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All Journal Abdimas Talenta : Jurnal Pengabdian Kepada Masyarakat Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Inke Nadia Diniyanti Lubis, Inke Nadia Diniyanti
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Agriculture, Biological Sciences & Forestry Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences

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Relationship between Vascular Cell Adhesion Molecule-1 (Vcam-1) Level with Severity Degree of COVID-19 Patients at General Hospital H. Adam Malik Medan Elvira; Siregar, Jelita; Lubis, Inke Nadia Diniyanti; Herman Hariman
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 5 No. 4 (2023): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v5i4.14410

Abstract

Background: The mechanism and pathogenesis of COVID-19 that distinguishes asymptomatic, mild, moderate, severe to critical symptoms is not yet known with certainty. Endothelial dysfunction and immune thrombosis serve as a profound pathogenic mechanism in COVID-19. Vascular Cell Adhesion Molecule-1 (VCAM-1) is a major regulator of leukocyte adhesion that contributes to the formation of thrombosis. The purpose of the study determine the relationship between VCAM-1 level with the severity degree in COVID-19 patients. Methods: An analytical study with a cross-sectional design was conducted from September – March 2022. This study was followed by 50 patients aged over 18 years with moderate, severe, and critical degrees of COVID-19 admitted to Haji Adam Malik General Hospital Medan by excluding malignancy and pregnancy patients. Serum VCAM-1 levels were measured using Chemwell Analyzer.  Results: Among 50 patients, 33 patients (66%) were male and 17 patients (34%) were female. The mean age was 57 years with the youngest 19 years old and the oldest 81 years old. The median level of VCAM-1 was 23,02 ng/mL (10.96 ng/mL - 50.63 ng/mL). The median concentration of VCAM-1 was 37.85 ng/mL (15,59 – 50.63), 36.68 ng/mL (19.58 – 49.71), and 18.83 ng/mL (10.96 – 46.32) for critical, severe, and moderate degree respectively (p = 0.001). The cut-off value of VCAM-1 levels to predict the severity of COVID-19 is 32.01 ng/mL. Conclusions: There is a significant relationship between VCAM-1 levels and the severity of COVID-19.
Training On Improving Training On Improving Health Cadres Capacity In Eradication of Tuberculosis Disease In Communities Kusumawati, R Lia; Hasibuan, Mirzan; Lubis, Inke Nadia Diniyanti
ABDIMAS TALENTA: Jurnal Pengabdian Kepada Masyarakat Vol. 5 No. 2 (2020): ABDIMAS TALENTA : Jurnal Pengabdian Kepada Masyarakat
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (146.553 KB) | DOI: 10.32734/abdimastalenta.v5i2.4315

Abstract

Tuberculosis (TB) is an important issue in public health, where Indonesia ranks second in the world after India and China. The discovery of TB suspects and cases through health facilities is very important, this makes the role of health cadres in the community in the discovery of TB suspects in their area. The purpose of this community service activity is to train health cadres in an effort to increase the capacity of knowledge about tuberculosis (TB). Health cadres in the PKK area of ​​Medan Tuntung District have not been exposed to special training in tuberculosis infectious diseases. The results of the training show that there is a significant difference between the knowledge of tuberculosis infectious disease before training (pre-test) compared to after training (post-test) (p value <0.05). The results of the pre-test scores showed that cadre knowledge before training was categorized as good as 12/30 (40%) and cadre knowledge increased after receiving special training on Tuberculosis which was categorized as good at 26/30 (87%).
Co-Authors Elvira Hasibuan, Mirzan Herman Hariman Kusumawati, R Lia Siregar, Jelita