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All Journal Jurnal Penelitian Pertanian Terapan Magna Neurologica
Benedictus Benedictus, Benedictus
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Agriculture, Biological Sciences & Forestry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Pengaruh Pemberian Berbagai Dosis Curcuminoid pada Babi Terhadap Pertumbuhan dan Konversi Ransum M, Silalahi; Benedictus, Benedictus; Sinaga, Sauland
Jurnal Penelitian Pertanian Terapan Vol 12, No 1 (2012)
Publisher : Politeknik Negeri Lampung.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (61.217 KB) | DOI: 10.25181/jppt.v12i1.194

Abstract

Research about the effect of ration containing various dosage curcuminoid in pigs rations to growth rate and the ration conversion has been held since December 2005 until March 2006 in KPBI (Koperasi Peternak Babi Indonesia), Kecamatan Cisarua, Kabupaten Bandung. The purpose of this research is to know the Wright dosage of gives curcuminoid as feed additive also effect of curcuminoid as feed additive ration to growth rate and the ration conversion. This research was using 20 starter period pigs, age 2 months with weight rate 18 kg and variation coefficient 6.33%. The method was which used in this research is Complete Randomized Design with four level dosage of curcuminoid i.e, 0, 4, 8 and 12 mg/kg/body weight with five replications. The result of the research shows that giving curcuminoid as feed additive does not give the different effect to the ration conversion, but to growth rate by gives dosage of curcuminoid which 4 mg/kg/body weight effect to increase pigs growth rate. Curcuminoid which gives 4 mg/kg/body weight has give the best effect to growth rate and the ration conversion. KeyWords : Pigs, Feed Additive, Curcuminoid, Ration Conversion, Growth ate
Attenuation of Neuronal Tissue Damage in Ischemic Stroke by Tat-NR2Bct-CTM and Tat-NR2B9c Benedictus, Benedictus; Tan, Kenneth; Pratama, Vincent Kurniawan Putra; Sulastyo, Jonathan Daniel
Magna Neurologica Vol. 1 No. 2 (2023): July
Publisher : Department of Neurology Faculty of Medicine Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/magnaneurologica.v1i2.647

Abstract

Background: Worldwide, stroke accounts for 15 million cases annually. Despite improved understanding of its pathophysiology, an effective treatment is yet to be available. Objective: This review aims to expound ischemic stroke pathophysiology from a bio-molecular perspective, and present two peptides, namely Tat-NR2B9c and Tat-NR2Bct-CTM, which has been proven to attenuate neuronal tissue damage in ischemic stroke. Methods: Scoping review of several electronic databases: PubMed, Medline, Researchgate, NCBI, SpringerLink, and Google scholar. Search query included: ischemic stroke, NR2B, DAPK1, nNOS, NOX, Tat-NR2Bct-CTM and Tat-NR2B9c. Results:  It is recognizable in a sense, that the pathophysiology pivots on the NR2B-DAPK1 and PSD-95-NR2B interactions. Tat-NR2Bct-CTM and Tat-NR2B9c thwarts NR2B-DAPK1 and PSD-95-NR2B interactions, respectively. These peptides show significant reliability, with the former capable of reducing free DAPK1 by 92,85%, and the latter, the first stroke treatment in two decades to reach Phase 3 clinical trials. Conclusion: These results strongly support Tat-NR2Bct-CTM and Tat-NR2B9c as effective means to reduce neuronal tissue damage in ischemic stroke.
Co-Authors Pratama, Vincent Kurniawan Putra Sauland Sinaga Silalahi M, Silalahi Sulastyo, Jonathan Daniel Tan, Kenneth