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All Journal Jurnal Ilmiah PANNMED (Pharmacist, Analyst, Nurse, Nutrition, Midwivery, Environment, Dentist) Jurnal Farmasetis
Ardy Tanfil. T
STIKes Prima Indonesia
Education Health Professions Medicine & Pharmacology Nursing Public Health

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ALKALOID : GOLONGAN SENYAWA DENGAN SEGUDANG MANFAAT FARMAKOLOGIS Ardy Tanfil. T; Wiwin Alfianna; Ing Mayfa Br Situmorang
Jurnal Ilmiah PANNMED (Pharmacist, Analyst, Nurse, Nutrition, Midwivery, Environment, Dentist) Vol. 18 No. 1 (2023): Jurnal Ilmiah PANNMED Periode Januari - April 2023
Publisher : Poltekkes Kemenkes Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36911/pannmed.v18i1.1533

Abstract

ABSTRACT Alkaloids are a family of naturally occurring chemicals that can be found in a variety of plants, including certain plants used in medicine. They have been used in various forms of traditional medicine for thousands of years and are known to have a wide range of pharmacological effects on the human body. It has been shown that alkaloids may have potential therapeutic effects for various diseases and ailments. However, their use can also be associated with various side effects, and as a result, it is important to be careful when using them. This article presents many studies investigating the impact of alkaloids on living organisms. Keywords: Alkaloids, Pharmacology, Secondary Metabolites
Modification and Structure Evaluation of Clorogenic Acid Compounds as BACE1 Inhibitors for the Treatment of Alzheimer Ardy Tanfil. T; Tunas Alam
Jurnal Farmasetis Vol 12 No 4 (2023): Jurnal Farmasetis: November 2023
Publisher : LPPM Sekolah Tinggi Ilmu Kesehatan Kendal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32583/far.v12i4.1337

Abstract

Alzheimer's disease remains an unresolved health issue to this day, mainly due to the limitations and adverse effects of available medications. Alzheimer's is characterized by the accumulation of amyloid plaques formed through the action of the BACE1 enzyme. Chlorogenic acid has shown potential as an Alzheimer's drug candidate due to its diverse neurological benefits. The aim of this research is to develop chlorogenic acid as a BACE1 inhibitor by modifying its molecular structure to enhance its effectiveness. The study employs in silico methods, involving structural modifications of chlorogenic acid and assessing its activity using molecular docking. The research employs in silico approaches to modify the structure of chlorogenic acid and analyze the interactions of the resulting compounds with BACE1 through molecular docking. The modified compounds demonstrate improved potential as BACE1 inhibitors as they can directly bind to the amino acid residues ASP A:32 and ASP A:228 on BACE1. Chlorogenic acid's structure can be modified to yield novel compounds with the potential to inhibit BACE1, offering a promising solution for Alzheimer's treatment. This study provides valuable insights for the development of more effective and safer Alzheimer's drugs.
Co-Authors Ing Mayfa Br Situmorang Tunas Alam Wiwin Alfianna