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All Journal Jurnal Farmasi Sains dan Komunitas BERDIKARI : Jurnal Inovasi dan Penerapan Ipteks
Nanik Marfu'ati
Universitas Muhammadiyah Semarang
Computer Science & IT Education Medicine & Pharmacology

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Pembuatan Simplisia dan Teknik Penyiapan Obat Tradisional Jahe Merah dan Daun Pepaya untuk Standardisasi Dosis Maya Dian Rakhmawatie; Nanik Marfu'ati
Berdikari: Jurnal Inovasi dan Penerapan Ipteks Vol 11, No 1 (2023): February
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/berdikari.v11i1.16717

Abstract

Many Family Welfare Empowerment Groups (PKK) developed a family medicinal plant garden (TOGA) whose results can be used for traditional medicine for residents in their area. Medicinal plants are usually prepared from the decoction of fresh ingredients obtained from the TOGA garden. Medicinal plant products must be used immediately to avoid the risk of spoilage, especially when the yield is abundant. One of the technologies to reduce the spoilage of medicinal plant products needs to be made in the form of Simplicia. The dry form of Simplicia can make it easier for the public to standardize the doses of medicinal plants and prepare standardized decoctions using the infusion and decoct methods. The service program aims to increase knowledge and skills in making Simplicia and preparation techniques for traditional red ginger and papaya leaf medicines according to standard dosages. The methods used in implementing the program were tutorials and practices. The results of the service program were as follows: 1) Knowledge of PKK partner women in the Sambiroto and Sendang Mulyo areas, Semarang, quantitatively increased significantly by 13.83% as shown by the results of the pre-test vs. post-test, 69.5 vs. 83.33, p-value 0.034; 2) Knowledge and technical skills for preparing traditional medicines using the infusion and decoct methods also increased significantly.
Secondary Metabolites Production of Bacillus spp. Isolated from Sea Cucumbers (Holothuria scabra) and their Activity against Mycobacterium smegmatis Maya Dian Rakhmawatie; Aida Zakiyatul Fikriyah; Ika Dyah Kurniati; Nanik Marfu'ati; Stalis Norma Ethica
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 20, No 2 (2023)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.004843

Abstract

New anti-tuberculosis agents are very important due to Multidrug-Resistant and Extensively Drug-Resistant Tuberculosis problems. Mycobacterium smegmatis can be used to replace Mycobacterium tuberculosis as bacteria test to increase the velocity of anti-tuberculosis screening. To answer the need for new drugs, exploration of secondary metabolites from Bacillus spp. can be conducted. Bacillus spp. are known to produce antimicrobials, including discovery of iturins, fengycins, and pumilacidins. This study explored the Bacillus spp. isolated from fermented intestines of Holothuria scabra. The production of Bacillus sp. Holothuria scabra Fermented Intestine (HSFI) secondary metabolites was done using culture media containing starch as a carbon source, as well as yeast and peptone as a nitrogen source. Production capacity of secondary metabolites of Bacillus sp. HSFI was calculated, to determine its potential as an antibacterial producer. Inhibition testing of secondary metabolites of Bacillus sp. HSFI against M. smegmatis was performed using the Kirby-Bauer disk diffusion method. Based on the results of the inhibition test, it was concluded that Bacillus sp. HSFI-9 has the greatest potential to inhibit the growth of M. smegmatis, with a moderate inhibition (7.67 mm). Production of secondary metabolites from Bacillus sp. HSFI-9 is exceptionally good with an extract production capacity of 24.6 mg/L.
Co-Authors Aida Zakiyatul Fikriyah Ika Dyah Kurniati Maya Dian Rakhmawatie Stalis Norma Ethica