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All Journal Journal of Pharmacy Science and Technology
Nani Wijayanti Dyah Nurrahman
Program Studi Farmasi Universitas Hang Tuah
Medicine & Pharmacology

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AKTIVITAS ANTIDIABETES DARI BERBAGAI Genus Momordica SECARA IN VIVO Mella Afita; Nani Wijayanti Dyah Nurrahman; Giftania Wardani Sudjarwo
JOURNAL OF PHARMACY SCIENCE AND TECHNOLOGY Volume 3 No. 2: Desember 2022
Publisher : Prodi Farmasi Fakultas Kedokteran Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/pst.v3i2.43

Abstract

Diabetes mellitus (DM) is a chronic disease in the form of metabolic disorders where blood glucose levels are above normal limits. The example of the plants which can reduce blood glucose is Genus Momordica, there are 3 plants from the Genus Momordica, namely Momordica charantia, Momordica cymbalaria and Momordica dioica which contains the most common compounds found, namely saponins and charantin. This study aims to examine the presence of antidiabetic activity from various Momordica genus in vivo. The content of Saponins in the Genus Momordica works by inhibiting the work of the enzyme α-glucosidase, which is an enzyme in the intestine that functions to convert carbohydrates into glucose. The second content is charantin. Charantin works by stimulating the beta cells of the pancreatic gland to produce more insulin and increase glycogen reserves in the liver. From the literature review conducted, it can be concluded that plants from the momordica Genus, namely Momordica charantia, Momordica cymbalaria, and Momordica dioica contain saponin and charantin compounds that have the potential to be antidiabetics or reduce blood glucose levels in vivo.
Potensi Conotoxin dari Conus Spesies sebagai Analgesik Izzatiana Nabila Ramadhani; Nani Wijayanti Dyah Nurrahman; Giftania Wardani Sudjarwo
JOURNAL OF PHARMACY SCIENCE AND TECHNOLOGY Volume 3 No. 2: Desember 2022
Publisher : Prodi Farmasi Fakultas Kedokteran Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/pst.v3i2.46

Abstract

Pain is an unpleasant sensory and emotional experience resulting from actual or potential tissue damage or tends to damage tissue. Analgesic is one of the therapies commonly used to relieve pain. Analgesic itself is divided into two types, namely opioids and non-opioid, where each of these drugs has effectiveness and side effects. Researchers are trying to find other alternatives that have the potential as analgesics, with high effectiveness and fewer side effects. Conotoxin is a venom derived from Conus and it has potential as an analgesic. One form of Conotoxin that has been developed is Ziconotide. Ziconotide works by activating miu receptors that block N-type calcium channels through the G protein mechanism so that the transmission of pain signals to nerve cells can be inhibited at the spinal cord level. This review article aims to evaluate the use of Ziconotide as an analgesic. The evaluation was carried out by considering the effectiveness and the emergence of side effects from 10 article related to Ziconotide based on inclusion and exclusion criteria. The results obtained from this review article are that Ziconotide has a fairly high effectiveness as an analgesic, this can be proven by the number of patients experiencing pain reduction of more than 30% at least 40% of the population in each literature, as well as side effects that can be said to be quite mild.
Co-Authors Giftania Wardani Sudjarwo Izzatiana Nabila Ramadhani Mella Afita