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Zikrul Haikal
Fakultas Kedokteran, Universitas Mataram
Agriculture, Biological Sciences & Forestry Computer Science & IT Public Health

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Hubungan Perbedaan Beban Trauma Dengan Gambaran Histopatologi Edema Sel Otak Tikus Pasca Cedera Otak Traumatik: The Relationship between Trauma Load Differences and Histopathological Description of Rat Brain Cell Edema Post Traumatic Brain Injury Bayu Putra Wibowo; Rohadi Rohadi; Lale Maulin Prihatina; Zikrul Haikal
JURNAL SAINS TEKNOLOGI & LINGKUNGAN Vol. 9 No. 1 (2023): JURNAL SAINS TEKNOLOGI & LINGKUNGAN
Publisher : LPPM Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jstl.v9i1.428

Abstract

Traumatic brain injury is a condition of the head structure that is impacted or traumatized, causing disruption of brain function. This condition is one of the types of injuries that have the most severe effects on disability and death. Globally, 60 million people suffer from traumatic brain injury each year, with the most common complication being intracranial hemorrhage which increases the risk of death and disability. The incidence of traumatic brain injury is most common in the age group of children (0 - 4 years), adolescents and young adults (15-24 years) and the elderly (> 65 years). Where the most common causes are falls and vehicle accidents. This study aims to determine the histopathological description of edema in rat brain cells after traumatic brain injury and to analyze the relationship between differences in trauma burden and histopathological features of brain cell edema in rats after traumatic brain injury. This research is an experimental conducted by giving treatment to the object under study and then observing it. Sampling in this research will use purposive sampling. Where the researcher has determined the criteria of the sample to be used in the study so that it can represent the population. Based on the research conducted, it was found that there was a relationship between differences in trauma load and the percentage of brain cell edema in rats after experiencing traumatic brain injury. Where the greater the load given, the wider the surface of the brain that is experiencing edema. The results showed a significant edema appearance compared to the histopathological appearance of rat brain cells in normal samples. In addition, it was found that there was an increase in the percentage of areas with edema with a greater trauma load p=0.8156.
Hubungan Perbedaan Beban Trauma Dengan Gambaran Histopatologi Hematoma Otak Tikus Pasca Cedera Otak Traumatik: The Relationship between Trauma Load Differences and Histopathological Description of Rat Brain Hematoma Post Traumatic Brain Injury Gibran Ihza Sukma; Rohadi Rohadi; Lale Maulin Prihatina; Zikrul Haikal
JURNAL SAINS TEKNOLOGI & LINGKUNGAN Vol. 9 No. 1 (2023): JURNAL SAINS TEKNOLOGI & LINGKUNGAN
Publisher : LPPM Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jstl.v9i1.429

Abstract

Traumatic brain injury is defined as trauma to the head that can cause physical, intellectual, emotional, social or behavioral changes. Traumatic brain injury is one of the leading causes of morbidity and mortality worldwide. Brain injury Traumatic disorders are among the most common disorders in neurology. in the brain, it accounts for 2 to 15% of all head injuries. This study aims to determine the histopathological picture of brain hemorrhage in rats after experiencing traumatic brain injury and to analyze the relationship between differences in trauma load and the histopathological appearance of brain hemorrhage in rats after experiencing traumatic brain injury. This research is an experimental study conducted by giving treatment to the object under study and then observing it. Sampling in this research will use purposive sampling. Where the researcher has determined the criteria of the sample to be used in the study so that it can represent the population. : The results of this study there was no significant relationship between the percentage of the degree of brain hematoma in rats after experiencing traumatic brain injury. These results explain that bleeding in the brain usually progresses about 4-8 hours after brain injury occurs. In addition, the percentage of bleeding areas with trauma burden was p = 2.890.
Hubungan Antara Perbedaan Beban Trauma Dengan Gambaran Histopatologi Inflamasi Otak Tikus Pasca Mengalami Cedera Otak Traumatik: Relationship Between Differences In Trauma Load With Histopathological Description Of Rat Brain Inflammation Post Traumatic Brain Injury Muzakki Hasnan Ali; Rohadi Rohadi; Lale Maulin Prihatina; Zikrul Haikal
JURNAL SAINS TEKNOLOGI & LINGKUNGAN Vol. 9 No. 1 (2023): JURNAL SAINS TEKNOLOGI & LINGKUNGAN
Publisher : LPPM Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jstl.v9i1.430

Abstract

Brain injury is a damage to the brain, not congenital or degenerative, but caused by an attack or physical impact from the outside. Traumatic brain injury (TBI) is an injury that occurs when a force transmitted to the head or body causes neuropathological damage and dysfunction. TBI is one of the most common head injuries worldwide. This disorder affects 2% of the world's population each year and is the leading cause of death and serious disability in children and young adults. Getting hit or bumped into objects, motor vehicle crashes and falls, and intentional self-injury are the most common causes of TBI. This study aims to determine the histopathological description of brain inflammation in post-traumatic brain injury rats and analyze the relationship between differences in trauma burden and histopathological features of brain inflammation in post-traumatic brain injury rats. This research is an experimental study conducted by giving treatment to the object under study and then observing it. Sampling in this research will use purposive sampling. Where the researcher has determined the criteria of the sample to be used in the study so that it can represent the population. The results of this study indicate that there is a relationship between differences in trauma load and the percentage of rat brain inflammation after experiencing traumatic brain injury. The results of data analysis from this study for the Pearson test obtained a significance value of 0.00 so that there is a correlation between differences in trauma load and the percentage of brain cell inflammation in rats after experiencing traumatic brain injury. The Pearson correlation value of this data is 0.7621 which means a strong correlation. The results showed a significant inflammatory picture compared to the histopathological appearance of rat brain cells in normal samples.
Co-Authors Bayu Putra Wibowo Gibran Ihza Sukma Lale Maulin Prihatina Muzakki Hasnan Ali Rohadi