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DIET MEDITERANIA MENURUNKAN INDEKS MASSA TUBUH, LINGKAR PINGGANG, DAN KADAR LEMAK PADA PASIEN OBESITAS Endry Septiadi; Andri Andrian Rusman; Dewi Ratih Handayani; Iis Inayati Rakhmat; Nur Muhamad Rohman; Achmad Hero Prawira; Muhammad Akmal Rais; Rifal Aldi Anugrah
Medika Kartika : Jurnal Kedokteran dan Kesehatan Vol 4 No 3 (2021): Medika Kartika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran Universitas Jenderal Achmad Yani

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Obesitas adalah suatu keadaan berlebihnya deposit lemak tubuh yang ditandai dengan indeks massa tubuh (IMT) lebih dari 25 kg/m2. Obesitas dapat terjadi karena ketidakseimbangan pemasukan dan pengeluaran energi yang membuat berat badan, lingkar pinggang, dan kadar lemak meningkat. Diet Mediterania yang merekomendasikan konsumsi tinggi MUFA dan PUFA serta penurunan konsumsi karbohidrat menjadi diet yang direkomendasikan untuk pasien obesitas. Penelitian ini bertujuan untuk mengetahui hubungan lama diet Mediterania dengan IMT, lingkar pinggang, dan kadar lemak pada peserta Prolanis Klinik Healthy Life yang mengalami obesitas. Metode penelitian ini bersifat analitik dengan pengamatan secara kohort. Pengambilan sampel dilakukan dengan consecutive sampling. Subjek pada penelitian ini adalah 59 pasien obesitas yang terbagi atas kelompok berdasarkan durasi diet Mediterania, yaitu kelompok satu bulan (K1), dua bulan (K2), dan tiga bulan (K3), yang dilakukan pemeriksaan IMT, lingkar pinggang, dan kadar lemak pada akhir setiap bulannya. Data hasil penelitian dianalisis menggunakan uji Anova dilanjutkan dengan Post Hoc Duncan untuk mengetahui perbandingan setiap kelompok. Indeks massa tubuh, lingkar pinggang, dan kadar lemak mengalami penurunan yang signifikan dan progresif dengan bulan ketiga menunjukkan rata-rata penurunan yang paling baik yaitu sebesar 1,41 kg/m2 dengan nilai p=0,000 untuk IMT, rata-rata penurunan sebesar 6,58 cm dengan nilai p=0,000 untuk lingkar pinggang dan rata-rata penurunan yang paling baik yaitu sebesar 3,52% dengan nilai p=0,026 untuk kadar lemak. Lama diet Mediterania terbukti memengaruhi penurunan IMT, lingkar pinggang, dan kadar lemak secara signifikan pada pasien obesitas. Hasil penelitian ini mendukung hipotesis bahwa terdapat hubungan lama diet Mediterania dengan penurunan IMT, lingkar pinggang, dan kadar lemak. Kata Kunci: Diet Mediterania, Indeks Massa Tubuh, Kadar Lemak, Lingkar Pinggang, Obesitas DOI : 10.35990/mk.v4n3.p256-266

EFEK EKSTRAK ETANOL DAUN PETAI CINA (Leucaena glauca. Benth.) TERHADAP FUNGSI DAN GAMBARAN HISTOPATOLOGIS HATI TIKUS (Rattus novergicus) GALUR WISTAR MODEL FIBROSIS HATI Ardella Tri Novianti; Endry Septiadi; Vita Murniati Tarawan; Andri Rezano; Achadiyani Achadiyani
Medika Kartika : Jurnal Kedokteran dan Kesehatan Vol 1 No 1 (2017): Medika Kartika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran Universitas Jenderal Achmad Yani

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Kerusakan hati kronis berkaitan kerusakan sel hati, aktifnya sel stelat, akumulasi protein matriks ekstraselular, dan menyebabkan fibrosis hati. Petai cina (Leucaena glauca, Benth.) secara empiris digunakan untuk mengobati penyakit hati. Daun petai cina mengandung antioksidan dan zat aktif seperti tanin, saponin, alkaloid, dan saponin yang dapat membantu perbaikan fungsi hati pada fibrosis. Penelitian ini bertujuan menganalisis efek ekstrak etanol daun petai cina terhadap perbaikan fungsi dan histolopatologis hati tikus model fibrosis. Kelompok uji dibagi menjadi kontrol negatif yang diberi aquades, kelompok perlakuan 1, 2 dan 3 diberikan ekstrak etanol daun petai cina selama 14 hari dengan dosis 2,25; 4,5 dan 9 mg/200gBB. Uji Analisis data SGOT, SGPT, dan jumlah sel hepatosit normal menggunakan ANOVA, dilanjutkan dengan uji a Scheffe. Data perubahan derajat fibrosis menggunakan uji Kruskall-Wallis dan dilanjutkan uji Mann Whitney. Terdapat perbedaan signifikan kelompok perlakuan dengan kelompok kontrol terhadap penurunan kadar SGOT (p=0,001), SGPT (p=0,000), peningkatan jumlah hepatosit normal (p=0,000), dan penurunan derajat fibrosis (p=0,04). Hasil uji Krusskall Wallis menunjukkan derajat fibrosis pada kelompok kontrol berbeda bermakna (p=0,04) dengan kelompok perlakuan. Hasil uji Mann Whitney menunjukkan derajat fibrosis pada kelompok kontrol berbeda bermakna (p<0,05) dengan kelompok perlakuan 3 (p=0,015). Ekstrak etanol daun petai cina (Leucaena glauca,Benth.) memiliki efek memperbaiki fungsi hati dengan menurunkan kadar SGOT dan SGPT, meningkatkan proliferasi sel hati yang normal, serta menurunkan derajat fibrosis. DOI : 10.35990/mk.v1n1.p1-14

PERBEDAAN TINGKAT KEPATUHAN DIET MEDITERANIA TERHADAP TEKANAN DARAH PADA PASIEN HIPERTENSI Yudith Yunia Kusmala; Endry Septiadi; Dewi Ratih Handayani; Iis Inayati Rakhmat; Lukman Tobing; Zacky Muttaqien Putra Nandita; Rifky Atha'ullah Nuralif
Medika Kartika : Jurnal Kedokteran dan Kesehatan Vol 6 No 1 (2023): Medika Kartika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran Universitas Jenderal Achmad Yani

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Data World Health Organization (WHO) menetapkan pasien hipertensi di seluruh dunia yaitu sekitar 1,13 milyar orang. Riset Kesehatan Dasar (Riskesdas) 2018 menunjukkan bahwa prevalensi pasien hipertensi mencapai 34,1% di Indonesia, di Provinsi Jawa Barat sebesar 39,6%, dan di Kota Cimahi sebesar 41,83%. Salah satu penatalaksanaan hipertensi yang direkomendasikan oleh US Dietary Guideline, American Heart Association (AHA), dan European Society of Cardiology (ESC) adalah diet Mediterania. Penelitian ini bertujuan untuk mengetahui perbedaan tingkat kepatuhan diet Mediterania terhadap tekanan darah sistolik, diastolik, dan mean arterial pressure (MAP) pada pasien hipertensi. Rancangan penelitian menggunakan metode analitik observasional dengan pengamatan kohort prospektif pada 39 pasien hipertensi selama satu bulan. Pengambilan data sampel menggunakan teknik systematic random sampling. Subjek penelitian terbagi berdasarkan kepatuhan diet Mediterania yaitu rendah, sedang, dan tinggi yang diukur dengan skor alternate Mediterranean diet (AMED) setelah mengisi food frequency questionnaire (FFQ) 4 kali dalam 1 bulan, kemudian dilakukan pemeriksaan tekanan darah pada akhir bulan. Data tekanan darah sistolik dan MAP dilakukan uji analisis Anova dan Post Hoc Tukey, sedangkan data tekanan darah diastolik dilakukan uji Kruskal Wallis dan Mann Whitney. Hasil penelitian menunjukkan perbedaan tingkat kepatuhan diet Mediterania terhadap tekanan darah sistolik (p=0,001<0,05), tekanan darah diastolik (p=0,029<0,05), dan MAP (p=0,003<0,05) yang bermakna pada pasien hipertensi. Semakin tinggi tingkat kepatuhan pasien dalam menjalankan diet Mediterania, maka nilai tekanan darah sistolik, diastolik, dan MAP semakin rendah. Komposisi diet Mediterania yang mengandung monounsaturrated fatty acid (MUFA) dan polyunsaturated fatty acid (PUFA) yang tinggi berefek sebagai antiinflamasi, antioksidan, dan kardioprotektif sehingga berpotensi menurunkan tekanan darah. Kata kunci : diastolik, diet mediterania, kepatuhan, mean arterial pressure, sistolik DOI : 10.35990/mk.v6n1.p22-33

Differences in Mediterranean diet adherence on lipid profile and plasma atherogenic index in dyslipidemia patients Dewi R Handayani; Khomaini Hasan; Iis I Rakhmat; Endry Septiadi; Yudith Y Kusmala
ACTA Medical Health Sciences Vol. 1 No. 1 (2022): ACTA Medical Health Sciences
Publisher : ACTA Medical Health Sciences

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Dyslipidemia is a lipid metabolism disorder characterized by an increase in total cholesterol, triglycerides, and Low-Density Lipoprotein (LDL), as well as a decrease in High-Density Lipoprotein (HDL). According to the 2018 Basic Health Research (Riset Kesehatan Dasar/RISKESDAS), 12.6% of the Indonesian population aged 55–64 years had high cholesterol levels along with very high LDL and triglyceride levels. The Mediterranean diet is a form of non-pharmacological therapy involving nutritional intervention for patients with dyslipidemia. This study aimed to examine the effect of adherence to the Mediterranean diet on lipid profiles and the Plasma Atherogenic Index (PAI) in dyslipidemic patients at a private clinic in Bandung. This research employed an observational analytic method with a prospective cohort design involving 30 patients with dyslipidemia. Subjects were selected using a systematic random sampling technique and categorized into three groups based on their adherence to the Mediterranean diet: low, medium, and high. At the end of the month, lipid profile parameters and PAI were measured. Data on total cholesterol, LDL, and HDL levels were analyzed using ANOVA and Tukey’s Post Hoc test, while triglycerides and PAI were analyzed using the Kruskal-Wallis and Mann-Whitney tests. The results showed significant differences in total cholesterol (p = 0.007), LDL (p = 0.019), HDL (p = 0.006), triglycerides (p = 0.005), and PAI (p = 0.036) across the adherence groups. These findings suggest that higher adherence to the Mediterranean diet is associated with improvements in lipid profile and PAI. The beneficial effects are likely due to the diet’s rich content of monounsaturated fatty acids (MUFA), polyunsaturated fatty acids (PUFA), phytosterols, and polyphenols, which positively influence lipid metabolism and reduce atherogenic risk. DOI : 10.35990/amhs.v1n1.p1-9 REFERENCES Jameson JL. Harrison’s Principles of Internal Medicine. Edisi ke-19. Kasper DL, editor. New York: McGraw-Hill; 2015. hlm. 2438. John MF, Adam. Dislipidemia. Dalam: Sudoyo AW, dkk., editor. Buku Ajar Penyakit Dalam. Edisi IV. Jakarta: Balai Penerbit Departemen Ilmu Penyakit Dalam FKUI; 2006. hlm. 2554. Gebreegziabiher G, Belachew T, Mehari K, Tamiru D. Prevalence of dyslipidemia and associated risk factors among adult residents of Mekelle City, Northern Ethiopia. PLoS One. 2021;16:1–18. Qi L, Ding X, Tang W, Li Q, Mao D, Wang Y. Prevalence and risk factors associated with dyslipidemia in Chongqing, China. Int J Environ Res Public Health. 2015;12(10):13455–65. Roslaeni R, Sundari R, Baswedan MH. Gambaran Risiko Penyakit Jantung Koroner Berdasarkan Rasio Profil Lipid Pada Usia Dewasa Muda. Med Kartika J Kedokt dan Kesehat. 2019;2(2):110–22. Millán J, Pintó X, Muñoz A, Zúñiga M, Rubiés-Prat J, Pallardo LF, et al. Lipoprotein ratios: Physiological significance and clinical usefulness in cardiovascular prevention. Vasc Health Risk Manag. 2009;5:757–65. Arsana PM, Rosandi R, Manaf A, Budhiarta A, Permana H. Pedoman Pengelolaan Dislipidemi di Indonesia 2019. PB PERKENI; 2019. hlm. 9. Perhimpunan Dokter Spesialis Kardiovaskular Indonesia. Panduan Tatalaksana Dislipidemia. 2017. Van Horn L, Carson JAS, Appel LJ, Burke LE, Economos C, Karmally W, et al. Recommended dietary pattern to achieve adherence to the AHA/ACC Guidelines: A scientific statement from the American Heart Association. Circulation. 2016;134(22):505–29. Liyanage T, Ninomiya T, Wang A, Neal B, Jun M, Wong MG, et al. Effects of the Mediterranean diet on cardiovascular outcomes: A systematic review and meta-analysis. PLoS One. 2016;11(8). Anggraini DI, Labibah Z. Diet Mediterania dan Manfaatnya terhadap Kesehatan Jantung dan Kardiovaskular. J Major. 2016;5(3):1–3. Jacobs S, Harmon BE, Ollberding NJ, Wilkens LR, Monroe KR, Kolonel LN, et al. Among 4 diet quality indexes, only the alternate Mediterranean diet score is associated with better colorectal cancer survival and only in African American women in the Multiethnic Cohort. J Nutr. 2016;146(9):1746–55. Tian HY, Qiu R, Jing LP, Chen ZY, Chen GD, Chen YM. Alternate Mediterranean diet score is positively associated with skeletal muscle mass index in middle-aged adults. Br J Nutr. 2017;117(8):1181–8. Shvetsov YB, Harmon BE, Ettienne R, Wilkens LR, Le Marchand L, Kolonel LN, et al. The influence of energy standardisation on the alternate Mediterranean diet score and its association with mortality in the Multiethnic Cohort. Br J Nutr. 2016;116(9):1592–601. Feng L, Nian S, Tong Z, Zhu Y, Li Y, Zhang C, et al. Age-related trends in lipid levels: A large-scale cross-sectional study of the general Chinese population. BMJ Open. 2020;10(3):e034226. Liu HH, Li JJ. Aging and dyslipidemia: A review of potential mechanisms. Ageing Res Rev. 2015;19:43–52. DG I, Shetty S, Rao AV, Ahmad S. Age-related difference in the lipid profile in normal healthy women. J Health Allied Sci NU. 2014;4(2):94–7. Palmisano BT, Zhu L, Stafford JM. Role of estrogens in the regulation of liver lipid metabolism. In: Advances in Experimental Medicine and Biology. Vol. 1043. 2017. hlm. 227–56. Schwingshackl L, Morze J, Hoffmann G. Mediterranean diet and health status: Active ingredients and pharmacological mechanisms. Br J Pharmacol. 2020;177(6):1241–57. Poli A, Marangoni F, Corsini A, Manzato E, Marrocco W, Martini D, et al. Phytosterols, cholesterol control, and cardiovascular disease. Nutrients. 2021;13(8):1–13. Castro-Barquero S, Lamuela-Raventós RM, Doménech M, Estruch R. Relationship between Mediterranean dietary polyphenol intake and obesity. Nutrients. 2018;10(10):1–13. Ferro Y, Mazza E, Salvati M, Santariga E, Giampà S, Spagnuolo R, et al. Effects of a portfolio-Mediterranean diet and a Mediterranean diet with or without a sterol-enriched yogurt in individuals with hypercholesterolemia. Endocrinol Metab. 2020;35(2):298–307. Hannon BA, Thompson SV, An R, Teran-Garcia M. Clinical outcomes of dietary replacement of saturated fatty acids with unsaturated fat sources in adults with overweight and obesity: A systematic review and meta-analysis of randomized control trials. Ann Nutr Metab. 2017;71:107–17. Hernáez Á, Fernández-Castillejo S, Farràs M, Catalán Ú, Subirana I, Montes R, et al. Olive oil polyphenols enhance high-density lipoprotein function in humans: A randomized controlled trial. Arterioscler Thromb Vasc Biol. 2014;34(9):2115–9. Grao-Cruces E, Varela LM, Martin ME, Bermudez B, Montserrat-De la Paz S. 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Potential of red guava fruitghurt in lowering blood glucose levels in streptozotocin induced rats Ania K P Dewi; Rona J H Dewi; Endry Septiadi
ACTA Medical Health Sciences Vol. 1 No. 1 (2022): ACTA Medical Health Sciences
Publisher : ACTA Medical Health Sciences

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Diabetes mellitus is a chronic metabolic disorder characterized by increased blood glucose levels due to decreased insulin production, insulin action or both. Red guava fruitghurt contains flavonoid phytochemical compound. This research aims to determine the effect of red guava fruitghurt on reducing blood glucose levels in rats. The study was laboratory experiment. The subjects of this study were white rats (Rattus norvegicus) with wistar lines, where each group needed 5 rats, therefore the total was 25 rats. The sampling technique used is simple random sampling, The experimental animals are grouped into 5 groups, negative control, positive control, treatment 1 (administration of fruitghurt), treatment 2 (administration of glibenclamide), and treatment 3 (combination of fruitghurt and glibenclamide). The data analysis was performed with paired t test, one way anova, pairwise comparison test and post hoc duncan. The study found that red guava fruitghurt can reduce blood glucose levels in rats induced by streptozotocin and show a probability value or p value of 0.000 (p value < 0.05), meaning that there is a significant difference between Treatment 1, 2, and 3. The blood glucose level of rats after administration of fruitghurt was 75.4mg/dl, after administration of glibenclamide was 48.4mg/dl and the combination of fruitghurt and glibenclamide was 44.0mg/dl. From these data, it can be seen that the most influential treatment in reducing blood glucose levels is the combination of fruitghurt and glibenclamide. The significant effect in lowering blood glucose levels is the combination of fruitghurt and glibenclamide. DOI : 10.35990/amhs.v1n1.p19-27 REFERENCES Khairani, R. (2016). Prevalensi diabetes mellitus dan hubungannya dengan kualitas hidup lanjut usia di masyarakat. Universa Med, 26(1). Newman, W. A., & Kamus Saku Kedokteran Dorland. (2011). Kamus Saku Kedokteran Dorland (Ed. 28, Vol. 28). Djojoningrat, D. (2014). Buku Ajar Ilmu Penyakit Dalam (Edisi VI, Jilid I). Amir, S. M. J., Wungouw, H., & Pangemanan, D. (2015). Kadar glukosa darah sewaktu pada pasien diabetes melitus tipe 2 di Puskesmas Bahu Kota Manado. J e-Biomedik, 3(1). https://doi.org/10.35790/ebm.3.1.2015.6505 (2013). Global Status Report. NCD Executive Summary. New Dir Youth Dev, 2013(140). Kementerian Kesehatan Republik Indonesia. (2016). Mari Kita Cegah Diabetik Dengan Cerdik. (April 2015). Putra, J. S., Achmad, A., & Pramestutie, R. H. (2017). Kejadian efek samping potensial terapi obat anti diabetes pada pasien diabetes melitus berdasarkan algoritme Naranjo. Pharm J Indones, 2(2). https://doi.org/10.21776/ub.pji.2017.002.02.38 Rachmaniar, R., & Kartamihardja, H. (2016). Pemanfaatan sari buah jambu biji merah (Psidium guajava) sebagai antioksidan dalam bentuk granul effervescent. Indones J Pharm Sci Technol, 5(1). Labiba, N. M., Marjan, A. Q., & Nasrullah, N. (2020). 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Daily yogurt consumption improves glucose metabolism and insulin sensitivity in young nondiabetic Japanese subjects with type-2 diabetes risk alleles. Nutrients, 10(12). https://doi.org/10.3390/nu10121834 Arnanda, Q. P., & Nuwarda, R. F. (2019). Penggunaan radiofarmaka teknisium-99M dari senyawa glutation dan senyawa flavonoid sebagai deteksi dini radikal bebas pemicu kanker. Farmaka Suplemen, 14(1). Rezaei, M., Sanagoo, A., Jouybari, L., Behnampoo, N., & Kavosi, A. (2017). The effect of probiotic yogurt on blood glucose and cardiovascular biomarkers in patients with type II diabetes: A randomized controlled trial. Evid Based Care J, 6(4). https://doi.org/10.22038/ebcj.2016.7984 Wallace, B. Y. T. C., Velasco, A., Lay, T., et al. (2016). Pengaruh perbandingan jambu biji (Psidium guajava) dengan rosella (Hibiscus sabdariffa Linn) dan jenis jambu biji terhadap karakteristik jus. Bull Seismol Soc Am, 106(1). Novrial, D., Sulistyo, H., & Setiawati. (2013). 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Differences in mediterranean diet adherence on bmi, waist circumference, fat percentage, muscle mass in obesity Endry Septiadi; Dinar Mutiara; Henny Juliastuti; Iis I Rakhmat; Dewi R Handayani
ACTA Medical Health Sciences Vol. 1 No. 1 (2022): ACTA Medical Health Sciences
Publisher : ACTA Medical Health Sciences

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Obesity is a multifactorial disease that occurs when there is an abnormal accumulation of body fat due to an imbalance between energy intake and energy expenditure. The prevalence of Riset Kesehatan Dasar in 2018 showed that 21.8% of the Indonesian population over 18 years is obese. One of the diets recommended by European Association for the Study of Obesity Community for obesity is the Mediterranean diet. This study aims to determine the difference of adherence level in the Mediterranean diet to nutritional status, and muscle mass in obese patients. The method used in this study is analytic observational with prospective cohort observations. Subjects in this study were 37 obese patients who were monitored for diet four times in one month with food frequency questionnaire and checked for BMI, waist circumference, body fat percentage, and muscle mass at the end of the month. BMI and body fat percentage were analyzed using the Anova test while waist circumference and muscle mass data were analyzed using the Kruskal Wallis test. The level of adherence to the Mediterranean diet has been shown to significantly affect BMI (p=0.008), waist circumference (p=0.042), body fat percentage (p=0.014), and muscle mass (p=0.009) in obese patients. This associated with the composition of Mediterranean diet which affects increase in thermogenesis, fat oxidation, anti-inflammatory, and increases satiety for a longer period. The results of this study support the hypothesis that there is the difference of adherence to the Mediterranean diet to nutritional status and muscle mass in obese patients. DOI : 10.35990/amhs.v1n1.p28-37 REFERENCES Sugondo S, Purnamasari D. Obesitas. Dalam: Setiati S, Alwi I, Sudoyo AW, editors. Buku Ajar Ilmu Penyakit Dalam. 6th ed. Jakarta: InternaPublishing; 2014. Chooi YC, Ding C, Magkos F. The epidemiology of obesity. Metabolism. 2019;92:p6–10. 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Characterisctics, Clinical Features, And Management Of Fibroadenoma Mammae Patients At Dustira Hospital Cimahi Ris Kristiana; Salsha Regina Syakyra; Endah Hamidah; Endry Septiadi; Fitriardi Sejati; Tatang Bisri
Jurnal EduHealth Vol. 16 No. 01 (2025): Jurnal EduHealt, Edition January - March, 2025
Publisher : Sean Institute

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Fibroadenoma mammae (FAM) is the most common benign breast tumor that occurs at the age of 14-35 years. About 10% of the female population has FAM. FAM manifests as solitary masses that are easily movable, well-defined, with a smooth surface. The aim of this study was to determine the characteristics, clinical features, and management of FAM patients at Dustira Hospital using secondary data from medical records. A total of 68 FAM patients were selected as samples during the period 2018-2023. The research variables consisted of the number of cases, age, body mass index(BMI), location, topography, size, quantity, and management of FAM. Univariate analysis was used in this study and the results were presented in narrative and tabular forms. The results of the study showed that the highest number of FAM cases occurred in 2018, reaching 28 (41.1%). Characteristics of FAM patients included 49 individuals (72%) in the 16-30 age group, 32 individuals (47%) with normal body mass index. Clinical features of FAM were found in 31 individuals (45.6%) on the right breast, 24 individuals (35.3%) in the upper medial quadrant, with a size of 3-5 cm in 24 individuals (35.3%), and 49 individuals ( 72.1%) limited solitary masses. Management included surgery in all 68 individuals (100%), with 67 individuals (98.5%) underwent excision, while 1 individual (1.5%) underwent incision. Age and BMI are suspected to play a role in FAM formation related to estrogen hypersensitivity and mutations in the mediator complex subunit 12 (MED12). Lesion size is influenced by estrogen exposure. Management of fibroadenoma depends on the patient's preferences and clinical conditions. Women at risk or suspecting breast masses are advised to perform self-breast examination (BSE) and efficiently consult with healthcare professionals.

Phytochemical Features of Moringa oleifera Leaves as Anticancer Ludovicus Edwinanto; Endry Septiadi; Latifah R. Nurfazriah; Karina S. Anastasya; Natallia Pranata
Journal of Medicine and Health Vol 2 No 1 (2018)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v2i1.745

Cancer is a disease that can threaten human life. Various methods of cancer therapy havebeen widely practiced, one of which is chemotherapy. But the cost used for the therapy is alsovery expensive. This difficulty led many researchers to conduct research to find activecompounds from natural materials. Moringa leaf (Moringa oleifera) has cytotoxic activity,because it contains a lot of flavonoids. Flavonoids are polyphenol compounds produced fromsecondary metabolism in plants. The most flavonoids that are anticancer active substances inthe Moringa leaf are quercetin, kaempferol and myricetin. Cytotoxic activity because theseactive substances can induce apoptosis through intrinsic pathways by inhibition of mitogen-activated protein kinase (MAPK), extracellular-signal-regulated kinase 1/2 (ERK 1/2), c-Jun N-terminal protein kinase 1 (JNK), and protein kinase C (PKC).Keywords: Moringa leaf, quersetin; kaempferol; myricetin; anticancer

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