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Sriwidodo ., Sriwidodo
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Medicine & Pharmacology

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Potensi Liposom Sebagai Nanocarrier Antituberkulosis Pada Sediaan Inhalasi Parameswari, Natashya; ., Sriwidodo
Jurnal Farmasi Udayana Vol. 12, No. 2, tahun 2023
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2023.v12.i02.p08

Abstract

Tuberculosis (TB) is a respiratory tract infection that remains a global health problem to this day. There were more than 10, 6 million TB cases with approximately 1,5 million deaths in 2021. The oral therapy regimen consisting of isoniazid (INH), ethambutol (EMB), pyrazinamide (PZA) dan rifampicin (RIF), despite having a successful treatment rate up to 95% still faces limitation contributing to low treatment compliance and the development of drug-resistance Mtb strains. Strategy to overcome these limitations is to deliver drugs by inhalation as aerosols to the lung, the primary site of Mtb infection. Liposome-based nanocarriers have been proven effective in improving drug bioavailability and reducing toxicity. Therefore, this article review aims to explore the potential nanocarriers in pulmonary drug delivery systems
Co-Authors Parameswari, Natashya