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All Journal Jurnal Ilmiah Medicamento Eduvest - Journal of Universal Studies
Puguh Santoso
Universitas Mahasaraswati Denpasar
Aerospace Engineering Computer Science & IT Health Professions Medicine & Pharmacology Neuroscience Public Health Social Sciences

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Uji Iritasi dan Aktivitas Penumbuh Rambut Hair Tonic dari Tanaman Usada Bali pada Mencit Putu Era Sandhi Kusuma Yuda; Puguh Santoso; Erna Cahyaningsih; Gusti Ayu Made Indah Siantari
Jurnal Ilmiah Medicamento Vol 9 No 1 (2023): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v9i1.5502

Abstract

The existence of side effects from drugs used for hair loss treatment urges the need for safer alternatives, especially from natural ingredients. The purpose of this study was to determine the effectiveness and safety of hair tonic from Usada Bali (containing Polycias scutellaria, Hibiscus tiliaceus, Trigonella foenum graecum, and Cananga odorata) in mice. Experimental animals were divided into four groups: negative control was given a carrier fluid, positive control was given hair tonic on the market, and the treatment group was given hair tonic with simplicia concentration of 10% and 20%. Hair length was measured on days 7 and 21 with the treatment given daily topically on the backs of shaved mice. The irritation test was carried out at 24 and 48 hours. The data obtained were tested statistically by ANOVA test followed by Tukey's test with 95% confidence level. The results showed that the hair tonic formula contained alkaloids, flavonoids, saponins, tannins and triterpenoids. The irritation test did not show any irritation on the skin of the mice. The hair growth activity test of the herbal hair tonic formula combination of Polycias scutellaria leaf, Hibiscus tiliaceus leaf, Trigonella foenum graecum seed and Cananga odorata flower showed significantly faster hair growth than the negative control at both concentrations and not significantly different from the positive control. This hair tonic formula has the potential to be developed into a natural hair growth agent without irritation to the skin.
The Effect of n-Butanol Extract of Dewandaru Fruit (Eugenia uniflora L.) on the Leukocyte Count in Mice Exposed to Cigarette Smoke Puguh Santoso; Ni Putu Febi Andani
Eduvest - Journal of Universal Studies Vol. 6 No. 5 (2026): Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v6i5.53082

Abstract

Dewandaru (Eugenia uniflora L.) is a medicinal plant that has been widely used in traditional medicine. Cigarettes are addictive substances that pose a significant threat to health and life sustainability. The principal toxic constituents of cigarettes are nicotine, tar, and carbon monoxide (CO). Long-term smoking can increase the total leukocyte count, particularly the number of polymorphonuclear neutrophils (PMN) in the peripheral blood circulation, due to free radical generation and inflammatory reactions. Dewandaru fruit (Eugenia uniflora L.) contains antioxidant and anti-inflammatory compounds that may inhibit leukocyte activation induced by oxidative stress associated with cigarette smoke exposure, thereby contributing to a reduction in the total leukocyte count. This study employed an experimental design with a posttest-only control group, using a sample of 30 male mice (Mus musculus) divided into three groups. Group I served as the negative control and received cigarette smoke exposure and distilled water. Groups II and III were designated as treatment groups and received 30 minutes of cigarette smoke exposure per day for 30 days, along with oral administration of n-butanol extract of dewandaru fruit at doses of 100 mg/kgBW and 200 mg/kgBW, respectively. On day 31, peripheral blood samples were collected from all subjects. The findings of this study indicate that administration of n-butanol extract of dewandaru fruit (Eugenia uniflora L.) resulted in a reduction in the total leukocyte count in male mice receiving the extract compared to the control group.
Co-Authors Erna Cahyaningsih Gusti Ayu Made Indah Siantari Ni Putu Febi Andani Putu Era Sandhi Kusuma Yuda