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All Journal Pharmacology and Clinical Pharmacy Research Jurnal Abdi Insani
Lanny Indah Permatasari, Lanny Indah
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Agriculture, Biological Sciences & Forestry Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology

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Pharmacokinetic Changes and Dosage Adjustment of Digoxin in Elderly Patients with Atrial Fibrillation: A Narrative Review Alfaqeeh, Mohammed; Permatasari, Lanny I.; Khairinisa, Miski A.; Rusdiana, Taofik
Pharmacology and Clinical Pharmacy Research Vol 8, No 2 (2023)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v8i2.48284

Abstract

Digoxin is a cardiac glycoside medication commonly used to control rapid heart rates in Atrial Fibrillation (AF). However, digoxin has a narrow therapeutic range and can be associated with adverse effects, including increased mortality risk, especially in the elderly. Pharmacokinetic changes occur with aging, affecting the way drugs are absorbed, distributed, metabolized, and eliminated from the body. Thus, this narrative review aimed to assess the optimization of digoxin dosing in elderly patients with AF while considering pharmacokinetic changes due to aging. We performed a comprehensive computerized search of relevant English articles and a manual examination of reference lists from primary sources formed the basis of this scoping review. This involved an extensive computerized search of relevant articles in English and a manual search of the reference lists of original articles. The review highlighted the need to carefully monitor digoxin levels in elderly patients due to changes in body composition, protein binding, hepatic clearance, renal excretion, and other factors affecting drug metabolism. Furthermore, we summarized guidelines and recommendations for optimizing digoxin dosing in elderly patients with AF. By shedding light on the intricacies of optimizing digoxin dosing in the elderly with atrial AF and emphasizing the significance of accounting for age-related pharmacokinetic changes, this review offers valuable insights for healthcare practitioners and researchers in the field. Addressing these aspects is crucial to enhancing therapeutic outcomes and minimizing potential risks associated with digoxin therapy in this vulnerable patient population
EVALUASI PENGETAHUAN FAKTOR RESIKO DIABETES DAN DAMPAKNYA TERHADAP KADAR GULA DARAH SEWAKTU PADA MASYARAKAT KEMBANGAN UTARA, JAKARTA BARAT Nadiya Nurul Afifah; Reinaldo Pradana; Melisa Resmiati; Lanny Indah Permatasari
Jurnal Abdi Insani Vol 11 No 3 (2024): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v11i3.1917

Abstract

Diabetes Mellitus (DM) is a chronic, non-communicable metabolic disease with increasing prevalence and morbidity rates. There has been a 2% increase in DM prevalence among the population aged 15 years and older, with the highest prevalence found in DKI Jakarta (2.3%). Patients' understanding or knowledge of DM and its risk factors is closely related to the incidence of type II DM. The influence of education on public knowledge and the incidence of type II DM has also been widely demonstrated. This study was conducted to map the profile of Random Blood Glucose (RBG) levels and the knowledge of the residents of Kelurahan Kembangan Utara, West Jakarta, regarding the risk factors for type II DM and preventive measures. Methods: Community education was carried out through a mini-seminar on type II DM risk factors and prevention, followed by a questionnaire to assess knowledge, RBG testing, and consultation on the interpretation of the results, as well as the distribution of educational pamphlets as visual aids. Results and Conclusion: Respondents' knowledge about good nutrition as a preventive measure for type II DM was found to be lacking. However, their knowledge of type II DM risk factors and RBG levels was considered fairly good (75 and 112 mg/dL). The study also showed no significant differences in RBG levels among respondents with questionnaire scores of 60, 80, and 100 (p≥0.05), although the median RBG level in the 60-score group was the highest. Clinically, this could be interpreted to suggest that respondents with the lowest scores had the highest RBG levels.
Co-Authors Alfaqeeh, Mohammed Khairinisa, Miski A. Melisa Resmiati Nadiya Nurul Afifah Reinaldo Pradana Taofik Rusdiana