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All Journal Majalah Kedokteran Bandung Indonesian Journal of Medicine Jurnal Respirasi (JR) Jurnal Keperawatan Priority Indonesian Journal of Global Health research Narra J Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) International Journal of Health and Pharmaceutical (IJHP) Reflection Journal The Journal of Society Medicine (JSOCMED) The International Journal of Tropical Veterinary and Biomedical Research
Siregar, Jelita
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Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Differences in MPV (Mean Platelet Volume) / Lymphocytes Ratio In Chronic Hepatitis B with and without Cirrhosis Hepatic Elsha, Elsha Sinulingga; Siregar, Jelita; Sungkar, Taufik
Journal of Society Medicine Vol. 3 No. 6 (2024): June
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/jsocmed.v3i6.151

Abstract

Introduction: The MPV/Lymphocyte Ratio is a simple inflammatory parameter that can be obtained from a complete blood count. Hepatitis patients with liver cirrhosis have a higher MPV causing thrombopoietin to decrease so that the platelet count decreases. The inflammatory response can cause a decrease in the number of lymphocytes and is closely related to a poor prognosis in patients with hepatitis B virus. This study aims to examine the differences in the MPV/Lymphocyte ratio in chronic hepatitis B patients with and without liver cirrhosis. Methods: The samples for this study was chronic hepatitis B patients with and without liver cirrhosis who met he inclusion criteria. The research was carried out by taking blood samples from 94 patients treated in the internal medicine treatment room and Gastroenterohepatology polyclinic at Adam Malik Hospital, Medan. Samples were examined for MPV, absolute lymphocytes, then the MPV/lymphocyte ratio was calculated. Results: The total number of subjects in this study was 94 and there were 62 men and 32 women. The results of the analysis showed that there was a significant difference between the cirrhotic and non-cirrhotic groups (p = 0.001). Conclusion: There was a significant difference in the ratio of MPV/lymphocytes in the group of hepatitis B subjects with cirrhosis and in the group of hepatitis B subjects without liver cirrhosis. (p = 0.001).
Determinants of COVID-19 severity and mortality in children: A retrospective and multicenter cohort study in Medan, Indonesia Airlangga, Eka; Wahyuni, Arlinda S.; Siregar, Jelita; Malisie, Ririe F.; Lubis, Bugis M.; Adisasmito, Wiku B.; Zarlis, Muhammad; Pasaribu, Ayodhia P.
Narra J Vol. 4 No. 2 (2024): August 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i2.865

Abstract

This study investigated indicators of the severity and mortality of COVID-19 in children in Medan, Sumatera Utara Province, Indonesia. The aim of this study was to identify determinants of severity and outcome of children with COVID-19 as the lesson learned from the COVID-19 pandemic, particularly the limited health facilities in Indonesia. This retrospective cohort study was conducted in 2020, 2021, and 2022 at multiple centers. Inpatient and outpatient children confirmed to be SARS-CoV-2 positive were randomly recruited in the selected hospitals. Baseline data (demographic, clinical, laboratory and radiological data) were collected, and outcomes were classified as recovered/deceased (for the inpatient group) or returned to the hospital (for the outpatient group). Severity status was identified based on the Indonesia COVID-19 guidelines. The laboratory data were categorized according to international standards, and data were analyzed using univariate analyzes followed by multivariate logistic regression. A total of 303 inpatient and 114 outpatient children were included in the analysis. Out of the total inpatient cases, 11 patients died with 3.6 mortality rate. Our final multivariate indicated that the presence of shortness of breath (SOB), anemia, and abnormal C-reactive protein (CRP) levels were significantly associated with the severity or the presence of emergency signs, while the presence of SOB and comorbidities were significantly associated with mortality in inpatient children with COVID-19. The presence of fever, cough, SOB, muscle ache and diarrhea were the reasons why the children were returned to the hospital from self-isolation at home among outpatient COVID-19 cases; however, the cough was the only significant factor in the final multivariate mode. This study highlights important determinants of COVID-19 severity and mortality in children, which should be considered during clinical decision-making in low-resource settings of healthcare centers in Indonesia.
Correlation between Apolipoprotein B Levels with Coronary Lesion Area Based on the Gensini Scores in Coronary Heart Disease Patients Siallagan, Delpiana; Siregar, Jelita; Hasan, Refli
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 5 No. 3 (2023): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v5i3.14396

Abstract

Background: Coronary heart disease (CHD) is caused by atherosclerosis. apolipoprotein B (Apo B) is a large glycoprotein, that plays a role in lipoprotein metabolism and human lipid transport, reflecting atherogenic cholesterol transport. The Gensini scoring system has the highest correlation with the severity of coronary artery stenosis as assessed by angiography. This study aims to determine the correlation between apolipoprotein B levels with the area of ​​coronary lesions based on the Gensini score in patients with CHD Methods: This research is an observational study with cross cross-sectional data collection method of 76 coronary heart disease patients who were treated at H. Adam Malik General Hospital Medan (December 2021 – April 2022). Examination of the Apo B value was carried out by the immunoturbidimetry method (Architect). Coronary lesion area calculated from coronary angiography with Gensini score. The research was conducted after obtaining ethical approval and informed consent. Result: There were 57 male subjects (75 %). The mean age of the subjects was 56.17 years with the youngest age being 24 years and the oldest being 77 years. Most of the subjects who experienced STEMI amounted to 38 people (50 %). The mean Apo B level was 89.18 mg/dL. The mean Gensini score was 62.84. By using the Pearson correlation test, it was found that a significant correlation was found between Apo B and Gensini score, r = 0,288 (p = 0.012) Conclusions: There was a significant correlation between the levels of Apo B and coronary artery lesions based on the Gensini score. Apo B examination and Gensini score can be used as a risk assessment of severity in CHD patients. Further research is needed to involve a larger number of coronary heart disease patients.
Relationship between Vascular Cell Adhesion Molecule-1 (Vcam-1) Level with Severity Degree of COVID-19 Patients at General Hospital H. Adam Malik Medan Elvira; Siregar, Jelita; Lubis, Inke Nadia Diniyanti; Herman Hariman
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 5 No. 4 (2023): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v5i4.14410

Abstract

Background: The mechanism and pathogenesis of COVID-19 that distinguishes asymptomatic, mild, moderate, severe to critical symptoms is not yet known with certainty. Endothelial dysfunction and immune thrombosis serve as a profound pathogenic mechanism in COVID-19. Vascular Cell Adhesion Molecule-1 (VCAM-1) is a major regulator of leukocyte adhesion that contributes to the formation of thrombosis. The purpose of the study determine the relationship between VCAM-1 level with the severity degree in COVID-19 patients. Methods: An analytical study with a cross-sectional design was conducted from September – March 2022. This study was followed by 50 patients aged over 18 years with moderate, severe, and critical degrees of COVID-19 admitted to Haji Adam Malik General Hospital Medan by excluding malignancy and pregnancy patients. Serum VCAM-1 levels were measured using Chemwell Analyzer.  Results: Among 50 patients, 33 patients (66%) were male and 17 patients (34%) were female. The mean age was 57 years with the youngest 19 years old and the oldest 81 years old. The median level of VCAM-1 was 23,02 ng/mL (10.96 ng/mL - 50.63 ng/mL). The median concentration of VCAM-1 was 37.85 ng/mL (15,59 – 50.63), 36.68 ng/mL (19.58 – 49.71), and 18.83 ng/mL (10.96 – 46.32) for critical, severe, and moderate degree respectively (p = 0.001). The cut-off value of VCAM-1 levels to predict the severity of COVID-19 is 32.01 ng/mL. Conclusions: There is a significant relationship between VCAM-1 levels and the severity of COVID-19.
RASIO MONOSIT LIMFOSIT SEBAGAI PREDIKTOR KEPARAHAN NEFROPATI DIABETIK PADA PASIEN DIABETES MELITUS TIPE 2 Bernando, Andri; Siregar, Jelita; Syafril, Santi
Jurnal Keperawatan Priority Vol. 6 No. 2 (2023)
Publisher : Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jukep.v6i2.4073

Abstract

Diabetic nephropathy is a complication that often occurs in diabetics. In this disease, there is damage to the kidney filter, known as the glomerulus. Due to glomerular damage, diabetic nephropathy is closely related to the mechanism of inflammation. The Monocyte-Lymphocyte Ratio is a relatively new marker of inflammation. This study aims to explore the significance of the prediction of the Monocyte-Lymphocyte Ratio as a predictor of the severity of diabetic nephropathy in Type 2 Diabetes Mellitus (DMT2) patients at H. Adam Malik Hospital, Medan. The research was conducted using the cross-section method. This study took blood samples from 44 patients with type 2 diabetes mellitus with diabetic nephropathy, 22 patients with macroalbuminuria, and 22 patients with microalbuminuria. Then blood was drawn from the vein, and the Monocyte-Lymphocyte Ratio was assessed in all patients. In this study, the average MLR for all patients was 0.41±0.037. There was a significant difference between MLR values ​​in diabetic nephropathy patients with macroalbuminuria compared to diabetic nephropathy patients with microalbuminuria (p<0.001). The optimal cut-off value of MLR in predicting diabetic nephropathy with macroalbuminuria and microalbuminuria was 0.37 with a specificity of 81.8% and a sensitivity of 81.8%. The MLR value in type 2 diabetic patients with diabetic nephropathy can be used as a prognostic factor for the incidence of microalbuminuria and macroalbuminuria.
Correlation of Hepatocyte Growth Factor Levels with Myopia Degree and Axial Length in Outpatient Myopic Adolescents Aldy, Fithria; Yanni, Gema Nazri; Siregar, Jelita
Majalah Kedokteran Bandung Vol 56, No 1 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v56.3281

Abstract

Myopia is the most common ophthalmic condition worldwide, with an estimated 22.9% of the population or 1.406 billion people affected. Studies of candidate gene-associated refraction abnormalities have also identified several genes that cause vulnerability myopia, including the hepatocyte growth factor (HGF) and  hepatocyte growth factor receptor (MET) genes. The purpose of the study was to analyze the correlation between hepatocyte growth factor (HGF) levels, degrees of myopia, and long axial in adolescents with myopia treated as outpatients in Universitas Sumatera Utara Hospital. This study applied the cross-sectional analytical approach. The inclusion criterion for the participants was patients diagnosed as suffering from myopia by the Ophthalmology Outpatient Clinic of the Universitas Sumatera Utara Hospital. Sampling was performed consecutively with a minimum sample size of 25 patients in control group and 25 patients in the case group. This study revealed that the mean axial length of the right eye in the case group was 23.82 mm, with a significant difference in the axial length between the case and control groups. The mean HGF level in the myopia group was 510.49 ng/mL, which was not significantly different from the mean HGF level in the control or emmetropic group. The HGF levels were highest in the group of subjects with moderate myopia, with an average of 551.87 ng/mL, and differences in HGF levels were identified in different degrees of myopia. Thus, no significant correlation is identified between the HGF levels, axial length, and myopia degree.
Differences In D-Dimer Levels of Moderate And Severe Covid-19 Patients Treated At Hajj Adam Malik Hospital, Medan Hadi, Denny; Siregar, Jelita; Novisari Soeroso, Noni; M. Nafchi, Asgar
International Journal of Health and Pharmaceutical (IJHP) Vol. 5 No. 1 (2025): February 2025 (Indonesia - Turkey - Malaysia - Australia - Iran)
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v5i1.396

Abstract

An outbreak of coronavirus disease 2019 (COVID-19), initially reported in December 2019 in Wuhan, Hubei Province, China, emerged as a mysterious pneumonia caused by the novel β-coronavirus, 2019-nCoV. Among hospitalized COVID-19 patients, elevated D-dimer levels and impaired hemostasis have been commonly observed, often associated with disease severity and mortality. This study aimed to assess differences in D-dimer levels among mild, moderate, and severe COVID-19 patients in a cross-sectional design involving 36 confirmed COVID-19 patients hospitalized at H. Adam Malik General Hospital Medan. Conducted from August to October 2021 at the Departments of Clinical Pathology and Pulmonology and Respiratory Medicine, the study used consecutive sampling. The participants had an average age of 50.92 years, with hypertension and diabetes mellitus being the most common comorbidities. The average D-dimer level was 1324.28 ng/mL (SD = 2360.45 ng/mL), ranging from 100 ng/mL to 13,420 ng/mL. A significant difference in D-dimer levels was observed between patients with moderate and severe COVID-19, highlighting its potential role in evaluating disease progression and severity.
Correlation between HbA1c Levels and Red Distribution Cell Width in Type 2 Diabetes Mellitus Patients Rahma, Hadiyatur; Siregar, Jelita; Syafril, Santi; Ganie, Ratna Akbari; Siregar, Dewi Indah Sari; Ginting, Almaycano
Indonesian Journal of Medicine Vol. 9 No. 1 (2024)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2024.9.1.684

Abstract

Background: HbA1c is used as a parameter for diagnosis and monitoring of diabetes mellitus (DM). Apart from that, HbA1c, red blood cells also experience changes which result in changes in erythrocyte structure and hemodynamic characteristics. The parameter that changes in this case is red cell distribution width (RDW). This study aimed to analyze correlation between HbA1c levels and RDW in type 2 DM patients. Subjects and Method: This a cross sectional study conducted at H. Adam Malik General Central Hospital, Medan, North Sumatera, Indonesia, from December 2022-April 2023. Total sample of 75 type 2 DM patients was selected consecutively. The dependent variable was RDW. The independent variable was HbA1c. Data of RDW and HbA1c were collected from complete blood count test. Data were analyzed using the Spearman correlation. Results: HbA1c was negatively associated with RDW, but it was statistically non-significant (r= -0.08; p= 0.508). Conclusion: HbA1c is negatively associated with RDW, but it is statistically non-significant.   Keywords: diabetes melitus, HbA1c, red cell distribution width
Relationship of Neutrophil Lymphocyte Ratio and Glomerulus Filtration Rate in Diabetic Nephropathy Patients at H. Adam Malik Hospital, Medan, Indonesia Merlin, Asri; Siregar, Jelita; Syafril, Santi
Indonesian Journal of Medicine Vol. 9 No. 1 (2024)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2024.9.1.720

Abstract

Background: Diabetic nephropathy is a serious complication of diabetes mellitus (DM). The neutrophil-lymphocyte ratio is the result of the relative count of neutrophils divided by the relative number of lymphocytes in diabetic nephropathy patients in % units obtained from routine hematology results using EDTA blood samples and measured by flow cytometry with Sysmex XN-1000, glomerular filtration rate was measured according to the Cockroft-Gault formula. This study aimed to determine the relationship between neutrophil lymphocyte ratio (NLR) and glomerular filtration rate in diabetic nephropathy patients. Subjects and Method:  This was a cross sectional study conducted at H. Adam Malik Hospital, Medan, North Sumatera, Indonesia, from November 2022 – January 2023. 30 diabetic nephropathy patients were selected for this study consecutively. The dependent variable was the glomerular filtration rate. The independent variable was the NLR. Blood sample was taken for a complete blood count and creatinine examination. Data were analyzed using the Spearman test. Results: NLR was negatively associated with eGFR in patients with diabetic nephropathy, but it was statistically non significant (r= -0.25; p= 0.186). Conclusion: NLR is negatively associated with eGFR in patients with diabetic nephropathy, but it is statistically non significant.  Keywords: neutrophil lymphocyte ratio, glomerular filtration rate, diabetic nephropathy
Corelation Between Uric Acid and Neutrophil Lymphocyte Ratio (NLR) in Controlled and Uncontrolled Type 2 Diabetes Mellitus Situmorang, Immanuel; Siregar, Jelita; Syafril, Santi
Indonesian Journal of Global Health Research Vol 7 No 5 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i5.6986

Abstract

Type 2 diabetes mellitus (DM) is a metabolic disease characterized by chronic hyperglycemia, often linked to metabolic complications and inflammatory conditions. Uric acid and Neutrophil-Lymphocyte Ratio (NLR) are biomarkers of inflammation and oxidative stress in this condition. This study aims to examine the relationship between uric acid and NLR in controlled and uncontrolled type 2 DM patients. Using an analytical observational design with a cross-sectional approach and consecutive sampling, 112 subjects were divided into controlled (HbA1c < 7%) and uncontrolled (HbA1c ≥ 7%) groups. Data were collected from RSUP H. Adam Malik Medan through laboratory tests for whole blood, uric acid, and HbA1c levels. Pearson or Spearman correlation tests were used to assess relationships between variables with a significance level of p < 0.05. Significant demographic differences were found between groups, with higher uric acid and HbA1c levels in the uncontrolled DM group. Positive correlations were observed between uric acid and NLR, as well as uric acid and HbA1c, in both groups. Additionally, a strong positive association between HbA1c and NLR was found in both groups. Uric acid, NLR, and HbA1c are correlated in both controlled and uncontrolled type 2 diabetes mellitus.
Co-Authors Adisasmito, Wiku Bakti Bawono AIRLANGGA, EKA Ayodhia P. Pasaribu, Ayodhia P. Bernando, Andri Bugis M. Lubis, Bugis M. Dwi Anggraini Elsha, Elsha Sinulingga Elvira Fithria Aldy Ginting, Almaycano Hadi, Denny Harahap, Juliandi Hasan, Refli Hasibuan, Hasrul Herman Hariman Ichwan, M Inke Nadia Diniyanti Lubis, Inke Nadia Diniyanti M. Nafchi, Asgar Malisie, Ririe F. manihar Situmorang, manihar Merlin, Asri Muhammad Zarlis, Muhammad Novisari Soeroso, Noni Rahma, Hadiyatur Ratna Akbari Ganie, Ratna Akbari Rini Savitri Daulay, Rini Savitri Samodra, Yoseph Leonardo Santi Syafril, Santi Siallagan, Delpiana Sinaga, Bintang Yinke Magdalena Siregar, Ari Ramadhan Siregar, Dewi Indah Sari Situmorang, Immanuel Tako, Frida Welhelmina Taufik Sungkar, Taufik Wahyuni, Arlinda S. Yanni, Gema Nazri