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All Journal Jurnal Kesehatan Islam : Islamic Health Journal Jurnal Rumpun Ilmu Kesehatan The International Science of Health Journal
Intan Nurkholidah
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Environmental Science Health Professions Medicine & Pharmacology Nursing Public Health

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HUBUNGAN KUANTITATIF STRUKTUR DAN AKTIVITAS SENYAWA TURUNAN BENZIMIDAZOL TERTAUTKAN 1,2,3-TRIAZOL SEBAGAI INHIBITOR ENZIM α-GLUKOSIDASE Intan Nurkholidah; Anita Puspa Widiyana; Yoni Rina Bintari
Jurnal Kesehatan Islam : Islamic Health Journal Vol. 12 No. 1 (2023): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v12i1.19847

Abstract

ABSTRAK Penemuan obat diabetes mellitus sedang banyak dilakukan akibat meningkatnya angka penderita diabetes mellitus. Peneliti menemukan penghambatan terhadap enzim α-glukosidase berperan penting dalam mencegah diabetes komplikasi dan mengontrol gula darah. Senyawa yang berpotensi menjadi inhibitor enzim α-glukosidase yaitu turunan benzimidazol tertautkan 1,2,3-triazol. Hubungan Kuantitatif Struktur-Aktivitas (HKSA) menjadi metode yang digunakan untuk mengetahui hubungan parameter hidrofobik (LogP dan LogS), elektronik (Etotal dan EHOMO), dan sterik (MW dan Vw) dari senyawa turunan benzimidazol tertautkan 1,2,3-triazol dengan aktivitas sebagai inhibitor enzim α-glukosidase. Parameter HKSA dan kriteria lipinski ditentukan menggunakan website online ADMET Lab 2.0 (https://admetmesh.scbdd.com/). Kriteria lipinski menunjukkan seluruh senyawa memenuhi syarat aturan sehingga senyawa turunan benzimidazol tertautkan 1,2,3-triazol dapat menjadi obat aktif jika diberikan per oral. Persamaan HKSA terbaik ditentukan dengan mempertimbangkan nilai r, nilai r2, nilai p, nilai F, dan nilai S, sehingga persamaan yang paling terbaik yaitu -LogIC50 = -0.308 LogP -0.009 Etotal +0.196, dengan n= 15, r = 0.887; r2 = 0.787; F = 12.954; p = 0.004; S = 0.103. Persamaan menunjukkan adanya hubungan parameter Log P dan Etotal dengan aktivitasnya, semakin kecil Log P dan Etotal maka semakin besar aktivitas senyawa turunan benzimidazol tertautkan 1,2,3-triazol sebagai inhibitor enzim α-glukosidase. Kata Kunci: Benzimidazol; Triazol; HKSA; Enzim α-glukosidase
Skrining Fitokimia dan Optimasi Aktivitas Anti-Ultraviolet Emulsi Ekstrak Etanol Suruhan (Peperomia pellucida) Secara In Vitro Sabrina Faradiba Ashibna; Intan Nurkholidah
Jurnal Rumpun Ilmu Kesehatan Vol. 3 No. 3 (2023): November: Jurnal Rumpun Ilmu Kesehatan
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jrik.v3i3.2692

Abstract

The Suruhan plant (Peperomia pelluida) has many benefits that cannot be separated from the compounds contained in the suruhan plant. Traditionally, the suruhan plant is used by the people of Kalimantan as a cold powder, so in this research a phytochemical screening was carried out and the SPF value of the suruhan extract emulsion was tested. The results showed that the extract contained flavonoids, alkaloids, phenolics and terpenoids. Testing the SPF values ​​obtained 5 formulas that had anti-ultraviolet activity in the medium and low categories with the highest SPF value of 31.48.
SPF Value On Nanoemulsion of Suruhan Extract (Peperomia pellucida) Sabrina Faradiba Ashibna; Intan Nurkholidah; Mutiara Nur Wulan Sari; Ike Widyaningrum
The International Science of Health Journal Vol. 1 No. 3 (2023): September : The International Science of Health Journal
Publisher : Sekolah Tinggi Ilmu Kesehatan Kesdam IV, Diponegoro Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59680/ishel.v1i3.653

Abstract

Suruhan plants are traditionally often used by Kalimantan people as cold powder . This plant contains secondary metabolites flavonoids, alkaloids, and phenolics that have high antioxidant activity. Suruhan extract as active ingredient chosen Because its potential as a sunscreen, this research aims for know the activity of nanoemulsion with suruhan extract as a sunscreen by resulting of SPF value . manufacturing process use low energy nanoemulsion method. With the constituent ingredient of Tween 80, Propylene glycol , VCO, Phenoxyethanol, and Aquadest. From the optimization results the highest % transmittance of the formula was 98.23% with a tween concentration of 11%. Test results of SPF value is obtained that nanoemulsion suruhan extract have a activity as a UV protection by category medium protection and high protection.
Co-Authors Anita Puspa Widiyana Ike Widyaningrum Mutiara Nur Wulan Sari Sabrina Faradiba Ashibna Yoni Rina Bintari