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All Journal JURNAL ILMIAH SIMANTEK Majalah Ilmiah METHODA Jurnal Kedokteran Methodist
Salomo Garda Utama Simanjuntak
Universitas Methodist Indonesia
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PATOFISIOLOGI GASTROPATI NSAID Salomo Garda Utama Simanjuntak; Jekson Martiar Siahaan
Majalah Ilmiah METHODA Vol. 8 No. 2 (2018): Majalah Ilmiah METHODA
Publisher : Universitas Methodist Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46880/methoda.Vol8No2.pp73-82

Abstract

NSAIDs are first line therapy for arthritis and widely used in cases of trauma, postoperative pain and other aches. But in the use of NSAID drugs whether it is needed as an analgesic or as an anti-inflammatory all have more or less side effects on the gastrointestinal. The occurrence of side effects of NSAIDs on the gastrointestinal tract can be caused by the direct toxic effects of NSAIDs on the gastric mucosa so the mucosa becomes damaged. While the systemic effect is due to the ability of NSAIDs to inhibit the work of COX-1 which catalyzes the formation of prostaglandins. Prostaglandins in the gastrointestinal mucosa function to maintain mucosal integrity, regulate blood flow, mucous secretion, bicarbonate, epithelial proliferation, and mucosal resistance to damage. The clinical spectrum of NSAID gastropathy includes a wide range of clinical conditions, ranging from the mildest form of gastrointestinal discontrol. Endoscopically mucous congestion will occur, small erosions sometimes accompanied by bleeding
PREVALENSI DAN FAKTOR RISIKO KANKER PARU-PARU DI KOTA MEDAN: STUDI KASUS KONTROL SALOMO GARDA UTAMA SIMANJUNTAK
JURNAL ILMIAH SIMANTEK Vol 6 No 4 (2022): JURNAL ILMIAH SIMANTEK
Publisher : LP2MTBM MAKARIOZ

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Abstract

The cause of the incident in Medana City is the low socialization about preventing cancer from an early age, as well as the lack of public awareness in Medan City in conducting examinations or controls on this cancer. The purpose of this study is to investigate and analyze the relationship of risk factors, in terms of age, sex, smoking habits and self-control to clinics and hospitals on the incidence of lung cancer that has infected and made the atmosphere uncomfortable in the community. This study used descriptive analytical method. The population of this study amounted to 2430 people who tested lung cancer in several sub-districts, where the samples taken amounted to 66 lung cancer patients in all hospitals in Medan City. The results of the study concluded that from several risk factors that exist and are susceptible to lung cancer, namely people in the Medan Kota District area who have smoking habits and people who lack control over the body and also disease, especially the lungs, so that lung cancer is not detected comprehensively. People who are vulnerable to the risk of lung cancer are people in Medan Kota District who are in the age range of 40-49 years and work as entrepreneurs.
Antihyperglycemic Effect of Polyherbal Tea From Moringa oleifera, Cymbopogon citratus, and Stevia rebaudiana Leaves in Alloxan and HFD-Induced Mice (Mus musculus) Barukh Saro Talenta Zebua; Jekson Martiar Siahaan; Alex M. T. LumbanRaja; Suryati Sinurat; Salomo Garda Utama Simanjuntak
Jurnal Kedokteran Methodist Vol. 17 No. 2 (2024): Jurnal Kedokteran Methodist
Publisher : Universitas Methodist Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46880/jkm.v17i2.5375

Abstract

Diabetes Mellitus (DM) is a disease with metabolic disorders characterized by chronichyperglycemia and disorders of carbohydrate, fat, and protein metabolism due to insulinsecretion disorders. In general, DM patients require pharmacotherapy such as injectedinsulin or oral antidiabetic drugs. Pharmacological treatment is relatively expensive andneeds to consider its efficacy and safety. Therefore, this study explores natural sources suchas medicinal plants. The aim of this study was to determine the antihyperglycemic effect of acombination of boiled moringa leaves, lemongrass leaves and stevia leaves on mice (Musmusculus) induced by alloxan. In this study, 25 mice were divided into 5 groups. The micewill undergo adaptation for 7 days and then given HFD for 30 days. After 30 days, the micewill be given alloxan 170 mg/kgBW for 3 days to induce DM. After DM was successfullyinduced in mice, polyherbal tea combination of moringa leaves, lemongrass leaves and stevialeaves was made and given, then continued with evaluation blood glucose, blood glucosepercentage, body weight, body weight percentage, index lee and liver organ index. The groupgiven herbal tea combination of moringa leaves (Moringa oleifera), lemongrass leaves(Cymbopogon citratus) and stevia leaves (Stevia rebaudiana) with a concentration of 3.6mg/mL showed a better decrease in KGD and %KGD compared to other treatment groups.The decrease in BB, %BB and lee index was better in the group given a combination ofMoringa leaves (Moringa oleifera), Lemongrass leaves (Cymbopogon citratus) and Stevialeaves (Stevia rebaudiana) with a concentration of 7.2 mg/mL. The decrease in the liverorgan index was also better seen in the group given a combination of Moringa leaves(Moringa oleifera), Lemongrass leaves (Cymbopogon citratus) and Stevia leaves (Steviarebaudiana) with a concentration of 7.2 mg/mL. The group given herbal tea combination ofMoringa leaves (Moringa oleifera), Lemongrass leaves (Cymbopogon citratus) and Stevialeaves (Stevia rebaudiana) with a concentration of 3.6 mg/mL reduced BG and BGpercentage, while the group given herbal tea combination of Moringa leaves (Moringaoleifera), Lemongrass leaves (Cymbopogon citratus) and Stevia leaves (Stevia rebaudiana)with a concentration of 7.2 mg/mL reduced BW, BW percentage, Lee index, and hait organindex.
Co-Authors Alex M. T. LumbanRaja Barukh Saro Talenta Zebua Siahaan, Jekson Martiar Suryati Sinurat