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All Journal Science and Technology Indonesia Martabe : Jurnal Pengabdian Kepada Masyarakat Jurnal Hilirisasi IPTEKS (JHI) Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Pharmaceutical And Biomedical Sciences Journal (PBSJ)
Azhoma Gumala
Fakultas Farmasi, Universitas Andalas
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Dentistry Education Engineering Environmental Science Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health Social Sciences Veterinary Other

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Perbandingan Mutu dan Profil Disolusi Tablet Griseofulvin Merek Dagang Generik Azhoma Gumala; Henny Lucida; Salman Salman
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 4, No 2 (2022)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v4i2.29982

Abstract

Abstract: Griseofulvin is an active pharmaceutical ingredient in Biopharmaceutic Classification Systems Class II and the price of the dosage form from commercial brands four times higher than the generic.  A comparative study on physical properties and dissolution profiles between generic and commercial brands of griseofulvin tablets has been conducted to assess whether there is difference between their qualities. The pharmaceutical properties were assessed based on the Indonesian and the United State Pharmacopeias. Results showed that the tablets fulfilled the requirements for size uniformity, weight uniformity (0.5995± 0.0075) gram - (0.6989±0.0080) gram, friability 0.08-1.10 %, hardness (10±0.7746) - (19.6±0.9165) kg/cm2, disintegration time 07.12 - 17.17 minutes with drug content of 94.20 - 99.67%. The commercial brand griseofulvin tablets A1& A2 and generic B1 met the official specification for physical characteristics. Results of dissolution test for commercial brand A1 & A2 and generic B1 showed that griseofulvin had T60min (Q ≤ 70%) and the dissolution test profiles did not follow neither first order, Higuchi, Korsmeyer Peppas, nor Langenbucher kinetic models (r < 0,95). The dissolution test for griseofulvin tablet A1 met the USP specification, T90min (Q ≥ 75%) with the release mechanism follow Langenbucher kinetic model. Abstrak: Griseofulvin merupakan zat aktif golongan Sistem Klasifikasi Biofarmasetik kelas II dengan perbedaan harga antara tablet merek dagang lebih mahal hingga empat kalinya dibandingkan tablet generik. Uji disolusi terbanding dilakukan untuk melihat adakah perbedaan mutu yang signifikan antar tablet tersebut. Metode evaluasi mutu dilakukan sesuai dengan ketentuan Farmakope Indonesia dan USP. Hasil evaluasi mutu fisik tablet meliputi keseragaman ukuran, keseragaman bobot yaitu (0,5995± 0,0075) – (0,6989±0,0080) gram, kerapuhan 0,08 - 1,10%, kekerasan (10±0,7746) - (19,6±0,9165) kg/cm2, & waktu hancur  07.12 - 17.17 menit dan penetapan kadar  94,20 - 99,67%, memenuhi ketentuan Farmakope Indonesia. Profil disolusi tidak mengikuti model kinetika orde satu, Higuchi, Korsmeyer Peppas, ataupun Langenbucher (r < 0,95). Hasil uji disolusi tablet A1 yang dilakukan berdasarkan  USP memenuhi persyaratan T90 min  (Q ≥ 75%) dan memiliki profil disolusi mengikuti  persamaan Langenbucher (r>0,95). Keywords: Profil disolusi, tablet griseofulvin, mutu tablet, model matematika
Identifikasi dan Edukasi Adverse Drug Reactions dan Drug Related Problems pada Masyarakat Lanjut Usia di Posyandu Lansia Lubuk Begalung Padang Azhoma Gumala; Yoneta Srangenge; Henny Lucida
Warta Pengabdian Andalas Vol 30 No 2 (2023)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jwa.30.2.346-353.2023

Abstract

Geriatric tend to suffer from more than one disease and consume more than one drug yearly. This study aimed to identify and educate geriatrics in the elderly community in Lubuk Begalung Padang, West Sumatra, about adverse drug reactions and drug-related problems. This society activity was carried out by direct interviews using a questionnaire and counselling individual patients. The results of this activity were presented descriptively. A total of 30 female (93.1%) and male (2.60%) subjects were involved in this study. Data showed that 86.70% of the subjects did not carry out regular medical check-ups, 63.4% of the subjects used three or more types of drugs, 77% of the subjects did not know the names of the drugs given, and 56.70% did not know nor did not receive information of the usage of the drug. In conclusion, the people in Lubuk Begalung sub-district Padang still lack knowledge regarding drugs and the risk of polypharmacy, so drug education and counselling for the community needs to be improved. In this activity, the effect of providing education on changes in the knowledge or behaviour of the respondents was not measured. However, the respondents expressed their satisfaction with this activity and hoped that the activities would continue in the future
Amine-Functionalized Mesoporous Silica SBA-15 for Enhanced Solubility and Release Rate of Gliclazide Sayyidina, Fasqina; Gumala, Azhoma; Zaini, Erizal; Hanifa, Dini; Hasanah, Uswatul
Science and Technology Indonesia Vol. 10 No. 3 (2025): July
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.3.963-971

Abstract

Gliclazide (GLI), a sulfonylurea-class antidiabetic drug, exhibits poor aqueous solubility, limiting its bioavailability. This study aimed to enhance gliclazide’s solubility and dissolution rate by adsorbing it into mesoporous silica SBA-15 and amine-functionalized SBA-15 (SBA-15-A). SBA-15 was synthesized using Pluronic® P123 as a template and tetraethyl orthosilicate (TEOS) as the silica precursor, while 3-aminopropyltriethoxysilane (APTES) was used to introduce amine functional groups. Gliclazide was loaded into SBA-15 and SBA-15-A at a 1:3 mass ratio. The materials (GLI, SBA-15, SBA-15-A, GLI-SBA, and GLI-SBA-A) were characterized using nitrogen adsorption-desorption isotherms, differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and powder X-ray diffraction (PXRD). Characterization revealed that the pore diameters of SBA-15 and SBA-15-A were 6.079 nm and 5.483 nm, respectively. FT-IR confirmed the interaction between gliclazide and the mesoporous carriers. SEM and TEM analysis showed crystalline gliclazide and rod-shaped morphologies for the mesopores samples. DSC and PXRD results indicated that most of the gliclazide had been converted to an amorphous form. Solubility testing over 24 hours showed that GLI-SBA and GLI-SBA-A improved gliclazide solubility by 1.375- and 2.334-fold, respectively, compared to pure gliclazide. Dissolution testing in distilled water revealed a 6.033-fold and 3.887-fold increase in the release rate at 5 minutes for GLI-SBA and GLI-SBA-A, respectively. Both solubility and release rate improvements were statistically significant (p <0.05). These findings suggest that amine functionalization of SBA-15 effectively enhances the solubility and dissolution rate of gliclazide.
Utilization of Unprocessed Sugarcane Bagasse and Coffee Waste into Soap Products Rachmaini, Fitri; Abdillah, Rahmad; Gumala, Azhoma; Srangenge, Yoneta
Warta Pengabdian Andalas Vol 32 No 4 (2025)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jwa.32.04.473-479.2025

Abstract

The increasing by-products from sugarcane and coffee consumption have resulted in a greater volume of sugarcane bagasse and coffee waste with potential environmental impacts. Physically and chemically, coffee and sugarcane waste can be processed into soap products without further processing. This community service activity aimed to provide education and practical skills in utilising coffee and sugarcane waste as raw materials for hand soap production. The activity was conducted at the Baitussalam Mosque in Gadut, Padang City, with 20 participants. The implementation methods included material presentation, demonstrations, and hands-on practice in liquid soap formulation. The soap formula used sugarcane and coffee waste as the main ingredients with additional components including Texapon as a surfactant, EDTA as a chelating agent, salt as a viscosity regulator, warm water, and fragrance. The findings indicated that participants comprehended the potential of utilising sugarcane and coffee waste, allowing them to produce a basic liquid soap product for daily usage. Soap made from sugarcane and coffee waste has the potential to become an organic product with antioxidant and antimicrobial benefits for the skin. This activity aims to increase public awareness of the importance of waste management and promote the development of environmentally friendly, nature-based creative enterprises.
OPTIMALISASI FARMAKOTERAPI: IDENTIFIKASI DAN EDUKASI TENTANG ADRs DAN DRPs PADA PESERTA PROLANIS WILAYAH PUSKESMAS SURIAN, KABUPATEN SOLOK, SUMATERA BARAT Gumala, Azhoma; Armenia, Armenia; Prima Putra, Deddi; Syafni, Nova; Handayani, Fitri; Eka Putri, Desi; Furqan, Mainal; Sentat, Triswanto; Gusnelti, Yessi; Lucida, Henny
Martabe : Jurnal Pengabdian Kepada Masyarakat Vol 9, No 1 (2026): MARTABE : JURNAL PENGABDIAN KEPADA MASYARAKAT
Publisher : Universitas Muhammadiyah Tapanuli Selatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31604/jpm.v9i1.%p

Abstract

Peningkatan risiko reaksi obat yang tidak diinginkan (adverse drug reactions/ADRs) dan masalah terkait obat (drug-related problems/DRPs) pada pasien penyakit kronis, khususnya peserta Program Pengelolaan Penyakit Kronis (PROLANIS), sangat membutuhkan informasi dan edukasi intensif terkait optimalisasi terapi. Kegiatan pengabdian ini bertujuan untuk mengidentifikasi insiden ADRs dan DRPs pada kelompok PROLANIS di Puskesmas Surian dan memberikan edukasi yang terfokus untuk meminimalkan risiko, demi mencapai terapi optimal. Kegiatan diawali dengan wawancara dan pengumpulan data kuesioner dari 30 responden (semua perempuan). Hasil demografi menunjukkan mayoritas responden (70,00%) berusia 45–64 tahun, dan dua pertiga (66,67%) mengalami polifarmasi (menderita 3–7 penyakit kronis). Empat penyakit utama yang diderita adalah artritis, hipertensi, hiperurisemia, dan dislipidemia. Penting untuk dicatat, 60% responden melaporkan keluhan yang mengindikasikan ADRs dan DRPs. Sebagian besar subjek memperoleh obat dari tenaga kesehatan formal (86,67%). Tindak lanjut kegiatan mencakup pemeriksaan kesehatan gratis (tekanan darah, gula darah, kolesterol, dan asam urat) serta konseling langsung. Pasien PROLANIS menerima edukasi mendalam tentang cara penggunaan obat yang benar, terutama dalam terapi polifarmasi, untuk meminimalkan masalah terkait obat. Disimpulkan bahwa edukasi intensif dan berkelanjutan mengenai obat-obatan, pengobatan alternatif, dan suplemen kesehatan kepada komunitas PROLANIS sangat penting. Intervensi ini secara signifikan berkontribusi pada keselamatan pasien dan meningkatkan pemahaman masyarakat dalam pengelolaan penyakit kronis.
PENINGKATAN EFISIENSI DAN PERLUASAN PASAR NIRANTA GULA AREN KOTA PADANG MELALUI DIGITALISASI PEMASARAN DAN KEUANGAN Komalasari, Sanda Patrisia; Tri, Diwah Ganda; Hadelina, Rizka; Mardiah, Ainul; Irwan, Naufal Rafif; Fadhilah, Rifa; Gumala, Azhoma; Fauzana, Annisa; Rahman, Khalilul
Jurnal Hilirisasi IPTEKS Vol. 8 No. 3 (2025)
Publisher : LPPM Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jhi.v8i3.906

Abstract

Micro, Small, and Medium Enterprises (MSMEs), specifically Niranta Palm Sugar in Padang City, hold immense potential but face significant challenges due to manual financial management and conventional marketing strategies. These limitations hinder operational efficiency and market expansion. This community service project aimed to enhance the efficiency and market reach of Niranta by adopting digital tools for marketing and finance. A qualitative approach with an intensive mentorship method was implemented, starting with a needs analysis, followed by financial management training using the SIAPIK application, and the development of digital marketing infrastructure, including a website, a Shopee account, and an Instagram profile. The program yielded measurable positive impacts. In finance, although the operational implementation was delegated, the partner successfully adopted a more structured digital recording system, demonstrating increased awareness of the importance of good financial governance. In marketing, the new digital infrastructure effectively broadened the market reach. The company’s website recorded 607 visitors in the first month, and the Shopee account successfully gained followers and initiated sales transactions. While a significant increase in sales is not yet apparent as the program is in its early stages, it has successfully opened new markets. Overall, the digitalization of marketing and finance has proven effective in substantially boosting the competitiveness of Niranta Palm Sugar MSME, demonstrating that technology-focused mentorship can have a tangible impact on the growth of MSME businesses.
Optimasi Teknik Pengawetan dan Pendampingan GMP untuk Memperpanjang Masa Simpan Produk Gula Aren Niranta Gumala, Azhoma; Fauzana, Annisa; Komalasari, Sanda Patrisia; Tri, Diwah Ganda; Hadelina, Rizka; Mardiah, Ainul; Irwan, Naufal Rafif; Fadhilah, Rifa; Rahman, Khalilul
Jurnal Hilirisasi IPTEKS Vol. 8 No. 4 (2025)
Publisher : LPPM Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jhi.v8i4.912

Abstract

Niranta is a micro palm sugar processing business in Padang with export potential and high-quality products. However, the business faces challenges with limited shelf life, especially for liquid palm sugar which deteriorates within less than 6 months after opening due to microbial growth and physicochemical changes. This Community Service Program was designed to extend the shelf life of both powdered and liquid palm sugar products through scientific formulation optimization, improved preservation techniques, discussion about appropriate packaging solutions, and adherence to Good Manufacturing Practices. The 8-month program consisted of socialization sessions, hands-on training, technology transfer, and continuous mentoring focused on preservation methods, hygiene standards, and GMP implementation. Key interventions included the addition of sodium benzoate as a preservative in liquid palm sugar, process control using sterilization for packaging, and Good Manufacturing Practices mentoring collaboration with National Agency of Food and Drug Administration (BPOM) Padang. Real-time shelf-life testing was conducted on treated products for over 6 months post-opening. Preliminary results demonstrate significant improvement: liquid palm sugar supplemented with 0.1 % sodium benzoate remained microbiologically and organoleptically stable beyond 6 months. These findings confirm the effectiveness of combined preservation and process control strategies. To ensure long-term sustainability, recommendations include formal collaboration with the National Agency of Drug and Food Control (BPOM) for GMP certification, advanced training for workers, and ongoing accelerated and real-time stability studies.
Co-Authors Ainul Mardiah Armenia, Armenia DINI HANIFA, DINI Eka Putri, Desi Erizal Zaini Fadhilah, Rifa Fauzana, Annisa Fitri Handayani Furqan, Mainal Gusnelti, Yessi Hadelina, Rizka Henny Lucida Irwan, Naufal Rafif Mega Fatimah Rosana Nova Syafni Prima Putra, Deddi Rachmaini, Fitri Rahman, Khalilul Salman Salman Sanda Patrisia Komalasari Sayyidina, Fasqina Srangenge, Yoneta Tri, Diwah Ganda Triswanto Sentat Uswatul Hasanah, Uswatul Yoneta Srangenge