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All Journal Window of Health : Jurnal Kesehatan Jurnal Ilmiah Sultan Agung
Titiek Sumarawati
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Religion Humanities Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Electrical & Electronics Engineering Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health

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Hubungan Atherosclerotic Cardiovascular Disease Score dengan derajat stenosis berdasarkan gensini score Nisya Oktia Nahda; M. Saugi Abduh; Titiek Sumarawati
Jurnal Ilmiah Penelitian Mahasiswa Vol 2, No 1 (2023): Maret 2023
Publisher : Jurnal Ilmiah Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (142.448 KB)

Abstract

Penyakit jantung koroner adalah suatu penyakit pembuluh darah yang dapat menimbulkan kematian. Faktor risiko penyakit jantung koroner dapat dihitung menggunakan atherosclerotic cardiovascular disease score (ASCVD score) dan menilai stenosis dengan Gensini Score. Tujuan penelitian ini mengetahui hubungan ASCVD Score dengan derajat stenosis berdasarkan Gensini score pada pasien penyakit jantung koroner. Desain penelitian ini adalah penelitian observasional analitik dengan rancangan studi cross sectional dengan menggunakan data sekunder Rumah Sakit Islam Sultan Agung periode Januari 2020 - Desember 2021. Data dianalisis menggunakan uji Spearman dan analisis multivariat regresi logistik untuk mengetahui faktor risiko yang dominan. Data diolah menggunakan uji Spearman ditemukan nilai p sebesar 0,000 (p
The Influence of Blue Butterfly Pea Flower (Clitoria Ternatea) Gel Extract on Interleukin-10 (IL-10) and Glutathione Peroxidase (GPx) Levels Siti Asichah; Titiek Sumarawati; Setyo Trisnadi
Window of Health : Jurnal Kesehatan Vol 7 No 3 (July 2024)
Publisher : Fakultas Kesehatan Masyarakat Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/woh.v7i2.1418

Abstract

Long-term exposure to Ultraviolet B (UV-B) radiation causes increased skin darkening owing to a reaction to oxidative stress leading to elevated levels of nitric oxide (NO) and reactive oxygen species (ROS). Excessive ROS induces signal transduction and stimulates the transcription factor NF-kβ, an inflammatory mediator. Butterfly flower extract has high antioxidant levels, inhibiting ROS production and reducing inflammatory conditions, hindering MMP, preventing fibroblast cell apoptosis, and inhibiting collagen degradation. However, the role of butterfly pea flowers on IL-10 and GPx gene levels in melasma skin due to UV-B exposure is unclear. This research aims to assess the effectiveness of applying Blue Butterfly Pea Flower Extract Gel on the level of the IL-10 and GPx genes in Wistar rat strains exposed to UV-B. The UV-B-experimental research with the post-test control group. Groups K2, K3, and K4 were each exposed to UV-B at 302 nm with a MED of 160 mJ/cm2, while group K1 was the healthy group. K3 was given 5% butterfly pea flower gel, K4 was given 10% gel daily for 14 days, and K2 received base gel. On the 21st day, ELISA examined the tissue for IL-10 and GPx levels. The IL-10 gene level in the treatment group increased with higher dosages (K3=83.27±3.11, K4=90.66±4.00) compared to controls (K2=33.26±2.98, K1=104.7±3.26). The relative level of the GPx gene in the treatment group increased along with increasing dose (K3=44.90±1.44, K4=54.09±1.00) compared to the control group (K2=29.54±0.85, K1=62.43±0.85). Administration of butterfly pea flower gel can increase the level of the IL-10 gene and the level of the GPx gene in the skin tissue of mouse models of UV-B light-induced hyperpigmentation.
The Effect of Hypoxic MSC Exosome on IL-10 and SOCS3 Expression Sundari, Siti Sundari; Agung Putra; Titiek Sumarawati; Eko Setiawan; Joko Wahyu Wibowo; Hadi Sarosa
Window of Health : Jurnal Kesehatan Vol 9 No 2 (April 2026)
Publisher : Fakultas Kesehatan Masyarakat Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/woh.vi.2885

Abstract

Background: Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance and persistent inflammation. Increased expression of Suppressor of Cytokine Signaling 3 (SOCS3) and decreased Interleukin-10 (IL-10) contribute to the progression of inflammation and impaired insulin signaling. Mesenchymal stem cell-derived exosomes under hypoxic conditions (EH-MSCs) have shown potential anti-inflammatory effects and may improve inflammatory responses in T2DM. Objective: This study aimed to determine the effect of hypoxic mesenchymal stem cell exosomes (EH-MSCs) on IL-10 and SOCS3 expression in Wistar rats with type 2 diabetes mellitus. Methods: This was an in vivo experimental study using a randomized post-test only control group design. Twenty-eight Wistar rats were divided into four groups (n=7 each): negative control (K1), positive control (K2), treatment with intravenous injection of EH-MSCs 250 µL (K3), and treatment with intravenous injection of EH-MSCs 500 µL (K4). IL-10 and SOCS3 expression levels were measured using qRT-PCR on day 30. Data were analyzed using One-Way ANOVA followed by Post Hoc LSD test with a significance level of p<0.05. Results: The mean IL-10 expression was highest in K3 (1.99 ± 0.39), followed by K4 (1.47 ± 0.49), K2 (1.37 ± 0.54), and K1 (1.12 ± 0.31), with a statistically significant difference among groups (p = 0.009). Meanwhile, the mean SOCS3 expression was highest in K1 (1.09 ± 0.41) and lowest in K3 (0.56 ± 0.11), with significant differences among groups (p = 0.018). These findings indicate that EH-MSC administration increased IL-10 expression and decreased SOCS3 expression, particularly at the 250 µL dose. Conclusion: Hypoxic mesenchymal stem cell-derived exosomes significantly increased IL-10 expression and decreased SOCS3 expression in T2DM model rats, with the 250 µL dose showing the most effective anti-inflammatory response. EH-MSCs have potential as a therapeutic strategy for reducing inflammation in T2DM.
Co-Authors Agung Putra Eko Setiawan Hadi Sarosa Joko Wahyu Wibowo M. Saugi Abduh Nisya Oktia Nahda Setyo Trisnadi Siti Asichah Sundari, Siti Sundari