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All Journal Jurnal Farmasi Udayana Indonesian Journal of Pharmaceutical Science and Technology JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Parameswari, Natashya
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Chemistry Computer Science & IT Education Health Professions Medicine & Pharmacology Other

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Potensi Liposom Sebagai Nanocarrier Antituberkulosis Pada Sediaan Inhalasi Parameswari, Natashya; ., Sriwidodo
Jurnal Farmasi Udayana Vol. 12, No. 2, tahun 2023
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2023.v12.i02.p08

Abstract

Tuberculosis (TB) is a respiratory tract infection that remains a global health problem to this day. There were more than 10, 6 million TB cases with approximately 1,5 million deaths in 2021. The oral therapy regimen consisting of isoniazid (INH), ethambutol (EMB), pyrazinamide (PZA) dan rifampicin (RIF), despite having a successful treatment rate up to 95% still faces limitation contributing to low treatment compliance and the development of drug-resistance Mtb strains. Strategy to overcome these limitations is to deliver drugs by inhalation as aerosols to the lung, the primary site of Mtb infection. Liposome-based nanocarriers have been proven effective in improving drug bioavailability and reducing toxicity. Therefore, this article review aims to explore the potential nanocarriers in pulmonary drug delivery systems
Studi In Silico Potensi Antidiabetes Senyawa pada Black Garlic sebagai Inhibitor Enzim DPP-4 Sudirman, Virgiana Keisha Rajabi Johni; Priana, Diva Dhaifina Mazaya; Puspitasari, Citra Dewi; Hutapea, Ezra Calista; Muntashir, Ilham Mohammad; Pribadi, Alya Puteri Agustina; Parameswari, Natashya; Aulifa, Diah Lia
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 2 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i2.47506

Abstract

Diabetes mellitus merupakan penyakit kronis yang berkaitan dengan gangguan metabolisme glukosa darah. Black Garlic memiliki potensi sebagai antidiabetes karena mengandung berbagai senyawa yang dapat mengontrol kadar gula darah seperti asam fenolik, senyawa flavonoid dan S-allyl-L-cysteine (SAC). DPP-4 merupakan enzim yang berperan penting sebagai target terapeutik dari gliptin dalam pengobatan diabetes mellitus mellitus tipe II. Penelitian ini dilakukan dengan tujuan membuktikan potensi senyawa pada Black Garlic sebagai inhibitor enzim DPP-4 secara in silico melalui metode penambatan molekuler. Berdasarkan hasil penelitian, SAC memiliki nilai energi ikatan sebesar -5,36 kkal/mol dan nilai konstanta inhibisi sebesar 118,08 μM. Hal ini menunjukkan bahwa ikatan antara senyawa SAC dengan enzim DPP-4 bersifat stabil dan terbukti berpotensi sebagai inhibitor enzim DPP-4 dibandingkan keempat senyawa uji lainnya. Namun, senyawa SAC tidak lebih baik dari ligan alaminya karena memiliki nilai energi ikatan dan konstanta inhibisi yang lebih kecil. Oleh karena itu dapat disimpulkan bahwa senyawa SAC pada Black Garlic tidak lebih efektif dibandingkan dengan ligan alaminya yaitu Vildagliptin tetapi tetap dapat berpotensi sebagai inhibitor enzim DPP-4.
In Silico Evaluation: Bioactive Compounds in Soursop Plant (Annona muricata L.) as Caspase-3 Inhibitor for Prostate Cancer Aristokrat, Aria; Widati Aqila Rumawan, Maritsa; Amalia Hanifa, Zahra; Luthfiyah Rahmani, Syifa; Hanifah; Parameswari, Natashya; Puteri Agustina Pribadi, Alya; Lia Aulifa, Diah
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 11 No. 1 (2024): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v11i12024.1-11

Abstract

Background: Prostate cancer has become one of the leading causes of death in men. Cancer patients often seek alternative treatments apart from chemotherapy, radiation therapy, and surgery. The use of medicinal plants in both preventive and curative actions in healthcare has been widely recognized. One of the plants known to have anticancer activity is the soursop leaf (Annona muricata L.). Objective: This study was conducted to explore the potential of active compounds contained in A. muricata as drug candidates for the inhibition of caspase-3 in silico. Methods: The research began with the prediction of Lipinski's Rule of Five and ADMET properties for the compounds found in A. muricata. The prediction process was followed by pharmacophore modelling and molecular docking simulations on caspase-3 (PDB: 1NME) as the target protein and 2-hydroxy-5-(2-mercapto-ethylsulfamoyl)-benzoic acid as the natural ligand using AutoDockTools 1.5.6. Results: Based on the molecular docking results, 22 test ligands were able to form bonds with the caspase-3 enzyme. The two best interactions were observed with the test ligands, Isolaureline and S-norcorydine, with binding energy values of -6.20 kcal /mol and -6.12 kcal /mol and inhibition constant values of 28.65 µM and 32.53 µM. In terms of receptor-target interactions, these two compounds also exhibited hydrogen bonding and van der Waals interactions similar to the natural ligand. Conclusion: The best bioactive compounds in A. muricata (Isolaureline and S-norcorydine) were predicted to have the ability to interact with caspase-3 and the potential to be used as prostate cancer drug candidates.
Co-Authors Amalia Hanifa, Zahra Aristokrat, Aria Diah Lia Aulifa Hanifah Hutapea, Ezra Calista Lia Aulifa, Diah Luthfiyah Rahmani, Syifa Muntashir, Ilham Mohammad Priana, Diva Dhaifina Mazaya Pribadi, Alya Puteri Agustina Puspitasari, Citra Dewi Puteri Agustina Pribadi, Alya Sriwidodo ., Sriwidodo Sudirman, Virgiana Keisha Rajabi Johni Widati Aqila Rumawan, Maritsa