air, Sedimen, dan Ikan Nila (Oreochromis niloticus) di Sungai Porong, Kabupaten Sidoarjo, Jawa Timur Seftianingrum, Bella; Hidayati, Irul; Zummah, Atiqoh
Jurnal Jeumpa Vol 10 No 1 (2023): Jurnal Jeumpa
Publisher : Department of Biology Education, Faculty of Teacher Training and Education, Samudra University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33059/jj.v10i1.7408

Abstract

Kondisi perairan Indonesia saat ini sangat terancam pencemaran mikroplastik, baik itu air laut meupun air tawar. Adanya cemaran mikroplastik di badan perairan dapat menyebabkan gangguan fisiologi organisme yang hidup diperairan tersebut. Oleh karena itu, penelitian ini dilakukan untuk mengetahui kelimpahan mikroplastik di air, sedimen, dan ikan nila (Oreochromis niloticus) sepanjang hulu, tengah, dan hilir Sungai Porong di Kabupaten Sidoarjo serta menguji bentuk, warna, dan jenis polimer mikroplastik tersebut. Penelitian ini dilakukan dengan metode observasional analitik tanpa melibatkan intervensi pada subjek penelitian, dengan pendekatan retrospektif. Hasil penelitian menunjukkan bahwa Sungai Porong di Kabupaten Sidoarjo, Jawa Timur tercemar oleh mikroplastik, baik pada air, sedimen, maupun organisme (ikan). Bentuk yang paling umum adalah fiber dan warna yang ditemukan adalah hitam, merah, biru, kuning, dan putih. Hasil uji FTIR ATR menunjukkan bahwa mikroplastik yang ditemukan terbuat dari jenis polimer Polymethyl methacrylate acrylic (PMMA), High Density Polyethylene (HDPE), Cellulose Acetate (CA), dan Polyethylene terephthalate (PET). Oleh karena itu, perlu tindakan untuk mengurangi dampak mikroplastik pada lingkungan, seperti dengan mengurangi penggunaan plastik sekali pakai dan meningkatkan sistem pengolahan limbah yang lebih baik.
In Silico Study of Pomegranate Peel Polyphenols as Breast Anticancer Khoirotul Ummah; Atiqoh Zummah
Stannum : Jurnal Sains dan Terapan Kimia Vol 6 No 1 (2024): April 2024
Publisher : Department of Chemistry - Universitas Bangka Belitung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33019/jstk.v6i1.4817

Abstract

Breast cancer is one of the causes of women’s death. Estrogen-α receptors are one of the targets for breast cancer treatment because it plays a role in cancer cell proliferation. Several studies have stated that Flavonoid compounds have high activity in inhibiting the growth of breast cancer cells. This study aims to inhibit polyphenolic compounds in pomegranate peel (gallic acid, cafeic acid, ellagic acid, and chlorogenic acid) against estrogen receptors-α through molecular docking. The 3D structures of the polyphenolic compounds were obtained from the PubChem database and the estrogen-α receptors from the Protein Data Base. Molecular docking simulations were carried out using AutoDock Vina and supporting software such as Biovia Discovery Studio Client 4.1, AutoDockTools 1.5.6, PyMOL, and LigPlot. The results showed that the four polyphenolic compounds had a better potential to inhibit estrogen-α receptors than tamoxifen. The inhibitory potential is evidenced by the low affinity of ligand-protein binding energy (approximately -5.4 to -9.0 kcal/mol). The phenol group of polyphenolic compounds can strengthen the ligand-protein interactions through hydrogen bonds with the active site of ER-ꭤ proteins. Hydrophobic and π-π stacking interactions between polyphenolic and the active site of proteins also support the inhibition potential of polyphenolic compounds. The conclusion is that the polyphenolic compounds in pomegranate peel have the potential as breast anticancers.
Eco-enzyme from Orange Peel as a Key Ingredient in Anti Acne Peel-off Gel Mask Zummah, Atiqoh; Bahri, Saiful; Violando, Wiga Alif; Tyastirin, Esti
Jurnal Ilmiah Biologi Eksperimen dan Keanekaragaman Hayati (J-BEKH) Vol. 11 No. 2 (2024)
Publisher : Department of Biology Faculty of Mathematics and Natural Sciences Universitas Lampung in collaboration with The Indonesian Association of Biology (PBI) Lampung Branch.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jbekh.v11i2.387

Abstract

This study aims to develop a peel-off gel mask formulated from orange peel eco-enzyme solution and its physical characteristics and antibacterial activity against Staphylococcus epidermidis. The resulting gel mask has organoleptic characteristics of transparent brownish color, thick gel consistency, and fresh sour-sweet aroma. Physical characteristic tests showed that the gel mask meets pharmaceutical requirements, namely: pH value 4.5-6.5, spreadability 5-7 cm, and drying time 15-30 minutes. The mask showed good homogeneity without aggregates, although it was a little difficult to peel off, but it was not easily torn, and had stable thermodynamic stability. Antibacterial tests revealed that the peel-off gel mask made from orange peel eco-enzyme was effective in inhibiting the growth of Staphylococcus epidermidis. The diameters of the inhibition zones of the P1, P2, and P3 masks were 2.5 ± 0.5 mm, 2.1 ± 0.35 mm, and 1.5 ± 0.5 mm, respectively. These results indicate the potential of eco-enzymes from orange peel as active ingredients for peel-off gel mask formulation for skin care, especially in inhibiting acne-causing bacteria.
Pengukuran Nilai pH Dan Kadar BOD (Biological Oxygen Demand) di Telaga Belahan Rejo Sebagai Pemantauan Kualitas Air Di Kabupaten Gresik Sa'adah, Nafiatus; Zummah, Atiqoh; Teguh Pribadi, Eko; Safarina, Nourma
INDONESIAN JOURNAL OF CHEMICAL RESEARCH Vol. 9 No. 2 (2024): Volume 9, ISSUE 2,2024
Publisher : Chemistry Department, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/ijcr.vol9.iss2.art8

Abstract

Belahan Rejo Lake is one of the water bodies in Gresik Regency. Belahan Rejo lake water is used by the surrounding community for daily purposes such as irrigation of rice fields, plantations, fisheries, domestic, and so on. Activities carried out by the community around Belahan Rejo lake can affect water quality and can even cause water pollution. The purpose of this study is to determine the quality of Belahan Rejo lake water in terms of pH and BOD (Biological Oxygen Demand) parameters. Analysis of pH values is carried out based on the SNI 6989.11: 2019 method using a pH meter tool while analysis of BOD levels is carried out based on the SNI 6989.72: 2009 method by looking at the value of dissolved oxygen using a DO meter tool. The results of the analysis show that Telaga Water in Belahan Rejo Hamlet, Gresik Regency is in accordance with quality standards with a pH value of 6.5 and Biological Oxygen Demand (BOD) levels of 5.1 mg/L.
Co-Authors Abdul Manan Ainida, Anya Hayyu Andini, Eka Andini San Putri Annisa Inda Sanabila Bambang Purwono Eko Teguh Pribadi Endang Astuti Esti Tyastirin Irul Hidayati Khoirotul Ummah Moch. Irfan Hadi Mukhaimin, Iman Nur Maulida Safitri Nurriza Dwi Dellita Sari Prima Retno Wikandari Puspitasari, Asthervina Widyastami Rahma Diyan Martha Rahmah, Firda Maghfiratur Ramli, Taufik Hadi Rani, Titis Eka Rizkiah, Riza Sa'adah, Nafiatus Safarina, Nourma Saiful Bahri Saiful Bahri Sanabila, Annisa Inda Seftianingrum, Bella Suhardi, Haidar Rafli Putra Suhermanto, Achmad Violando, Wiga Alif Zahro, Dea Ma'rifatul