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All Journal Jurnal Ilmiah Kesehatan Sandi Husada Jurnal Ilmiah Ilmu Kesehatan
Iwan Saka Nugraha
Institut Teknologi dan Kesehatan Bintang Persada
Religion Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Andrografolid : Potensi Sebagai Antiaterosklerosis Pada Sitokin Il-1β Putu Yudha Ugrasena; Iwan Saka Nugraha; Ni Wayan Rika Kumara Dewi
Jurnal Ilmiah Kesehatan Sandi Husada Vol 12 No 1 (2023): Jurnal Ilmiah Kesehatan Sandi Husada
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Akademi Keperawatan Sandi Karsa (Merger) Politeknik Sandi Karsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35816/jiskh.v12i1.991

Abstract

The focus is how the role of cytokines in atherosclerosis as a chronic inflammatory disease, as it is known that cytokines regulate complex inflammatory responses in atherosclerotic plaques, especially IL-1β. Sambiloto (Andrographis paniculata) is a plant with various pharmacological activities. Andrographolide (AND) is the main bioactive compound in the diterpene lactone group. This literature study aims to assess the potential of AND on the proinflammatory cytokine IL-1 β as an antiatherosclerosis. This type of research is a qualitative review of various studies using sambiloto plants or andrographolide compounds (AND). Search literature using the Google Scholar database. Keywords used "Andrographis paniculata, andrographolide, IL-1β, Atherosclerosis. The results showed that AND has effects as an anti-inflammatory, antiatherosclerosis as well as cardiovascular-related diseases. There are not many articles on the activity of AND in IL-1β against atherosclerosis, but AND can provide inhibitory activity of the cytokine IL-1β against inflammation. Not many researchers have discussed the pharmacological effects of AND as an antiatherosclerotic on IL-1β therapeutic targets, but from the results of the review AND has a strong potential in inhibiting IL-1 cytokine secretion β.
DETERMINAN PERILAKU TERHADAP PENGGUNAAN ANTIBIOTIK PADA BALITA DI WILAYAH KERJA PUSKESMAS KUBU II KARANGASEM Ida Ayu Nyoman Trijayanti Ida Ayu Nyoman Trijayanti; iwan saka nugraha; Putu Melista Putri Putu Melista Putri
PrimA: Jurnal Ilmiah Ilmu Kesehatan Vol. 11 No. 1 (2025): PrimA: Jurnal Ilmiah Ilmu Kesehatan
Publisher : LPPM STIKES Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47506/qte8sa96

Abstract

Introduction: Antibiotics are recognized as crucial therapeutic compounds in the prevention and management of infections, especially in the pediatric population. In Indonesia, infectious diseases persist as the leading contributors to both morbidity and mortality in children under five, triggering an urgent need for quick and efficient medical interventions. In clinical practice, antibiotics are often chosen as the primary response by parents and medical personnel due to their perceived instant effectiveness. However, the use of antibiotics without proper scientific and policy considerations have the capacity to induce enduring negative consequences, affecting not only individuals but also reverberating across global scale. Objective: This research’s objective is to elaborate the influence of occupation, knowledge, education level, gender, age, and perception on the behavior of Antibiotic use behavior in toddlers at Public Health Center whose working areas are in Kubu II. Method: This study used a cross-sectional quantitative study method. This study has a population of parents of toddlers aged 0 to 59 months in Tianyar Tengah Village whose working area is in Kubu II, totaling 186 participants. Results: This research reveals that some predictors such as occupation, educational attainment, knowledge, and perception play a crucial role in shaping antibiotic usage patterns among children under five. While gender and age did unsignificantly affected. The educational level emerges as the most significant predictor influencing antibiotic usage patterns in children under five. Conclusion: Education level was the most influential predictor of antibiotic use in under-fives.
Co-Authors Ida Ayu Nyoman Trijayanti Ida Ayu Nyoman Trijayanti Ni Wayan Rika Kumara Dewi Putu Melista Putri Putu Melista Putri Putu Yudha Ugrasena