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All Journal Open Access Indonesian Journal of Medical Reviews
Catherine
Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia
Health Professions Medicine & Pharmacology

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Mechanisms of Cellular Adaptation and Change: A Narrative Literature Review Rachmat Hidayat; Catherine
Open Access Indonesian Journal of Medical Reviews Vol. 3 No. 2 (2023): Open Access Indonesian Journal of Medical Reviews
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/oaijmr.v3i2.298

Abstract

Injury to cells and the surrounding environment, called the extracellular matrix, triggers injury to tissues and organs. Although a normal cell is limited by narrow boundaries of structure and function, it is capable of adapting to biological demands or stress to maintain a steady state called homeostasis. Adaptation is a reversible, structural, or functional response to normal or physiological conditions and adverse or pathological conditions. This review aimed to describe the mechanism of cellular adaptation in the human body. Cells adapt to the environment to escape and protect against injury. Adaptation of the cell, be it normal or injured, this condition lies somewhere between these two conditions. The most significant adaptive changes in cells include atrophy (decreased cell size), hypertrophy (increased cell size), hyperplasia (increased cell number), and metaplasia (reversible replacement of one mature cell for another less mature cell or change in phenotype). Dysplasia (a disorder of cellular growth) is not considered a true cellular adaptation but rather an atypical hyperplasia. In conclusion, cellular adaptation is a central and common part of many disease conditions.
Co-Authors RACHMAT HIDAYAT