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All Journal Acta Medical and Health Sciences (AMHS)
Ania K P Dewi
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Journal : Acta Medical and Health Sciences (AMHS)

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Potential of red guava fruitghurt in lowering blood glucose levels in streptozotocin induced rats Ania K P Dewi; Rona J H Dewi; Endry Septiadi
ACTA Medical Health Sciences Vol. 1 No. 1 (2022): ACTA Medical Health Sciences
Publisher : ACTA Medical Health Sciences

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Abstract

Diabetes mellitus is a chronic metabolic disorder characterized by increased blood glucose levels due to decreased insulin production, insulin action or both. Red guava fruitghurt contains flavonoid phytochemical compound. This research aims to determine the effect of red guava fruitghurt on reducing blood glucose levels in rats. The study was laboratory experiment. The subjects of this study were white rats (Rattus norvegicus) with wistar lines, where each group needed 5 rats, therefore the total was 25 rats. The sampling technique used is simple random sampling, The experimental animals are grouped into 5 groups, negative control, positive control, treatment 1 (administration of fruitghurt), treatment 2 (administration of glibenclamide), and treatment 3 (combination of fruitghurt and glibenclamide). The data analysis was performed with paired t test, one way anova, pairwise comparison test and post hoc duncan. The study found that red guava fruitghurt can reduce blood glucose levels in rats induced by streptozotocin and show a probability value or p value of 0.000 (p value < 0.05), meaning that there is a significant difference between Treatment 1, 2, and 3. The blood glucose level of rats after administration of fruitghurt was 75.4mg/dl, after administration of glibenclamide was 48.4mg/dl and the combination of fruitghurt and glibenclamide was 44.0mg/dl. From these data, it can be seen that the most influential treatment in reducing blood glucose levels is the combination of fruitghurt and glibenclamide. The significant effect in lowering blood glucose levels is the combination of fruitghurt and glibenclamide. DOI : 10.35990/amhs.v1n1.p19-27 REFERENCES Khairani, R. (2016). Prevalensi diabetes mellitus dan hubungannya dengan kualitas hidup lanjut usia di masyarakat. Universa Med, 26(1). Newman, W. A., & Kamus Saku Kedokteran Dorland. (2011). Kamus Saku Kedokteran Dorland (Ed. 28, Vol. 28). Djojoningrat, D. (2014). Buku Ajar Ilmu Penyakit Dalam (Edisi VI, Jilid I). Amir, S. M. J., Wungouw, H., & Pangemanan, D. (2015). Kadar glukosa darah sewaktu pada pasien diabetes melitus tipe 2 di Puskesmas Bahu Kota Manado. J e-Biomedik, 3(1). https://doi.org/10.35790/ebm.3.1.2015.6505 (2013). Global Status Report. NCD Executive Summary. New Dir Youth Dev, 2013(140). Kementerian Kesehatan Republik Indonesia. (2016). Mari Kita Cegah Diabetik Dengan Cerdik. (April 2015). Putra, J. S., Achmad, A., & Pramestutie, R. H. (2017). Kejadian efek samping potensial terapi obat anti diabetes pada pasien diabetes melitus berdasarkan algoritme Naranjo. Pharm J Indones, 2(2). https://doi.org/10.21776/ub.pji.2017.002.02.38 Rachmaniar, R., & Kartamihardja, H. (2016). Pemanfaatan sari buah jambu biji merah (Psidium guajava) sebagai antioksidan dalam bentuk granul effervescent. Indones J Pharm Sci Technol, 5(1). Labiba, N. M., Marjan, A. Q., & Nasrullah, N. (2020). Pengembangan soyghurt (yoghurt susu kacang kedelai) sebagai minuman probiotik tinggi isoflavon. Amerta Nutr, 4(3). https://doi.org/10.20473/amnt.v4i3.2020.244-249 Salimah, D. M., Lindriati, T., & Purnomo, B. H. (2015). Sifat fisik dan kimia puree jambu biji merah (Psidium guajava) dengan penambahan gum arab dan gum xanthan. J Agroteknologi, 09(02). Dewi, I. P., Septriani, R., Verawaty, V., & Mulyani, D. (2019). Daya antihiperglikemia yoghurt pada mencit putih jantan. J Katalisator, 4(2). https://doi.org/10.22216/jk.v4i2.4607 Shinta, A., & Kusuma, W. (2015). The effect of ethanol extract of soursop leaves (Annona muricata) to decreased levels of malondialdehyde. Vol 4. Nugraheni, A. A., Jaelani, M., Rahayuni, A., & Semedi, P. (2019). Efektifitas pemberian jus tomat dan jambu biji merah terhadap penurunan kolesterol total pada wanita overweight. J Ris GIZI, 7(2). https://doi.org/10.31983/jrg.v7i2.5121 Watanabe, D., Kuranuki, S., Sunto, A., Matsumoto, N., & Nakamura, T. (2018). Daily yogurt consumption improves glucose metabolism and insulin sensitivity in young nondiabetic Japanese subjects with type-2 diabetes risk alleles. Nutrients, 10(12). https://doi.org/10.3390/nu10121834 Arnanda, Q. P., & Nuwarda, R. F. (2019). Penggunaan radiofarmaka teknisium-99M dari senyawa glutation dan senyawa flavonoid sebagai deteksi dini radikal bebas pemicu kanker. Farmaka Suplemen, 14(1). Rezaei, M., Sanagoo, A., Jouybari, L., Behnampoo, N., & Kavosi, A. (2017). The effect of probiotic yogurt on blood glucose and cardiovascular biomarkers in patients with type II diabetes: A randomized controlled trial. Evid Based Care J, 6(4). https://doi.org/10.22038/ebcj.2016.7984 Wallace, B. Y. T. C., Velasco, A., Lay, T., et al. (2016). Pengaruh perbandingan jambu biji (Psidium guajava) dengan rosella (Hibiscus sabdariffa Linn) dan jenis jambu biji terhadap karakteristik jus. Bull Seismol Soc Am, 106(1). Novrial, D., Sulistyo, H., & Setiawati. (2013). Comparison of antidiabetic effects of honey, glibenclamide, metformin and their combination in the streptozotocin-induced diabetics rat. Semin Nas Kesehat Jur Kesehat Masy FKIK UNSOED. Lenzen, S. (2008). The mechanisms of alloxan- and streptozotocin-induced diabetes. Diabetologia, 51(2). https://doi.org/10.1007/s00125-007-0886-7 Saputra, N. T., Suartha, I. N., & Dharmayudha, A. A. G. O. (2018). Agen diabetagonik streptozotocin untuk membuat tikus putih jantan diabetes mellitus. Bul Vet Udayana. https://doi.org/10.24843/bulvet.2018.v10.i02.p02 Gomes, A. C., Bueno, A. A., De Souza, R. G. M. H., & Mota, J. F. (2014). Gut microbiota, probiotics and diabetes. Nutr J, 13(1). https://doi.org/10.1186/1475-2891-13-60 Sari, P. M. D. R. (2014). Studi literatur interaksi obat pada peresepan pasien diabetes melitus tipe 2 di instalasi rawat jalan RSUD Panembahan Senopati Bantul Yogyakarta periode Desember 2013. Fakultas Farmasi, Universitas Sanata Dharma Yogyakarta. König, A., Schwarzinger, B., Stadlbauer, V., et al. (2019). Guava (Psidium guajava) fruit extract prepared by supercritical CO₂ extraction inhibits intestinal glucose resorption in a double-blind, randomized clinical study. Nutrients, 11(7). https://doi.org/10.3390/nu11071512 Nilamaya, F. A. (2018). Pengaruh variasi konsentrasi perisa sari jambu biji merah (Psidium guajava) terhadap tingkat kesukaan panelis dan kandungan vitamin C pada yoghurt susu UHT (Ultra High Temperature). [Skripsi]. Rifdiyani, F. A. (2018). Pengaruh pemberian bakteri asam laktat Dangke jenis Lactobacillus plantarum dan Enterococcus faecium terhadap kadar glukosa darah mencit (Mus musculus) ICR jantan. [Skripsi].
The relationship between menstrual cycle and psychological stress on acne vulgaris incidence Ania K P Dewi; Rina Munirah B; Westinawati Rahman H
ACTA Medical Health Sciences Vol. 3 No. 1 (2024): Acta Medical and Health Sciences
Publisher : ACTA Medical Health Sciences

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Abstract

Acne vulgaris (AV) is a chronic inflammation of the pilosebaceous unit and presents with a polymorphic clinical picture such as comedones, papules, pustules, nodules, and scars. AV is often experienced by both women and men, affecting 85% of young adults aged 12-25 years, with women more commonly affected than men. There are several triggers that contribute to the onset of AV, including the menstrual cycle and psychological stress. This study aims to determine the relationship between the menstrual cycle, psychological stress, and the occurrence of acne vulgaris in female medical students at Universitas Jenderal Achmad Yani. The research design uses a cross-sectional study approach. There were 48 people who met the inclusion criteria. Respondents in this study were asked to fill out informed consent forms, questionnaires, and indicate their availability for standardized facial photos. The results of this study obtained a p-value of 1.000 and 0.529 (p-value > 0.05). It was found that there is no statistically significant association observed between either regular menstrual cycles or severe psychological stress and the presence of acne vulgaris in this sample. The odds ratios for both variables (1.052 and 1.303) suggest minor increases in the odds of acne vulgaris presence, but they do not reach statistical significance. This relates to the occurrence of acne vulgaris, which is not only caused by factors such as the menstrual cycle and psychological stress but also by various triggering factors including diet, use of cosmetics, facial hygiene, and unhealthy sleep patterns. DOI : 10.35990/amhs.v3n1.p51-59 REFERENCES Li D, Chen Q, Liu Y, Tang W, Li S. The Prevalence of Acne in Mainland China: a systematic review and meta-analysis. BMJ Open. 2017;7(8). Agesti D, Astuti S, Mustika A. Penanganan Jerawat Sindrom Akumulasi Dahak Menggunakan Akupunktur dan Herbal Jianghuang. J Vocational Health Studies. 2020;4:15–20. Jusuf NK, Putra IB, Sutrisno AR. Correlation Between Stress Scale and Serum Substance P Level in Acne Vulgaris. Int J Gen Med. 2021;14:681–686. Heng AH, Chew F. Systematic Review of the Epidemiology of Acne Vulgaris. Scientific Reports. 2020;10:5754. Sutaria AH, Masood S, Saleh HM, Schlessinger J. Acne Vulgaris. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Aug 6. Available from: https://www.ncbi.nlm.nih.gov/books/NBK459173/ Fadilah AA. Stres Psikologis Terhadap Timbulnya Akne Vulgaris. J Ilmu Kesehatan Sandi Husada. 2021;10:390–391. Wijayanti N, Diana ED, Irawanto ME. Hubungan Tingkat Stres dengan Derajat Keparahan Akne. Health Med J. 2023;5:39–43. Sirajudin A, Sibero HT, Anggraini DI. Prevalensi dan Gambaran Epidemiologi Akne Vulgaris di Provinsi Lampung. JK Unila. 2019;3:308–312. Lestari RT, Gifanda LZ, Kurniasari EL, Harwiningrum RP, Kelana AP, Fauziyah K, et al. Perilaku Mahasiswa Terkait Cara Mengatasi Jerawat. J Farm Komunitas. 2021;8:15–19. Hartono LM, Kapantow MG, Kairupan TS. 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Co-Authors Endry Septiadi Rina Munirah B Rona J H Dewi Westinawati Rahman H