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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Journal of Medical Studies
Sri Yusfinah Masfah Hanum
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Other

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EVALUASI SURVIVIN DAN MAMMALIAN TARGET OF RAPAMYCIN COMPLEX-1 SERTA KORELASINYA PADA AKNE VULGARIS Mirna Marhami Iskandar; Sri Yusfinah Masfah Hanum; Erny Kusdiah; Rima Rahmi Putri Harahap; Jelica Oktaviani
Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Vol. 11 No. 1 (2023): Jambi Medical Journal: Jurnal Kedokteran dan Kesehatan
Publisher : FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/jmj.v11i1.21121

Abstract

Background: Survivin is a member of the apoptosis inhibitory protein family, a protein molecule important for the regulation of mitosis and inhibition of apoptosis and also plays a role in certain physiological processes and pathological conditions such as carcinogenesis in human cells/organs. Several studies have shown that survivin plays a role in the pathogenesis of acne vulgaris and post-inflammatory acne scarring. Mammalian target of rapamycin complex-1 (mTORC1) is a regulator of cell growth, proliferation and metabolic homeostasis, and mTORC1 signaling regulates survivin via the kinase pathway. Objectives: This study aimed to assess the correlation of survivin levels with mTORC1 and the severity of acne vulgaris. Methods: This research was a cross-sectional study. Venous blood samples of mild, moderate, and severe AV patients were 20 people each, ELISA examination was performed. Result: The results showed that serum levels of survivin and mTORC1 had a correlation with the severity of AV (p<0.05), while the correlation between survivin and mTORC1 was not significant (p>0.05). Conclussion: This study proves that increased survivin and mTORC1 are associated with increased severity of acne vulgaris, but the relationship between survivin and mTORC1 needs further investigation. Key words: survivin, mammalian target of rapamycin complex-1, akne vulgaris
The Correlation Between The Severity Of Acne Vulgaris And Quality Of Life Using The Cardiff Acne Disability Index (CADI) Questionnaire At Zaira Skin Care Main Clinic In Jambi City Fairuza, Putri Azka; Sri Yusfinah Masfah Hanum; Mirna Marhami Iskandar; Fitriyanti; Ahmad Syauqy
Journal of Medical Studies Vol. 5 No. 2 (2025): Journal of Medical Studies
Publisher : Fakultas Kedokteran dan Ilmu Kesehatan Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/joms.v5i2.40452

Abstract

ABSTRACT Background: Acne Vulgaris (AV) is a skin condition characterized by chronic inflammation. The degree of AV used in this study is based on the Lehmann criteria. The quality of life in this study was measured using the CADI questionnaire. The CADI questionnaire is used to assess quality of life specifically for individuals with Acne Vulgaris. Objective: To determine whether there is a relationship between the degree of AV and the quality of life of AV patients who seek treatment at Zaira Skin Care Clinic, Jambi City. Methods: Of the 97 respondents, 43 respondents (44.3%) had mild AV, with 23 respondents (23.7%) experiencing mild quality of life disturbances, 16 respondents (16.5%) experiencing severe quality of life disturbances, and 4 respondents (4.1%) experiencing very severe quality of life disturbances. In the moderate AV group, consisting of 45 respondents, 13 respondents (13.4%) had mild quality of life disturbances, 24 respondents (24.74%) had moderate disturbances, and 8 respondents (8.25%) had severe disturbances. In the severe AV group, consisting of 9 respondents, 2 respondents (2.06%) experienced moderate quality of life disturbances, and 7 respondents (7.22%) had severe disturbances. The data from the Kendall-tau test analysis showed a significant result with p = 0.001 (p < 0.05), and a correlation coefficient of 0.381. This indicates a positive and moderately significant relationship. Results: The data from the Kendall-tau test analysis showed a significant result with p = 0.001 (p < 0.05) and a correlation coefficient is 0.381. This indicates a positive and moderately significant relationship. Conclusion: There is a relationship between the degree of AV severity and the quality of life of AV patients. Keywords: Acne Vulgaris, AV severity, quality of life, CADI
Co-Authors Ahmad Syauqy Erny Kusdiah Fairuza, Putri Azka Fitriyanti Iskandar, Mirna Marhami Jelica Oktaviani Rima Rahmi Putri Harahap