Article Per Year (5 Year)
p-Index From 2020 - 2025
0.444
P-Index
This Author published in this journals
All Journal Berkala Kedokteran
Dwi Laksono Adiputro, Dwi Laksono
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
The Risk of Adverse Drug-Drug Interactions for Stable Angina Pectoris Patients with Heart Failure Complication Prescribed Polypharmacy Fadillah, Ahmad Aldi; Bakhriansyah, Mohammad; Yustikasari, Intan; Nurikhwan, Pandji Winata; Adiputro, Dwi Laksono
Berkala Kedokteran Vol 19, No 2 (2023)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v19i2.17404

Abstract

Stable angina pectoris (SAP) is an imbalance that occurs when myocardial oxygen need increases disproportionally, causing complaints of chest pain. Uncontrolled SAP can lead to a complication of heart failure (HF). Polypharmacy treatment frequently given to SAP patients with HF complications can be potentially detrimental for them. This study aims to determine the risk of adverse drug-drug interactions in SAP patients with HF complications prescribed polypharmacy. This was an analytic observational study with a cross-sectional approach using retrospective data from medical record data from 2020-2021 among hospitalized patients in cardiology ward Ulin General Hospital, Banjarmasin. Potential drug-drug interactions were determined using the Lexicomp tool from the UpToDate® site. Prevalence Odds Ratio (POR) and 95% Confidence Interval (95%CI) were determined using the Logistic Regression test at the 95% level of confidence. Twenty-four SAP patients with HF were recruited. According to its potential interactions, the most interactions were under category C (82.6%), followed by category B (11.3%) and category D (6.0%). Based on its level of severity, the most common was moderate (77.4%), followed by minor (13.0%) and major (9.5%). SAP patients with HF who were not prescribed polypharmacy had a lower risk of adverse drug-drug interactions by 64.7% compared to polypharmacy users, although it was not statistically difference (crude POR 0.353, 95% CI; 0.360-3.421; p-value = 0.369). This study shows that there is a tendency of lower risk of adverse drug-drug interactions in SAP patients with HF complication prescribed polypharmacy compared to those without polypharmacy, but the association is not statistically significant.
The Association between Coagulation Parameters, C-Reactive Protein, D-Dimer and In-Hospital Mortality of Covid-19 Patients with Suspected Pulmonary Embolism Delmi, Anwari; Adiputro, Dwi Laksono; Nurrasyidah, Ira; Yasmina, Alfi
Berkala Kedokteran Vol 20, No 1 (2024)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v20i1.18896

Abstract

COVID-19 is a respiratory disease with severe cardiovascular complications, one of them is pulmonary embolism (PE). Studies have shown many contributing factors related to mortality of hospitalized COVID-19 patients that developed pulmonary embolism. This study aimed to find the association between coagulation parameters (PT and APTT), C-reactive protein (CRP), and D-dimer with in-hospital mortality of COVID-19 patients with suspected PE. COVID-19 patients in Ulin General Hospital Banjarmasin who met the clinical criteria of suspected PE, assessed with clinical scorings (Well’s score for PE and Padua prediction score for venous thromboembolism), and receiving anticoagulant therapy recorded in medical records were included in this study. A total of 91 patients were included, with most patients were female (59.3%), average age of 53.36 years, average BMI of 25.82 kg/m2, having normal electrocardiogram (79.1%), with history of hypertension (56%), and no histories of smoking (94.5%), diabetes mellitus (70.3%), heart failure (93.4%), coronary artery disease (96.7%), and chronic lung disease (95.6%).  As much as 39.57% patients with suspected PE was deceased during the course of hospitalization. Unadjusted analysis showed significant increased levels of PT, APTT, and CRP, in deceased patients compared to those discharged alive (mean 14.62 vs 11.91 seconds, 42.94 vs 28.57 seconds, and 98.19 vs 47.01 mg/dL, respectively; p value < 0.01), and a non-significant increased level of D-dimer (mean 10.89 mg/L; p = 0.09). Multivariate logistic regression showed non-significant associations between PT, APTT, D-dimer, and CRP with in-hospital mortality (p values of 0.06, 0.14, 0.52, and 0.23, respectively). In conclusion, there is no association between coagulation parameters, CRP, and D-dimer levels with in-hospital mortality in COVID-19 patients with suspected PE.  A further study with a larger sample size is needed to see the role of laboratory findings in predicting in-hospital mortality in COVID-19 patients with suspected PE. 
Co-Authors Alfi Yasmina Delmi, Anwari Fadillah, Ahmad Aldi Ira Nurrasyidah Mohammad Bakhriansyah Pandji Winata Nurikhwan Yustikasari, Intan