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All Journal Jurnal Wiyata : Penelitian Sains dan Kesehatan Journal of Pharmaceutical Care Anwar Medika Journal of Pharmacy Science and Technology
Giftania Wardani Sudjarwo
Universitas Hang Tuah Surabaya
Health Professions Medicine & Pharmacology Public Health Social Sciences Other

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Skrining Fitokimia Metabolit Sekunder Alga Cokelat (Padina australis) dari Kepulauan Poteran Madura Dyah Nurrahman, Nani Wijayanti; Sudjarwo, Giftania Wardani; Putra, Oki Nugraha
Journal of Pharmaceutical Care Anwar Medika (J-PhAM) Vol 2 No 2 (2020): Volume 2, Nomor 2, Juni 2020
Publisher : STIKES Rumah Sakit Anwar Medika

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (554.62 KB) | DOI: 10.36932/jpcam.v2i2.25

Abstract

Alga cokelat (Padina australis) merupakan tanaman laut yang sangat melimpah di perairan Indonesia terutama Pulau Madura. Alga cokelat dikenal sebagai penghasil senyawa bioaktif seperti alginate, karagenan, dan agar yang dapat dimanfaatkan dalam dunia kefarmasian. Penelitian ini bertujuan untuk melakukan skrining fitokimia metabolit sekunder yang terdapat dalam Padina australis. Bahan yang digunakan dalam penelitian ini adalah ekstrak etanol 96% Padina asutralis, HCl 2 N, NaCl, Pereaksi Mayer dan Wagner, NH4OH 28%, methanol, air, etil asetat, Pereaksi Dragendorf, asam asetat anhidrat, H2SO4, n-heksan, anisaldehid asam sulfat, HCl (p), potongan magnesium, butanol, asam asetat glacial, NaCl 10%, gelatine, kloroform, dan FeCl3. Metode penetapan metabolit sekunder dilakukan dengan reaksi warna/pengendapan dan kromatografi lapis tipis. di Fakultas Perikanan Universitas Airlangga Surabaya dan diperoleh hasil yang menyatakan bahwa alga coklat yang digunakan yaitu Padina australis. Skrinin fitokimia yang dilakukan pada sampel ekstrak etanol 96% Padina australis menunjukkan bahwa Padina australis mengandung metabolit sekunder alkaloid, flavonoid, steroid, terpenoid, tannin, saponin.
POTENSI ANTIOKSIDAN FRAKSI ETIL ASETAT KULIT BATANG BAKAU HITAM ( Rhizophora mucronata(Lamk.)) DARI PANTAI TIMUR SURABAYA Mahmiah, Mahmiah; Sudjarwo, Giftania Wardani; Andriyani, Febby
Jurnal Wiyata Penelitian Sains dan Kesehatan Vol 8, No 1 (2021)
Publisher : LP2M IIK (Lembaga Penelitian dan Pengabdian Masyarakat Institut Ilmu Kesehatan) Bhakti Wiy

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Latar belakang:  Wilayah laut Indonesia yang luas dengan garis pantai yang panjang menyimpan potensi keanekaragaman hayati yang ada disekitar laut terutama potensi hutan mangrove. Mangrove merupakan tumbuhan halofilik yang memiliki karakteristik mampu menangani perubahan salinitas garam yang tinggi dan hipoksia pada air laut. Selama ini antioksidan yang berasal dari alam digunakan dari bahan yang ada di daratan dan pemanfaatan dari laut masih kurang. Hal ini yang mendorong untuk mengembangkan penelitian terhadap salah satu tumbuhan mangrove Rhizophora mucronata yang hidup di wilayah pesisir Pantai Timur Surabaya terhadap potensinya sebagai antioksidan. Tujuan: menentukan aktivitas antioksidan fraksi etil astetat kulit batang mangrove Rhizophora mucronata. Metode: ekstraksi dengan maserasi, fraksinasi dan uji aktivitas antioksidannya dengan TLC autograph dan dengan menggunakan metode DPPH (2,2-diphenyl- 1-picrylhydrazyl). Font huruf yang digunakan adalah Times New Roman ukuran 10, tegak (Bahasa Indonesia). Hasil: aktivitas antioksidan secara kualitatif dengan TLC autografi terdapat noda berwarna kuning menandakan positif antioksidan dengan nilai IC50fraksi etil asetat kulit batang R. mucronata sebesar 577,145 ppm. Simpulan dan saran: fraksi etil asetat kulit batang mangrove Rhizophora mucronata aktif sebagai antioksidan. Penelitian dapat dilanjutkan pada tahapan isolasi dan identifikasi senyawa aktif yang berpotensi sebagai antioksidan.
KANDUNGAN TOTAL FLAVONOID EKSTRAK AKAR MANGROVE DENGAN METODE SPEKTROFOTOMETRI UV-VIS Jannatus Mega Blezensky; Mahmiah Mahmiah; Giftania Wardani Sudjarwo
Journal of Pharmaceutical Care Anwar Medika (J-PhAM) Vol 4 No 2 (2022): Journal of Pharmaceutical Care Anwar Medika
Publisher : STIKES Rumah Sakit Anwar Medika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36932/jpcam.v4i2.81

Abstract

Mangrove mempunyai jenis akar yang berbeda-beda, akar mangrove mengandung senyawa flavonoid yang mempunyai manfaat sebagai antioksidan yang signifikan, sehingga penting untuk diteliti. Flavonoid memiliki kemampuan sebagai antioksidan karena mampu mendonasikan atom H dari gugus hidroksi kepada senyawa radikal bebas. Tujuan dari penelitian ini adalah untuk mengetahui kandungan total flavonoid ekstrak akar mangrove dengan metode spektrofotometri UV-Vis. Metode dari penelitian ini adalah studi literatur, yaitu dengan mengumpulkan literatur dari jurnal/artikel ilmiah dan akan dibahas dalam bentuk ulasan. Pada penelitian studi literatur ini didapatkan hasil bahwa spesies yang sering digunakan dan diteliti yaitu Rhizophora mucronata. Metode ekstraksi yang banyak digunakan yaitu metode maserasi. Pelarut yang banyak digunakan serta sering menghasilkan kandungan total flavonoid ekstrak akar mangrove yang tertinggi yaitu pelarut metanol. Pada penelitian studi literatur kandungan total flavonoid ekstrak akar mangrove dengan metode spektrofotometri UV-Vis ini, hasil menunjukkan bahwa kandungan total flavonoid beragam dan bervariasi, yaitu mulai dari rentang sebesar 0.00778 ± 0.00007 (mg RE/g) hingga 792 ± 0.28 (mg QE/g).
EFEKTIFITAS NEPHROPROTEKTOR EKSTRAK RUMPUT LAUT MERAH (Eucheuma cottonii) PADA MENCIT YANG DIINDUKSI DENGAN LOGAM BERAT TIMBAL Giftania Wardani Sudjarwo; Nuraini Farida
JOURNAL OF PHARMACY SCIENCE AND TECHNOLOGY Voume 1 Nomor 1
Publisher : Prodi Farmasi Fakultas Kedokteran Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/pst.v1i1.35

Abstract

This study aimed to determine the effect of the red seaweed extracts on levels of SGOT and SGPT serum mice exposed to lead per oral. The sample used were 50 male divided into 5 groups: negative control (mice were given daily with CMC /carboxy methyl cellulose 0.5 %) ; positive control (mice were given daily with CMC 0.5 % and lead 20 mg/kg BW orally once in a day for 10 days); and the treatment group ( mice were given the red seaweed extracts 200 mg; 400 mg; 800 mg/kg BW orally once daily for 28 days and lead 20 mg/kg BW on 7 th day, one hour after red seaweed extracts administration during 21 days. On day 14 measured levels of MDA, SGOT and SGPT. Data were analyzed by one-way ANOVA, followed by LSD test. The results showed that oral administration of lead acetate 20 mg/kg BW for 21 days resulted in a significant increase in SGOT, SGPT and MDA level. Treatment with red seaweed extracts 800 mg/kg BW significantly (P< 0.05) decreased the elevated SGPT, SGOT and MDA levels, compared to positive control. It can be concluded that the red seaweed extracts have a nephrotoprotective activity against lead acetat induced hepatotoxicity in mice
AKTIVITAS ANTIDIABETES DARI BERBAGAI Genus Momordica SECARA IN VIVO Mella Afita; Nani Wijayanti Dyah Nurrahman; Giftania Wardani Sudjarwo
JOURNAL OF PHARMACY SCIENCE AND TECHNOLOGY Volume 3 No. 2: Desember 2022
Publisher : Prodi Farmasi Fakultas Kedokteran Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/pst.v3i2.43

Abstract

Diabetes mellitus (DM) is a chronic disease in the form of metabolic disorders where blood glucose levels are above normal limits. The example of the plants which can reduce blood glucose is Genus Momordica, there are 3 plants from the Genus Momordica, namely Momordica charantia, Momordica cymbalaria and Momordica dioica which contains the most common compounds found, namely saponins and charantin. This study aims to examine the presence of antidiabetic activity from various Momordica genus in vivo. The content of Saponins in the Genus Momordica works by inhibiting the work of the enzyme α-glucosidase, which is an enzyme in the intestine that functions to convert carbohydrates into glucose. The second content is charantin. Charantin works by stimulating the beta cells of the pancreatic gland to produce more insulin and increase glycogen reserves in the liver. From the literature review conducted, it can be concluded that plants from the momordica Genus, namely Momordica charantia, Momordica cymbalaria, and Momordica dioica contain saponin and charantin compounds that have the potential to be antidiabetics or reduce blood glucose levels in vivo.
Potensi Conotoxin dari Conus Spesies sebagai Analgesik Izzatiana Nabila Ramadhani; Nani Wijayanti Dyah Nurrahman; Giftania Wardani Sudjarwo
JOURNAL OF PHARMACY SCIENCE AND TECHNOLOGY Volume 3 No. 2: Desember 2022
Publisher : Prodi Farmasi Fakultas Kedokteran Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/pst.v3i2.46

Abstract

Pain is an unpleasant sensory and emotional experience resulting from actual or potential tissue damage or tends to damage tissue. Analgesic is one of the therapies commonly used to relieve pain. Analgesic itself is divided into two types, namely opioids and non-opioid, where each of these drugs has effectiveness and side effects. Researchers are trying to find other alternatives that have the potential as analgesics, with high effectiveness and fewer side effects. Conotoxin is a venom derived from Conus and it has potential as an analgesic. One form of Conotoxin that has been developed is Ziconotide. Ziconotide works by activating miu receptors that block N-type calcium channels through the G protein mechanism so that the transmission of pain signals to nerve cells can be inhibited at the spinal cord level. This review article aims to evaluate the use of Ziconotide as an analgesic. The evaluation was carried out by considering the effectiveness and the emergence of side effects from 10 article related to Ziconotide based on inclusion and exclusion criteria. The results obtained from this review article are that Ziconotide has a fairly high effectiveness as an analgesic, this can be proven by the number of patients experiencing pain reduction of more than 30% at least 40% of the population in each literature, as well as side effects that can be said to be quite mild.
SKRINING FITOKIMIA DAN UJI POTENSI ANTIKANKER EKSTRAK METANOL KULIT BATANG (Rhizophora mucronata (Lamk.)) MENGGUNAKAN METODE BSLT (Brine Shrimp Lethality Test) Asniyah, Asniyah; Mahmiah, Mahmiah; Sudjarwo, Giftania Wardani
JOURNAL OF PHARMACY SCIENCE AND TECHNOLOGY Volume 4 No. 1: Desember 2023
Publisher : Prodi Farmasi Fakultas Kedokteran Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/pst.v4i2.101

Abstract

Cancer is one of the leading causes of death in the world. The main therapies for cancer include surgery, chemotherapy, radiotherapy. However, the use of chemotherapy drugs can cause side effects such as hair loss, bone marrow suppression, drug resistance. Based on these side effects, this study conducted research on natural ingredients as an alternative to cancer treatment. Rhizophora mucronata can be used as an anticancer, where people in coastal areas or around mangrove forests use mangroves as medicinal plants, and are believed to have minimal side effects so that they can be developed as traditional medicines. In this study, analysis of phytochemical screening and anticancer potential tests of methanol extract of Rhizophora mucronata stem bark was carried out from Pamurbaya, Surabaya, East Java. In this study, the BSLT (Brine Shrimp Lethality Test) method was used to test the anticancer potential with the LC50 (Letal Concentration) value as a parameter. The results of phytochemical screening of the methanol extract of Rhizophora mucronata stem bark contain tannins, saponins, alkaloids, steroids, flavonoids, anthraquinones and polyphenols and have anticancer potential with an LC50 value of 120.8656 ppm which falls into the toxic category.
Co-Authors Andriyani, Febby Asniyah, Asniyah Dyah Nurrahman, Nani Wijayanti Izzatiana Nabila Ramadhani Jannatus Mega Blezensky Mahmiah Mahmiah Mahmiah Mella Afita Nani Wijayanti Dyah Nurrahman Nuraini Farida Putra, Oki Nugraha