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All Journal JURNAL KIMIA SAINS DAN APLIKASI Pharmaciana: Jurnal Kefarmasian Jurnal Farmasi Indonesia ALKIMIA : Jurnal Ilmu Kimia dan Terapan Jurnal Farmasetis Jurnal Kefarmasian Indonesia
Tunas Alam
Department Of Pharmacy, STIKes Prima Indonesia
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Engineering Environmental Science Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences

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Aktivitas Antioksidan Ekstrak Etanol Dan Fraksi Ciplukan (Physalis angulata) Pada DPPH (1,1-difenil-2-pikrihidrazil) Tunas Alam; Meiliza Ekayanti; Nada Permana; Zulfikar Hadissabil
Jurnal Farmasi Indonesia Vol 19 No 1 (2022): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v19i1.1490

Abstract

Antioksidan eksogen pada tanaman diketahui memiliki efek samping yang kecil, murah dan digunakan dalam mencegah penyakit. Dengan berkembangnya penggunaan tanaman dan sayuran sebagai sumber antioksidan alami, banyak peneliti tertarik untuk menginvestigasi dan mempelajari hal ini. Dalam penelitian ini, ekstrak etanol dan fraksi tanaman ciplukan (Physalis angulata) dilakukan investigasi dan evaluasi potensi aktivitas antioksidannya. Fokus dari penelitian ini adalah menetapkan kadar dan mengevaluasi aktivitas antioksidan dari ekstrak etanol dan fraksi ciplukan. Akar, batang, dan daun ciplukan diekstraksi dengan menggunakan metode maserasi kemudian dipartisi dengan fraksi polar (air), non polar (n-heksana), dan semipolar (etil asetat). Hasil ekstraksi kemudian dianalisis kadar flavonoid total dengan menggunakan kuersetin sebagai standar dan aktivitas antioksidan pada DPPH. Hubungan antara kadar total flavonoid dan aktivitas antioksidan ditentukan dengan metode regresi linier. Ekstrak etanol daun ciplukan memiliki nilai total flavonoid tertinggi yaitu 38.04 ± 0.8 mg/g kemudian diikuti oleh ekstrak akar (9 ± 0.2 mg/g), dan ekstrak batang (7.1 ± 0.1 mg/g). Fraksi etil asetat dari ekstrak etanol daun ciplukan memiliki aktivitas antioksidan yang tinggi yaitu 32.10 ± 0.2 µg/ml yang dihitung sebagai IC50 kemudian diikuti oleh fraksi air (38.20 ± 0.8 µg/ml), dan fraksi heksana (38.20 ± 0.8 µg/ml) . Hasil analisis regresi linier menunjukkan aktivitas antioksidan berkorelasi dengan nilai total flavonoid dan disimpulkan bahwa flavonoid merupakan komponen antioksidan utama pada tanaman ciplukan.
Determination of Heavy Metals and Other Toxic Elements In Four Brands of Commercial Bottled Water From Indonesia Market By ICP/MS Alam, Tunas
ALKIMIA Vol 5 No 1 (2021): ALKIMIA
Publisher : SCIENCE AND TECHNOLOGY FACULTY OF UNIVERSITAS ISLAM NEGERI RADEN FATAH PALEMBANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (679.003 KB) | DOI: 10.19109/alkimia.v5i1.10588

Abstract

Heavy metals and toxic elements four brands of commercial bottled water from Indonesia market were analyzed by using Inductive Couple Plasma-Mass Spectrometer (ICP-MS). The heavy metals and toxic elements to be analyzed were copper (Cu), iron (Fe), lead (Pb), cadmium (Cd), chromium (Cr), arsenic (As), selenium (Se) and manganese (Mn). The results are the heavy metals and toxic elements from all commercial water samples were below the permissible level of the World Health Organization (WHO) and Standar Nasional Indonesia (SNI). Hence, this determination clarify no risk about quality and safety of commercial bottled water for public drinking water.
Tyrosinase Inhibitory of Silver Nanoparticles Synthesized using Morus Nigra Leaves Extract Tunas Alam; Ricky Ardiansyah; Sharfina Maulidayanti; Deva Azvara; Frida Octavia Purnomo; Dicky Annas
Jurnal Kimia Sains dan Aplikasi Vol 26, No 3 (2023): Volume 26 Issue 3 Year 2023
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.26.3.85-90

Abstract

A novel preparation of silver nanoparticles using Morus nigra leaves extract, as opposed to the physical and chemical methods had been used in this work. Their active phytochemical compounds will reduce Ag+ and form AgNPs (Ag0). A peak spectrum at 460 nm was formed and confirmed as the Surface Plasmon Resonance (SPR). Vibration at 1643 cm-1 and 3286 cm-1 which characteristic of C=C bonds and (-OH) hydroxyl groups, respectively. An X-ray diffraction (XRD) examination of silver with good crystallinity revealed its distinctive pattern. According to the results of transmission electron microscopy (TEM), the produced AgNPs-Morus nigra leaves extract were between 10 and 20 nm in size. Using L-dihydroxyphenylalanine (L-DOPA) as the substrate, the synthesized AgNPs-Morus nigra were tested for their tyrosinase inhibitory activity, and the results are substantial when compared to kojic acid as a control. The percentages of inhibition from crude extract, AgNPs, and kojic acid at 100 µg/mL are to be found at 12.10 %, 64.80 %, and 59.84 %, respectively. Based on the results of this work, AgNPs can be produced by utilizing a green synthesis method with leaves extract, making them a promising candidate for use in medicine and cosmetics.
Modification and Structure Evaluation of Clorogenic Acid Compounds as BACE1 Inhibitors for the Treatment of Alzheimer Ardy Tanfil. T; Tunas Alam
Jurnal Farmasetis Vol 12 No 4 (2023): Jurnal Farmasetis: November 2023
Publisher : LPPM Sekolah Tinggi Ilmu Kesehatan Kendal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32583/far.v12i4.1337

Abstract

Alzheimer's disease remains an unresolved health issue to this day, mainly due to the limitations and adverse effects of available medications. Alzheimer's is characterized by the accumulation of amyloid plaques formed through the action of the BACE1 enzyme. Chlorogenic acid has shown potential as an Alzheimer's drug candidate due to its diverse neurological benefits. The aim of this research is to develop chlorogenic acid as a BACE1 inhibitor by modifying its molecular structure to enhance its effectiveness. The study employs in silico methods, involving structural modifications of chlorogenic acid and assessing its activity using molecular docking. The research employs in silico approaches to modify the structure of chlorogenic acid and analyze the interactions of the resulting compounds with BACE1 through molecular docking. The modified compounds demonstrate improved potential as BACE1 inhibitors as they can directly bind to the amino acid residues ASP A:32 and ASP A:228 on BACE1. Chlorogenic acid's structure can be modified to yield novel compounds with the potential to inhibit BACE1, offering a promising solution for Alzheimer's treatment. This study provides valuable insights for the development of more effective and safer Alzheimer's drugs.
Antimicrobial Activities of Synthesized Silver Nanoparticles using Ethanol and Water Extract of Mirabilis Jalapa Tunas Alam; Frida Octavia Purnomo; Asbar Tanjung
Jurnal Kimia Sains dan Aplikasi Vol 24, No 3 (2021): Volume 24 Issue 3 Year 2021
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (3116.302 KB) | DOI: 10.14710/jksa.24.3.70-76

Abstract

The focus of this study was to compare the antimicrobial activity of silver nanoparticles (AgNPs) synthesized using ethanol extracts (AgNPE) and water extracts (AgNPA) from four o’clock flowers (Mirabilis jalapa) against Staphylococcus aureus. AgNPs were characterized by UV-Vis diffraction, FTIR, SEM, and X-rays. UV-Vis analysis showed that AgNPA has an SPR band of about 460 nm and 530 nm for AgNPE, which proves the characteristics of the absorbance area of AgNPs. SEM images of AgNPE and AgNPA show a cuboid shape with a mean diameter of 80 and 30 nm, respectively and well dispersed. The response to the presence of polysaccharide biomolecules involved in forming AgNPs was analyzed using a Fourier transform infrared spectrometer. The result was that AgNPA and AgNPE have different reducing agents. The plant extracts, AgNPE and AgNPA, were studied for their antimicrobial activity against Staphylococcus aureus. The result was that both AgNPA and AgNPE showed good activity and showed that AgNPA with less inhibition was more effective than AgNPE.
Study of kinetic and adsorption isotherm of ibuprofen on mcm-41 synthesized with rice husk Hartono, Olyvia Azzahra Putri; Purnomo, Frida Octavia; Waluyo, Dyah Ayuwati; Alam, Tunas; Madiabu, Mohammad Jihad
Pharmaciana Vol. 14 No. 2 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i2.27393

Abstract

Rice husk is one of the abundant wastes, especially in agricultural countries. Rice husk waste has asilica content of 95.80%, where the silica content can be utilized to make an adsorbent. One of theadsorbents that can be made is Mobil Composition of Matter 41 (MCM-41), a material with ahexagonal structure with a surface area to adsorb ibuprofen. Based on the results of the research thathas been done, MCM-41 synthesized with rice husk has the same characterization results as MCM-41synthesized with commercial materials tetraethyl orthosilicate (TEOS). Fourier Transform InfraredSpectroscopy (FTIR) characterization results show the absorption peak is at wave number 1068.58 cm1 which shows asymmetric Si-O-Si stretching vibrations and at 799.60 cm-1region is symmetric Si-OSi stretching vibrations. X-ray diffraction (XRD) characterization results show an hexagonal crystalform at 20 = 20o-30o. Scanning Electron Microscope (SEM) characterization results show particle of2,664 um. Based on the results of the research that has been done MCM-41 synthesized from rice huskcan adsorb ibuprofen with Langmuir isotherm approach and Pseudo Second Order kinetics, and themaximum adsorbing capacity is 34.48 mg/g
Uji Aktivitas Sitotoksik Ekstrak Polar, Semipolar, dan Non-Polar Daun Sambiloto (Andrographis paniculata) terhadap Sel Kanker Hati (HepG2) Shofa, Andzar Fikranus; Alam, Tunas; Nuralih, Nuralih
Jurnal Kefarmasian Indonesia VOLUME 12, NOMOR 1, FEBRUARI 2022
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v0i0.4875

Abstract

Cancer is one of the causes of 6 major deaths in the world besides HIV, malaria, and tuberculosis. The incidence of liver cancer cases in 2018 reached 841 thousand, where there were 782 deaths. Modern medicine such as surgery, radiation, and chemotherapy has various drawbacks, high side effects, therapeutics failure, and high costs. Therefore, WHO recommends herbal medicine as a complementary therapy for various diseases, one of which is cancer. Sambiloto is one of the herbal plants that has been widely used by the people of Indonesia. The potential efficacy of sambiloto as a prospective herbal plant has been widely proven both through in vitro and in vivo studies. This study aims to determine the cytotoxic activity and IC50 value of polar, semipolar, and non-polar fractions of sambiloto leaves on HepG2 cells. Each fraction was tested for its cytotoxic activity against HepG2 cells with a concentration of 500; 250; 125; 62.5; 31.25; and 15,625 µg/mL using the MTT method. The results showed that the IC50 value for the polar, semipolar, and non-polar fractions was 82.585; 53,154; 614,349 µg / mL. Based on these results, the ethyl acetate and ethanol fractions of sambiloto leaves had strong cytotoxic activity against HepG2 cells.
Analisis Flavonoid Total dan Aktivitas Antioksidan Fraksi Etanol Kulit Semangka (Citrullus lanatus) Feronika Evma Rahayu; Dede Irma Hidayat; Tunas Alam
Jurnal Farmasi Indonesia Vol 21 No 2 (2024): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v21i2.1888

Abstract

Antioxidants are required to keep the body's defenses against free radicals intact. Watermelon rind (Citrullus lanatus (Thunb). & Nakai) contains phenolic compounds which are included in the flavonoid group and can act as natural antioxidant compounds. This study evaluated watermelon rind (Citrullus lanatus (Thunb). & Nakai) for its antioxidant activity. The dried watermelon rind (Citrullus lanatus (Thunb). & Nakai) was extracted using the maceration method and then partitioned into polar (water), non-polar (n-hexane), and semi-polar (ethyl acetate) fractions. Following extraction, the study's methodology is briefly outlined in the second paragraph and is in line with the findings of this publication. The highest total flavonoid value was found in the watermelon rind (Citrullus lanatus (Thunb). & Nakai) ethanol extract, which measured 49.6 mg/g in the ethyl acetate fraction, 48.6 mg/g in the water fraction, and12.05 mg/g in the n-hexane fraction. The ethyl acetate fraction has strong antioxidant activity (55.36), followed by the water fraction (71.25), and the n-hexane is not strong (225.59).
Co-Authors Andzar Fikranus Shofa Ardy Tanfil. T Asbar Tanjung Dede Irma Hidayat Deva Azvara Dicky Annas Dyah Ayuwati Waluyo Feronika Evma Rahayu Frida Octavia Purnomo Hartono, Olyvia Azzahra Putri Madiabu, Mohammad Jihad Meiliza Ekayanti Nada Permana Nuralih Nuralih Nuralih Nuralih, Nuralih Ricky Ardiansyah Sharfina Maulidayanti Shofa, Andzar Fikranus Zulfikar Hadissabil