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All Journal JBTI : Jurnal Bisnis : Teori dan Implementasi MNJ (Malang Neurology Journal) Solo Journal of Anesthesi, Pain and Critical Care
Tan, Kenneth
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Chemical Engineering, Chemistry & Bioengineering Economics, Econometrics & Finance Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health

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COMPARISON OF EFFICACY BETWEEN EDARAVONE AND RILUZOLE COMBINATION THERAPY FOR PATIENT WITH AMYOTROPHIC LATERAL SCLEROSIS: A SYSTEMATIC REVIEW AND META-ANALYSIS Budianto, Pepi; Mirawati, Diah Kurnia; B, Benedictus; Tan, Kenneth; Hafizhan, Muhammad; Putra, Stefanus Erdana
MNJ (Malang Neurology Journal) Vol. 11 No. 1 (2025): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2025.011.01.13

Abstract

Background: Amyotrophic Lateral Sclerosis (ALS) is a fatal neuromuscular disease with a survival period of less than 5 years. Although the past decade has shown a major growth of interest in Edaravone research due to its superior efficacy, a growing number of research done on Riluzole combinations for ALS therapy. Objective: A systematic review is needed to compare the patient outcomes as shown in the ALS functional rating scale (ALSFRS-R) of Edaravone and Riluzole combinations. Methods: This research is a systematic review from PubMed, ProQuest, and Science Direct. The studies included were randomized controlled trials (RCT) and post-hoc analysis of RCT published from 2012 to 2023. This research included 16 studies (11 RCT studies and 5 post-hoc studies of RCT). The studies discussed the patient population, side effects, and ALSFRS-R scores. Results: Edaravone showed better efficacy than Riluzole combination in maintaining ALSFRS-R score with mean difference between Edaravone (MD=2.19, 95% CI: 0.42-3.96, p=0.02) and Riluzole (MD=1.67, 95% CI: -0.19-3.52, p=0.08). The meta-analysis showed heterogeneity in both Edaravone (I2=90%, p<0.00001) and Riluzole (I2=77%, p=0.004) studies. Conclusion: The results conclusively showed that Edaravone was more efficacious than the explored Riluzole combinations so far. Nevertheless, Riluzole-Masitinib showed promising results to be further explored.
The Complexities of Green Purchase Behavior: An Investigation into Consumer Choices Cuandra, Fendy; Tan, Kenneth; Putra, Edy Yulianto; Lady; Susanto, Stefhani
JBTI : Jurnal Bisnis : Teori dan Implementasi Vol. 17 No. 1 (2026): April 2026
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jbti.v17i1.27491

Abstract

This study explores key techniques to encourage green purchasing behavior in Batam's food industry, which contributes significantly to pollution and resource utilization. It examines the influence of Green Purchase Attitude (GPA), Green Self-Efficacy (GSE), Subjective Norms (SN), and Environmental Knowledge (EK) on Green Purchase Intention (GPI) and Green Purchase Behavior (GPB). The results show that GPA does not significantly affect GPB; SN does not significantly affect GPI or GPB, either directly or indirectly; and EK does not significantly affect GPB. The study addresses a gap by centering on Batam consumers and contributes a novel approach by applying the Theory of Reasoned Action as the grand theory. It also recognizes GPI as a mediating variable in understanding green purchasing behavior. This study contributes to the body of knowledge by showing that GPA, SN, and EK don't directly lead people to make green purchases. Instead, results suggest that GPI and GSE significantly affect green purchase behavior. By examining both direct and indirect effects, the study improves our understanding of how psychological factors influence green purchasing. This helps build better theories for predicting how people will act sustainably and guides future research.
Comparison Between Norepinephrine-Epinephrine and Norepinephrine-Vasopressin Effectiveness in Reducing Mortality in Septic Shock: A Systematic Review Tan, Kenneth; Benedictus, Benedictus; Purnomo, Christopher William
Solo Journal of Anesthesi, Pain and Critical Care (SOJA) Vol 3, No 1 (2023): April 2023
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/soja.v3i1.62121

Abstract

 Background: Sepsis is a state of organ dysfunction caused by the immune system’s abnormal response to an infection. Septic shock is sepsis complicated by circulatory and metabolic abnormalities, oftentimes resulting in death. Prompt identification and treatment of septic shock is crucial for the survival of patients. The latest international guideline recommends the administration of norepinephrine as the first line vasopressor, with the addition of epinephrine or vasopressin as an aid in achieving the target MAP (Mean Arterial Pressure).Methods: This study is a systematic review of literatures from the databases Pubmed PMC, Science Direct, and Proquest. Systematic reviews on septic shock, norepinephrine, and epinephrine or vasopressin were among the inclusion criterias. This resulted in a total of five systematic reviews to be included in the qualitative synthesis.Results: The five included studies were not in sync as to which vasopressor is best used for the treatment of septic shock patients. One of which did not compare the two combinations within the same category, two of which favored the use of norepinephrine-epinephrine, and the other two favored the use of norepinephrine-vasopressin for the treatment of septic shock patients.Conclusion: The existing evidence were insufficient to give a conclusion of the best combination of vasopressors for septic shock patients. More research, specifically randomized controlled trials, needs to be conducted on this topic with well defined administration of combinations of vasopressors as an advancement of this systematic review. The writers also recommend the delay of anymore systematic reviews until the former recommendation has been met.
Co-Authors B, Benedictus Benedictus Benedictus, Benedictus Budianto, Pepi Cuandra, Fendy Diah Kurnia Mirawati Hafizhan, Muhammad Lady Purnomo, Christopher William Putra, Edy Yulianto Stefanus Erdana Putra Susanto, Stefhani