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All Journal Nusantara Scientific Medical Research Journal PCJN Pharmaceutical and Clinical Journal of Nusantara
Dodikrisno Ekaputra Manery
Faculty of Medicine, Pattimura University, Ambon
Dentistry Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Improved Quality of Spermatozoa Mice (Mus musculus) Model of Diabetes Mellitus Type 1 After Being Given Cinnamon Bark Methanol Extract (Cinnamomum burmanii Bl.) Abdul M Ukratalo; Titus Frendi Wedilen; Ian Risaldy Tofure; Dodikrisno Ekaputra Manery; Muhammad Reza Ramadhany
NSMRJ: Nusantara Scientific Medical Research Journal Vol. 1 No. 1 (2022): NSMRJ: Nusantara Scientific Medical Research Journal
Publisher : Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (433.047 KB) | DOI: 10.58549/nsmrj.v1i1.27

Abstract

Diabetes mellitus has to do with male fertility, a hormone disorder that affects spermatogenesis. This study aims to determine the effect of cinnamon bark methanol extract (Cinnamomum burmani) on the quality of diabetes mellitus mice spermatozoa. This study used a complete randomized design with 4 treatments and 3 repeats. 22 mice were divided into 4 groups. Mice have injected with streptozotocin dose of 0.1 mL and observed blood sugar levels were, if sugar levels increased, they are given cinnamon bark methanol extract at a dose of 250 mg/kg BB and 500 mg/kg BB, and blood sugar levels are measured. After that, the mice are dissected for observation of spermatozoa's morphology, viability, and motility after administration of the extract. The results showed that cinnamon bark methanol extract at a dose of 250 mg/kg BB and 500 mg/kg BB can reduce the number of abnormal spermatozoa and increase the viability and motility of diabetes mellitus mice spermatozoa. This indicates that cinnamon bark extract as an antioxidant has a positive effect in maintaining structure and development, as well as the function of spermatogenesis cells so that in the presence of these active substances, the number of seed cells that experience developmental failure, degeneration, death due to free radicals can be suppressed or reduced.
Potential Bark Cinnamomum burmanii in Regenerating Damaged Liver Cells of Mice (Mus musculus) Diabetes Mellitus Model Abdul M Ukratalo; Martha Kaihena; Dion P O Sirait; Nadira Pattimura; Dodikrisno Ekaputra Manery
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 2 No. 01 (2023): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (752.864 KB) | DOI: 10.58549/pcjn.v2i01.58

Abstract

Diabetes mellitus is a chronic disease that can quickly increase the prevalence of complications in sufferers, such as liver damage. This study aims to examine the effect of methanol extract cinnamon bark (Cinnamomum burmanii Bl) in regenerating liver cell damage mice (Mus musculus) Diabetes Mellitus through the histological picture. 20 mice were divided into 5 groups which consisted of a negative control group, Positive control and a group of mice that were given methanol extract bark Cinnamomum burmannii dose of 125 mg/head/day, 250 mg/head/Day and 500 mg/head/day. In the positive control group and the group of mice that will be given extract streptozotocin injected dose of 0.2 ml and observed blood sugar levels if sugar levels have increased then given methanol extract bark Cinnamomum burmannii with a dose that has been determined and blood sugar levels were measured. On the last day, surgery is performed to remove the liver, after which histological preparations are made. The results showed that the administration of bark extract Cinnamomum burmanii can regenerate damaged liver cells of mice due to diabetes mellitus. This is due to the content of secondary metabolite compounds contained in the bark of Cinnamomum burmannii.
Co-Authors Abdul M Ukratalo Dion P O Sirait Ian Risaldy Tofure Martha Kaihena Muhammad Reza Ramadhany Nadira Pattimura Titus Frendi Wedilen