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All Journal Science and Technology Indonesia Buletin Ilmiah Nagari Membangun
DINI HANIFA, DINI
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Amine-Functionalized Mesoporous Silica SBA-15 for Enhanced Solubility and Release Rate of Gliclazide Sayyidina, Fasqina; Gumala, Azhoma; Zaini, Erizal; Hanifa, Dini; Hasanah, Uswatul
Science and Technology Indonesia Vol. 10 No. 3 (2025): July
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.3.963-971

Abstract

Gliclazide (GLI), a sulfonylurea-class antidiabetic drug, exhibits poor aqueous solubility, limiting its bioavailability. This study aimed to enhance gliclazide’s solubility and dissolution rate by adsorbing it into mesoporous silica SBA-15 and amine-functionalized SBA-15 (SBA-15-A). SBA-15 was synthesized using Pluronic® P123 as a template and tetraethyl orthosilicate (TEOS) as the silica precursor, while 3-aminopropyltriethoxysilane (APTES) was used to introduce amine functional groups. Gliclazide was loaded into SBA-15 and SBA-15-A at a 1:3 mass ratio. The materials (GLI, SBA-15, SBA-15-A, GLI-SBA, and GLI-SBA-A) were characterized using nitrogen adsorption-desorption isotherms, differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and powder X-ray diffraction (PXRD). Characterization revealed that the pore diameters of SBA-15 and SBA-15-A were 6.079 nm and 5.483 nm, respectively. FT-IR confirmed the interaction between gliclazide and the mesoporous carriers. SEM and TEM analysis showed crystalline gliclazide and rod-shaped morphologies for the mesopores samples. DSC and PXRD results indicated that most of the gliclazide had been converted to an amorphous form. Solubility testing over 24 hours showed that GLI-SBA and GLI-SBA-A improved gliclazide solubility by 1.375- and 2.334-fold, respectively, compared to pure gliclazide. Dissolution testing in distilled water revealed a 6.033-fold and 3.887-fold increase in the release rate at 5 minutes for GLI-SBA and GLI-SBA-A, respectively. Both solubility and release rate improvements were statistically significant (p <0.05). These findings suggest that amine functionalization of SBA-15 effectively enhances the solubility and dissolution rate of gliclazide.
Peningkatan Pengetahuan dan Status Kesehatan Masyarakat melalui Edukasi Penggunaan Obat dan Pemeriksaan Kesehatan di Kota Padang Panjang: Health Screening and Medication-Use Education to Improve Community Health Awareness in Padang Panjang Permatasari, Dita; Hanifa, Dini; Juwita, Dian Ayu; Syofyan; Angelica, Sundari Anisa; Pratiwi, Rasika Indri; Putri, Wiwing Nadia
BULETIN ILMIAH NAGARI MEMBANGUN Vol. 8 No. 4 (2025)
Publisher : LPPM (Institute for Research and Community Services) Universitas Andalas Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/bina.v8i4.834

Abstract

Low public awareness of routine health monitoring and knowledge of proper medication use remains a significant problem, leading to increased adverse drug reactions and a decline in health status. Furthermore, a lack of health literacy and high self-medication practices also increase the risk of inappropriate medication use. To address this need, this activity combines health screening and medication education as an integrative approach to improving public health awareness and drug literacy. This study used a quasi-experimental one-group pre-posttest design and was conducted on 24 October 2025, at SDN 07 Ganting, East Padang Panjang, involving 34 participants. Activities included blood pressure, glucose, cholesterol, and uric acid screenings; medical consultations; and medication education and counseling. The majority of participants were women (80%), with a dominant age range of 41–59 years (50%). Mean blood pressure was 129.1 ± 25.0/86.26 ± 13.60 mmHg, glucose 132.41 ± 74.5 mg/dL, cholesterol 214.7 ± 33.8 mg/dL, and uric acid 5.6 ± 1.8 mg/dL, indicating the presence of risk factors requiring monitoring. Knowledge levels were in the good category at both pre-test (90%) and post-test (93.3%), with no significant difference (p = 0.541). This activity contributed to strengthening drug literacy through direct education linked to screening findings, enabling participants to understand their personal health risks. This integrated screening-education approach shows potential as a more effective community intervention model in increasing public knowledge and awareness of health and the safe use of drugs.
Co-Authors Angelica, Sundari Anisa Dian Ayu Juwita Dita Permatasari Erizal Zaini Gumala, Azhoma Pratiwi, Rasika Indri Putri, Wiwing Nadia Sayyidina, Fasqina Syofyan Uswatul Hasanah, Uswatul