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All Journal CAKRA KIMIA (Indonesian E-Journal of Applied Chemistry) Meditory : The Journal of Medical Laboratory JFM (Jurnal Farmasi Malahayati) JURNAL ILMIAH KESEHATAN SANDI HUSADA Medicra (Journal of Medical Laboratory Science/Technology) Jurnal Farmasi dan Sains Indonesia (JFSI) Muhammadiyah Medical Journal Jurnal Pengabdian kepada Masyarakat Wahana Usada JURNAL SKALA HUSADA: THE JOURNAL OF HEALTH Jurnal Yoga Dan Kesehatan Jurnal Ilmiah Kesehatan Sandi Husada Jurnal Pharmactive
Ni Wayan Rika Kumara Dewi
Institut Teknologi Dan Kesehatan Bintang Persada
Religion Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Electrical & Electronics Engineering Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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ISOLASI DAN IDENTIFIKASI SENYAWA AKTIF ANTIRADIKAL BEBAS DARI KULIT BATANG KEPUH (Sterculia foetida L.) Ni Wayan Rika Kumara Dewi; Made Dwike Swari Shanti
Jurnal Farmasi Malahayati Vol 5, No 1 (2022)
Publisher : Jurnal Farmasi Malahayati (JFM)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jfm.v5i1.6799

Abstract

Penelitian ini bertujuan untuk menentukan senyawa aktif antiradikal bebas dari kulit batang kepuh (Sterculia foetida L.). Uji aktivitas dilakukan secara invitro dengan metode DPPH (1,1-diphenyl-2-pycrylhidrazyl). Teknik pemisahan dilakukan dengan kromatografi kolom dan diidentifikasi dengan spektrofotometer FTIR dan UV-Vis.Hasil maserasi yang memiliki aktivitas adalah ekstrak etanol. Selanjutnya dipartisi dengan etil asetat dan kloroform, diperoleh ekstrak kloroform yang menunjukkan hasil uji aktivitas antiradikal bebas yang paling tinggi dan dilanjutkan teknik pemisahan. Ekstrak dipisahkan dengan kromatografi kolom dengan fase diam silika gel. Pemisahan dan pemurnian menghasilkan 9 fraksi gabungan (A, B, C, D, E, F, G, H, I). Berdasarkan uji antiradikal bebas, semua fraksi menunjukkan hasil positif antiradikal bebas, yang relatif murni secara KLT adalah fraksi B yang berbentuk serbuk berwarna kuning muda seberat 0,0325 gram. Identifikasi dengan pereaksi Leibermann Burchard menunjukkan isolat FB adalah golongan senyawa triterpenoid. Spektrum UV-Vis dari isolat FB dengan dua puncak utama yang muncul pada panjang gelombang 212 nm sebagai λ maks diduga jenis transisi yang terjadi pada panjang gelombang 212 nm kemungkinan diakibatkan oleh terjadinya transisi elektronik dari n-σ* dari kromofor C=O dan puncak yang lain berupa bahu pada panjang gelombang 284 nm diakibatkan oleh terjadinya transisi elektronik n-π* dari ikatan rangkap C=O. Dugaan ini diperkuat oleh data dari spektrum inframerah yang menunjukkan adanya gugus fungsi –OH, CH alifatik, C=O, C=C alifatik, dan C-O.
Gambaran Kadar Hemoglobin Dan Protein Urin Pada Ibu Hamil Luh Putu Rinawati; Ni Putu Ditya Prabandari Dewi; Ni Putu Yulia Rahma Dewi; Ni Komang Omik Trianita Udiana; Ni Wayan Rika Kumara Dewi; Heri Setiyo Bekti
Meditory : The Journal of Medical Laboratory Vol 10, No 2 (2022): Meditory, Volume 10 No. 2 Tahun 2022
Publisher : Jurusan Teknologi Laboratorium Medis, Poltekkes Kemenkes Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33992/meditory.v10i2.2279

Abstract

Backgrounds of hemoglobin is a metalloprotein in red blood cells that functions as an oxygen booster from the lungs to the rest of the body. To maintain hemoglobin levels in the body, especially in pregnant women, it is necessary to have adequate intake of nutrients, namely iron. If the intake of iron in pregnant women is less, it will increase the risk of anemia. Anemia is a condition or condition that causes low levels of hemoglobin (Hb). Albuminuria or proteinuria is a condition in which urine or urine contains an abnormal amount of albumin. Throughout pregnancy, pregnant women are usually advised to take a urine test. One of the focuses of the urine test is to determine urine protein levels in pregnant women. In pregnant women, there is a phase where urine protein levels increase, namely, lack of fluids, exposure to cold and extreme weather, new strenuous activities, and emotional stress also often causes urine protein levels in pregnant women to increase, and impaired kidney function. or urinary tract infection. The method we used in this research is descriptive research method to describe the levels of hemoglobin (Hb) and urine protein in pregnant women at the Ubud 1 Public Health Center, Gianyar-Bali. With the sampling technique using the probability sampling method, with a simple random sampling technique. The results of 41 respondents, that pregnant women who have normal Hb levels (≥ 11 g/dL) at Puskesmas Ubud 1 were found to be more than pregnant women who have low Hb levels ( 11 g/dL). And from the total sample, as well as 2 pregnant women from the urine protein level examination data were positive. The conclusion after averaging the Hb and urine protein levels of pregnant women at the ubud 1 health center that it can be said that the health condition of pregnant women is quite good, but there are still some respondents who show results that are not in accordance with normal limits, therefore it is important to maintain health and pattern healthy living.Keywords: hemoglobin, urine protein, pregnant women
Peningkatan Pemahaman Siswa Farmasi tentang Peran Farmakoekonomi dalam Pelayanan Kesehatan di SMK Bintang Persada Denpasar Made Dwike Swari Santi; Ni Wayan Rika Kumara Dewi; Gede Terima Yasa
Jurnal Pengabdian kepada Masyarakat Wahana Usada Vol. 4 No. 2 (2022): Desember : Jurnal Pengabdian kepada Masyarakat Wahana Usada
Publisher : Sekolah Tinggi Ilmu Kesehatan KESDAM IX/Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47859/wuj.v4i2.284

Abstract

Background: Pharmacoecomics has been defined as the description and analysis of the costs of drug therapy to health care systems and society. Pharmacoeconomics research identifies, measure, and compares the costs and consequences of pharmaceutical product and service. Within this framework, research and methods related to cost-minimization, cost-effectiveness, quality-of-life and other humanistic assessments are include. In-essence, pharmacoeconomics analysis uses tools for examining the impact of alternative drug therapies and other medical interventions Based on this background, the author is interested to explain about the role of Pharmacoecomics on health service in pharmacist students at Bintang Persada School, Denpasar. Purpose: The purpose of this activity is as a form of implementation of Tri Dharma Stikes Bali Wisnu Dharma Denpasar. Methods: Participants who took part in this activity were 83 students using the pretest and posttest methods. Results: The results obtained were an increase in the pretest score (before being given education) which was 62.11% to 83.22% in the posttest result (after being given education). Conclusion: There is a significant relationship between posttest scores, which increases after education is held, so pharmacoeconomics education needs to be given and pharmaceutical products utilization in health service followed by cost utillity evaluation and cost effectiveness as well as impact evaluation of quality adjusted life years of patients.
The Kajian Manfaat Tumbuhan Kepuh (Sterculia Foetida L.) Dan Terapi Yoga Sebagai Pengobatan Tradisional Ni Wayan Rika Kumara Dewi; Iwan Saka Nugraha; Made Prita Artika
Jurnal Yoga dan Kesehatan Vol 6 No 1 (2023): Volume 6 Nomor 1 Maret 2023
Publisher : UHN IGB Sugriwa Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25078/jyk.v6i1.2007

Abstract

Kepuh plant (Sterculia foetida L.) is one of the plants that have the potential as a source of new medicines which are rich in compounds used as modern medicines, pharmaceutical intermediates, and main compounds in natural medicinal ingredients. Traditional medicine in Bali is often called Usada which contains the science of diagnosing diseases, medicinal ingredients, and prayers. The community is also familiar with Ayurveda, namely the use of herbal medicines and yoga therapy. The development of traditional medicine into herbal medicine requires an analysis of the activity of primary metabolites present in the Kepuh plant (Sterculia foetida L.). In addition, it is also necessary to know the effect of yoga therapy on traditional medicine. This study uses a descriptive method using a structured article review method. Based on secondary data obtained from several scientific journals, it is known that the biological activities of secondary metabolites in the Kepuh plant (Sterculia foetida L.) are antibacterial, antioxidant, antifungal, antiprotozoal, cytotoxic, thrombolytic, anti-rheumatic, analgesic, antipyretic, antidiabetic, insecticidal, antifeedant, and microbicidal effects. So scientifically the Kepuh plant (Sterculia foetida L.) can be used as a source of new drugs which are rich in compounds used as modern medicines, pharmaceutical intermediates, and main compounds in natural medicinal ingredients. Likewise, the effect of giving yoga therapy to traditional medicine which is a non-pharmacological treatment can help the healing process in patients with certain diseases. However, it is necessary to carry out further research on the use of the Kepuh plant as a herbal medicine in combination with yoga therapy.
Andrografolid : Potensi Sebagai Antiaterosklerosis Pada Sitokin Il-1β Putu Yudha Ugrasena; Iwan Saka Nugraha; Ni Wayan Rika Kumara Dewi
Jurnal Ilmiah Kesehatan Sandi Husada Vol 12 No 1 (2023): Jurnal Ilmiah Kesehatan Sandi Husada
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Akademi Keperawatan Sandi Karsa (Merger) Politeknik Sandi Karsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35816/jiskh.v12i1.991

Abstract

The focus is how the role of cytokines in atherosclerosis as a chronic inflammatory disease, as it is known that cytokines regulate complex inflammatory responses in atherosclerotic plaques, especially IL-1β. Sambiloto (Andrographis paniculata) is a plant with various pharmacological activities. Andrographolide (AND) is the main bioactive compound in the diterpene lactone group. This literature study aims to assess the potential of AND on the proinflammatory cytokine IL-1 β as an antiatherosclerosis. This type of research is a qualitative review of various studies using sambiloto plants or andrographolide compounds (AND). Search literature using the Google Scholar database. Keywords used "Andrographis paniculata, andrographolide, IL-1β, Atherosclerosis. The results showed that AND has effects as an anti-inflammatory, antiatherosclerosis as well as cardiovascular-related diseases. There are not many articles on the activity of AND in IL-1β against atherosclerosis, but AND can provide inhibitory activity of the cytokine IL-1β against inflammation. Not many researchers have discussed the pharmacological effects of AND as an antiatherosclerotic on IL-1β therapeutic targets, but from the results of the review AND has a strong potential in inhibiting IL-1 cytokine secretion β.
PENGARUH EKSTRAK DAUN KELOR TERHADAP STATUS GIZI BALITA DI DESA TEJAKULA Nugraha, Iwan Saka; Dewi, Ni Wayan Rika Kumara; Darmayanti, Putu Ayu Ratna
JFM (Jurnal Farmasi Malahayati) Vol 7, No 2 (2024)
Publisher : Jurnal Farmasi Malahayati (JFM)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jfm.v7i2.15735

Abstract

Latar Belakang: Stunting (tinggi/panjang berdasarkan usia dengan z-score kurang dari -2 SD) dan defisiensi mikronutrien adalah dua contoh masalah gizi. Hal tersebut menjadikan status gizi balita sebagai indikator kesehatan yang penting karena balita merupakan kelompok yang rentan terhadap masalah gizi. Daun kelor mengandung arginin dan histidin, yang sangat penting bagi anak-anak yang tidak dapat menghasilkan cukup protein untuk pertumbuhan mereka. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak daun kelor terhadap peningkatan status gizi balita. Metode: Jenis desain penelitian ini menggunakan metode penelitian eksperimental, analitis dengan desain kuasi-eksperimental. Desain yang digunakan adalah desain one-group pre-test dan post-test. Populasi dalam penelitian ini adalah semua anak usia 1 sampai 5 tahun yang mengalami kekurangan gizi berjumlah sepuluh anak dengan total sampling. Hasil: penelitian menunjukkan bahwa semua balita mengalami peningkatan berat dan tinggi badan setelah diberi 10 gram ekstrak daun kelor selama 14 hari. Hasil uji statistik Wilcoxon Signed Ranks Test, diperoleh nilai sig. = 0,002, yang berarti lebih kecil dari α 0,005, yang berarti pemberian ekstrak daun kelor berpengaruh signifikan terhadap status gizi balita.
The Effect of Green Grape Extract on Serum Triglyceride Levels in Rats: Pengaruh Pemberian Ekstrak Anggur Hijau terhadap Kadar Triglierida Serum pada Tikus Bekti, Heri Setiyo; Dewi, Ni Nyoman Astika; Rinawati, Luh Putu; Dewi, Ni Wayan Rika Kumara; Hadi, Mochammad Choirul
Medicra (Journal of Medical Laboratory Science/Technology) Vol. 7 No. 1 (2024): July
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/medicra.v7i1.1721

Abstract

Cardiovascular disease, one of which is coronary heart disease (CHD) is the main cause of death and morbidity caused by blockages in the coronary arteries (atherosclerosis). Elevated serum triglyceride levels can encourage the formation of atherosclerosis. Statins are the drugs most commonly used to lower triglyceride levels but have side effects, so new treatment are needed. Grapes are fruits that has many bioactive compounds such as proanthocyanidins and resveratrol which are believed to reduce triglyceride levels in serum. The purpose of this study was to determine the effect of green grape extract (Vitis vinifera) on triglyceride levels in male Wistar rats which were divided into 5 groups, namely P0 (fed with standard feed), P1 (fed with high cholesterol and then standard feed), P2 (fed with high cholesterol and simvastatin 0.2mg/200mgBW/day), P3 (fed with high cholesterol and grape extract at a dose of 500mg/200mgBW/day), and P4 (fed with high cholesterol and 250mg/200mgBW/day grape extract). Examination of triglyceride levels was carried out using the GPO-PAP method. Data analysis was performed with Annova test followed by Bonferroni test. The statistical test results showed that there were significant differences between each treatment group. The P3 group showed a lower average triglyceride level than P4 although it was still higher than P2. This showed that administration of green grape extract has an effect on decreasing serum triglyceride levels in all.
ISOLASI DAN IDENTIFIKASI SENYAWA ANTIOKSIDAN GOLONGAN FLAVONOID DARI EKSTRAK ETIL ASETAT DAUN PRANAJIWA (Euchresta horsfieldii Lesch Benn.) Dewi, Ni Wayan Rika Kumara; Gunawan, I Wayan; Puspawati, Ni Made
CAKRA KIMIA (Indonesian E-Journal of Applied Chemistry) Vol 5 No 1 (2017)
Publisher : Graduate Program of Applied Chemistry, Udayana University, Bali-INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (165.127 KB) | DOI: 10.24843/CK.2017.v05.i01.p04

Abstract

ABSTRAK: Penelitian ini bertujuan untuk menentukan aktivitas antioksidan dan mengidentifikasi senyawa golongan flavonoid yang terkandung dalam ekstrak etil asetat daun pranajiwa (Euchresta horsfieldii Lesch Benn.). Uji aktivitas antioksidan dilakukan secara invitro dengan metode DPPH (1,1-diphenyl-2-pycrylhidrazyl). Teknik pemisahan dilakukan dengan kromatografi kolom dan diidentifikasi dengan spektrofotometer FTIR dan UV-Vis. Hasil penelitian menunjukkan bahwa ekstrak etil asetat memiliki aktivitas antioksidan dengan nilai IC50 sebesar 393,95 µg/mL dan kadar total flavonoid sebesar 6619,72 mg QE/100g atau 6,62 % QE. Pemisahan dan pemurnian ekstrak etil asetat menggunakan fase diam silika gel 60 dan fase gerak n-heksana:kloroform: etanol (20:1:1) yang menghasilkan isolat aktif yang positif flavonoid (isolat FE) yang diduga merupakan senyawa flavonoid golongan flavonol yaitu 3,5,7,3’,4’-pentahidroksi flavonol. ABSTRACT: The present study was conducted to determine antioxidant activity and to identify the flavonoid active compounds from ethyl acetate extracts of Pranajiwa leaves. In vitro antioxidant activity was carried out using DPPH (1,1-diphenyl-2-pycrylhidrazyl) method. The separation of the ethyl acetate extracts was conducted by column chromatography and the identification by using FTIR and UV-Vis spectrophotometer. The results showed that ethyl acetate extract has antioxidant activity with IC50 value of 393,95 µg/mL and the total flavonoid of 6619,72 mg QE /100g or 6,62% QE. The separation and purification of ethyl acetate extract was chromatography column on silica gel 60 and the solvent n-hexane:chloroform:ethanol (20:1:1) based on UV-Vis and Infrared spectra positive flavonoid isolate (isolates FE) was tentaviely identified as 3,5,7,3',4'-pentadihydroxy flavonols.
The Effectiveness of Green Grape Extract (Vitis vinifera) on Decreasing White Rat (Rattus novergicus) Triglycerides Levels Arwati, Ketut Lilik; Dewi, Ni Nyoman Astika; Bekti, Heri Setiyo; Dewi, Ni Wayan Rika Kumara; Saransi, Andi Udin
Muhammadiyah Medical Journal Vol 3, No 1 (2022): Muhammadiyah Medical Journal (MMJ)
Publisher : Faculty of Medicine and Health Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24853/mmj.3.1.1-9

Abstract

Background: Grapes (Vitis vinifera) are a source of antioxidants with high content of polyphenols and anthocyanins. Grape skin is rich in flavonoids. Anthocyanins and flavonoids have the effect of lowering blood triglyceride levels. Purposes: This study aimed to determine the effect of using green grape extract (GGE) in lowering triglyceride levels in the blood. Methods: Five groups of white male rats (Rattus novergicus) were divided into a negative control group (KN), positive control (KP), rats with a GGE dose of 100 mg/200g BW as P1, rats with a GGE dose of 250mg/200g BW as P2, and rats with GGE dose of 500 mg/200g BW as P3. Each group was given a hypercholesterolemic diet for five weeks. Groups P1, P2, and P3 were given GGE according to their respective doses for 14 days, then measured triglyceride levels in the blood. Results: The results showed that GGE 500mg/200g BW significantly reduced triglyceride levels in all treated mice. Conclusion: These results indicate that GGE has a great potential to treat dyslipidemia by lowering triglyceride levels in the blood.
Primers application with the Tso31 gene target in the molecular identification of Taenia solium Habibah, Nur; Bekti, Heri Setiyo; Kumara Dewi, Ni Wayan Rika; Rinawati, Luh Putu; Burhannuddin, Burhannuddin; Rakhmawati, Aprilia
Muhammadiyah Medical Journal Vol 2, No 1 (2021): Muhammadiyah Medical Journal (MMJ)
Publisher : Faculty of Medicine and Health Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (271.651 KB) | DOI: 10.24853/mmj.2.1.35-40

Abstract

Background: taeniasis is a zoonotic disease caused by Taenia spp. Human taeniasis caused by Taenia solium can be acquired after consumption of raw insufficiently cooked infected pork meat. Pigs are intermediate host for T.solium. Pigs acquired this infection by eating human feces that contained T.solium eggs. Pigs infected with T.solium can be transmitted to humans. Purposes: identification of T.solium in pig is important because it is indicator of T.solium transmission. Microscopic examination of T.solium eggs is considered less effective and efficient so that many other methods are developed for T.solium detection such as molecular and immunology. Method: This method used specific primer which can detect the Tso31 gene in T.solium. Tso31 gene is one of the most promising antigens to differentiate T.solium from T.saginata. Pig feces samples were taken by random sampling technique from 7 pig farms in Denpasar. Result: from the 30 samples, we found one sample that which gave a single amplification product of 234 bp. This indicates that the pig farms in Denpasar have been infected with T.solium. Conclusion: it is necessary to do meat inspection properly in the market as well as health education about the dangers and impacts of T.solium infection in the community.
Co-Authors ANDI UDIN SARANSI Artika, Made Prita Arwati, Ketut Lilik Burhannuddin Dewi, Ni Nyoman Astika Dyah Ratna Ayu Puspita Sari Gede Terima Yasa Heri Setiyo Bekti I Wayan Gunawan, I Wayan Iwan Saka Nugraha Iwan Saka Nugraha Kusdiharti, Meutia Sri Made Dwike Swari Santi Made Prita Artika Mochamad Choirul Hadi Ni Komang Omik Trianita Udiana Ni Luh Gde Mona Monika Ni Luh Gde Mona Monika Ni Made Puspawati Ni Made Suastini, Ni Made Ni Putu Ditya Prabandari Dewi Ni Putu Gita Puspita Sari Ni Putu Gita Puspita Sari Ni Putu Yulia Rahma Dewi Nur Habibah Prita Artika, Made Putri, Pande Putu Cintya Wiarni Putu Ayu Ratna Darmayanti Putu Yudha Ugrasena Rakhmawati, Aprilia Rinawati, Luh Putu Sukma Dinda, Ni Made Ayu suryantara, a.a bagus Yasa, Gede Trima